Healthy fat link to bowel disease 有益健康的脂肪可能导致肠道
文章来源:未知 文章作者:meng 发布时间:2009-07-24 07:23 字体: [ ]  进入论坛

A high intake1 of polyunsaturated fat in the diet, while good for the heart, may lead to inflammatory bowel2 disease, say researchers.


Some margarines contain linoleic acid
Some margarines contain linoleic acid

Experts believe a high intake of linoleic acid(亚油酸), found in foods like "healthy" margarines(人造黄油), may be implicated3 in(牵连) a third of ulcerative colitis(溃疡性结肠炎) cases.

The researchers base their findings, due to be published in Gut4, on food diaries from more than 200,000 people.

If the link proves to be causal, some people might want to modify their diet.

The researchers also found that a diet rich in another type of fat, omega 3 fatty acid found in oily fish such as salmon5(鲑,大马哈鱼) and herring(青鱼), reduced the likelihood of developing ulcerative colitis by 77%.

Linoleic acid is a naturally occurring essential fatty acid, present in a variety of foods, including the oils of seeds and nuts, such as sunflower, safflower(红花), soya(大豆), corn seeds or walnut6(胡桃) oils.

The multinational7 team working on the EPIC8 (European Prospective9 Investigation10 into Cancer and Nutrition) study say there is a plausible11 biological mechanism12 that could explain why linoleic acid is linked with this bowel condition.

Cell membranes13

Once in the body, linoleic acid is converted to arachidonic acid(花生四烯酸), which is a component14 of the cell membranes in the bowel.

Arachidonic acid can then be converted into various inflammatory chemicals, high levels of which have been found in the bowel tissue of patients with ulcerative colitis.

In all, 126 of the people in the study developed ulcerative colitis after an average period of four years.

After adjusting for other factors likely to influence the results, including smoking, age, total energy intake, and use of aspirin15, those whose diets included the most linoleic acid were more than twice times as likely to develop the condition as those whose diets contained the least.

Lead researcher Dr Andrew Hart of the University of East Anglia, Norwich, said: "There are no dietary modifications16 of benefit in patients with ulcerative colitis, although, based on this study's findings, a diet low in linoleic acid may merit investigation."

In the UK, people consume on average about 10g per day of linoleic acid, found in around nine level teaspoons17 of polyunsaturated margarine or three teaspoons of sunflower oil.

In the study, the people who consumed the most linoleic acid had a daily intake three times this or more.

Biologically plausible

Dr Anton Emmanual, medical director of the digestive disorders18 charity Core, stressed that the study did not prove that linoleic acid caused bowel disorders, and warned that dietary diaries could be unreliable.

However, he said: "Nevertheless there is good biological plausibility19(似有道理) of why linoleic acid can cause inflamation, and certainly Western diets are often excessive in this kind of fat.

"The omega 3 fish oils counteract20 the harmful effects of lineloic acid it would be helpful to see whether diets high in fish oils reduce colitis.

"Lineloic acid may have small part to play in some patients, but factors such as smoking, bacteria and stress are likely to be at least as important."

Professor Jon Rhodes, of the British Society of Gastroenterology, said the study was interesting, but also stressed it did not prove cause and effect - further tightly controlled studies would be needed to do that.

Dr Elisabeth Weichselbaum, of the British Nutrition Foundation, said the study was interesting.

But added: "The results need to be interpreted(解释,演出) with caution.

"People who have very high intakes21 of omega-6 fats are likely to have a generally different diet from those with low intakes. Therefore, it may as well be possible that there are other factors that could have an effect."


1 intake 44cyQ     
  • Reduce your salt intake.减少盐的摄入量。
  • There was a horrified intake of breath from every child.所有的孩子都害怕地倒抽了一口凉气。
2 bowel Bszzy     
  • Irritable bowel syndrome seems to affect more women than men.女性比男性更易患肠易激综合征。
  • Have you had a bowel movement today?你今天有排便吗?
3 implicated 8443a53107b44913ed0a3f12cadfa423     
  • These groups are very strongly implicated in the violence. 这些组织与这起暴力事件有着极大的关联。 来自《简明英汉词典》
  • Having the stolen goods in his possession implicated him in the robbery. 因藏有赃物使他涉有偷盗的嫌疑。 来自《现代汉英综合大词典》
4 gut MezzP     
  • It is not always necessary to gut the fish prior to freezing.冷冻鱼之前并不总是需要先把内脏掏空。
  • My immediate gut feeling was to refuse.我本能的直接反应是拒绝。
5 salmon pClzB     
  • We saw a salmon jumping in the waterfall there.我们看见一条大马哈鱼在那边瀑布中跳跃。
  • Do you have any fresh salmon in at the moment?现在有新鲜大马哈鱼卖吗?
6 walnut wpTyQ     
  • Walnut is a local specialty here.核桃是此地的土特产。
  • The stool comes in several sizes in walnut or mahogany.凳子有几种尺寸,材质分胡桃木和红木两种。
7 multinational FnrzdL     
  • The firm was taken over by a multinational consulting firm.这家公司被一个跨国咨询公司收购。
  • He analyzed the relationship between multinational corporations and under-developed countries.他分析了跨国公司和不发达国家之间的关系。
8 epic ui5zz     
  • I gave up my epic and wrote this little tale instead.我放弃了写叙事诗,而写了这个小故事。
  • They held a banquet of epic proportions.他们举行了盛大的宴会。
9 prospective oR7xB     
  • The story should act as a warning to other prospective buyers.这篇报道应该对其他潜在的购买者起到警示作用。
  • They have all these great activities for prospective freshmen.这会举办各种各样的活动来招待未来的新人。
10 investigation MRKzq     
  • In an investigation,a new fact became known, which told against him.在调查中新发现了一件对他不利的事实。
  • He drew the conclusion by building on his own investigation.他根据自己的调查研究作出结论。
11 plausible hBCyy     
  • His story sounded plausible.他说的那番话似乎是真实的。
  • Her story sounded perfectly plausible.她的说辞听起来言之有理。
12 mechanism zCWxr     
  • The bones and muscles are parts of the mechanism of the body.骨骼和肌肉是人体的组成部件。
  • The mechanism of the machine is very complicated.这台机器的结构是非常复杂的。
13 membranes 93ec26b8b1eb155ef0aeaa845da95972     
n.(动物或植物体内的)薄膜( membrane的名词复数 );隔膜;(可起防水、防风等作用的)膜状物
  • The waste material is placed in cells with permeable membranes. 废液置于有渗透膜的槽中。 来自辞典例句
  • The sarcoplasmic reticulum is a system of intracellular membranes. 肌浆网属于细胞内膜系统。 来自辞典例句
14 component epSzv     
  • Each component is carefully checked before assembly.每个零件在装配前都经过仔细检查。
  • Blade and handle are the component parts of a knife.刀身和刀柄是一把刀的组成部分。
15 aspirin 4yszpM     
  • The aspirin seems to quiet the headache.阿司匹林似乎使头痛减轻了。
  • She went into a chemist's and bought some aspirin.她进了一家药店,买了些阿司匹林。
16 modifications aab0760046b3cea52940f1668245e65d     
n.缓和( modification的名词复数 );限制;更改;改变
  • The engine was pulled apart for modifications and then reassembled. 发动机被拆开改型,然后再组装起来。 来自《简明英汉词典》
  • The original plan had undergone fairly extensive modifications. 原计划已经作了相当大的修改。 来自《简明英汉词典》
17 teaspoons 2373c24f8a940bcba4d8d55a1e80e98c     
n.茶匙( teaspoon的名词复数 );一茶匙的量
  • Add two teaspoons of salt. 加两小匙盐。
  • Add 3 heaped teaspoons of sugar. 加满满的三匙糖。 来自《简明英汉词典》
18 disorders 6e49dcafe3638183c823d3aa5b12b010     
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调
  • Reports of anorexia and other eating disorders are on the increase. 据报告,厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
  • The announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》
19 plausibility 61dc2510cb0f5a78f45d67d5f7172f8f     
n. 似有道理, 能言善辩
  • We can add further plausibility to the above argument. 我们可以在上述论据之外,再进一步增添一个合理的论据。
  • Let us consider the charges she faces, and the legal plausibility of those charges. 让我们考虑一下她面临的指控以及这些指控在法律上的可信性。
20 counteract vzlxb     
  • The doctor gave him some medicine to counteract the effect of the poison.医生给他些药解毒。
  • Our work calls for mutual support.We shouldn't counteract each other's efforts.工作要互相支持,不要互相拆台。
21 intakes 8ef0c0b97d557507433c00f72a6fc6e2     
吸入( intake的名词复数 ); (液体等)进入口; (一定时期内)进入或纳入的人数; (采煤)进风巷道
  • The Tornado jet fighter-bomber has two air intakes. 旋风式喷气轰炸机有两个空气入口。
  • The air intakes to the carburetors were filling up with freezing snow. 汽化器的进气道被积雪封住了。 来自英汉非文学 - 百科语料821
TAG标签: disease fat healthy bowel