性激素黄体酮被用于治疗脑损伤的临床试验
文章来源:未知 文章作者:meng 发布时间:2010-02-21 06:30 字体: [ ]  进入论坛
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Natural progesterone, the sex hormone1 used in the first contraceptive pills, is to be tested on patients with severe head injuries.

天然黄体酮,首批避孕药中使用的性激素,被用于治疗有严重脑损伤病人的临床试验中。

Progesterone protects neurons in the brain after an injury
Progesterone protects neurons in the brain after an injury

Scientists will begin a phase III clinical trial in March and say the drug could save patients' lives and reduce damage to their brains.

They announced the trial at the annual meeting of the American Association for the Advancement2 of Science.

It will involve 1,000 patients in 17 trauma3(外伤 ,创伤) centres across the US.

Dr David Wright, associate professor of emergency medicine at Emory University in Atlanta, will lead the trial.

Complex condition

Previous studies have shown that progesterone(黄体酮) supports the normal development of neurons(神经原,神经细胞) in the brain, and that the hormone has a protective effect on damaged brain tissue.

Dr Wright told BBC News: "Traumatic brain injury is a complex condition - there's swelling4(膨胀) , and neuronal death and damage occurring all at the same time.

"The beauty of progesterone is that it seems to work on all of those things."

In earlier tests, the Emory University researchers found that progesterone reduced the risk of death in patients with brain injuries.

Dr Wright hopes that, following this trial, progesterone will become the first drug treatment in 30 years to be approved specifically for severe traumatic brain injury.

Yams

The active ingredient(有效成分,活性成分) , natural progesterone, is very similar to that used in the first contraceptive pills(避孕药) . This has now been superseded5(取代,废弃) by a synthetic6 progesterone known as progestin. But, for brain injury, only the natural hormone appears to have the desired protective effect.

During the trial, patients with blunt(钝的,生硬的) trauma head injuries will be given an infusion7(灌输,浸泡) of natural progesterone that will last for four days. The hormone is extracted from yams(山药,洋芋) - also known as sweet potatoes(番薯,白薯) .

"The dose is probably about three times what would be found in [the blood] of a female in the third trimester(晚期妊娠) of pregnancy," Dr Wright explained.

The US Food and Drug Administration (FDA食品及药物管理局) has made a special allowance for the team to administer the drug without patients' consent(同意,赞成) - so it can be given as soon as possible and have the maximum protective effect.



点击收听单词发音收听单词发音  

1 hormone uyky3     
n.荷尔蒙,激素,内分泌
参考例句:
  • Hormone implants are used as growth boosters.激素植入物被用作生长辅助剂。
  • This hormone interacts closely with other hormones in the body.这种荷尔蒙与体內其他荷尔蒙紧密地相互作用。
2 advancement tzgziL     
n.前进,促进,提升
参考例句:
  • His new contribution to the advancement of physiology was well appreciated.他对生理学发展的新贡献获得高度赞赏。
  • The aim of a university should be the advancement of learning.大学的目标应是促进学术。
3 trauma TJIzJ     
n.外伤,精神创伤
参考例句:
  • Counselling is helping him work through this trauma.心理辅导正帮助他面对痛苦。
  • The phobia may have its root in a childhood trauma.恐惧症可能源于童年时期的创伤。
4 swelling OUzzd     
n.肿胀
参考例句:
  • Use ice to reduce the swelling. 用冰敷消肿。
  • There is a marked swelling of the lymph nodes. 淋巴结处有明显的肿块。
5 superseded 382fa69b4a5ff1a290d502df1ee98010     
[医]被代替的,废弃的
参考例句:
  • The theory has been superseded by more recent research. 这一理论已为新近的研究所取代。
  • The use of machinery has superseded manual labour. 机器的使用已经取代了手工劳动。
6 synthetic zHtzY     
adj.合成的,人工的;综合的;n.人工制品
参考例句:
  • We felt the salesman's synthetic friendliness.我们感觉到那位销售员的虚情假意。
  • It's a synthetic diamond.这是人造钻石。
7 infusion CbAz1     
n.灌输
参考例句:
  • Old families need an infusion of new blood from time to time.古老的家族需要不时地注入新鲜血液。
  • Careful observation of the infusion site is necessary.必须仔细观察输液部位。
TAG标签: patients drug sex hormone
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