Flawed gene link to ovary cancer 基因缺陷或导致卵巢癌
文章来源:未知 文章作者:meng 发布时间:2009-08-03 02:26 字体: [ ]  进入论坛

Scientists have identified a genetic1 flaw which can increase the risk of ovarian cancer.


Over 4,000 UK women die from ovarian cancer each year
Over 4,000 UK women die from ovarian cancer each year

The international team of researchers, led by UK scientists, looked at the DNA2 of 17,000 women for their study.

In Nature Genetics, they said carrying two copies of the flaw increased the chance of cancer by 40% - around 15% of UK women have both copies.

Cancer experts said it was an important discovery which could help manage women who were at increased risk.

Ovarian(卵巢) cancer is the fifth most common cancer in women in the UK with around 6,800 new cases diagnosed each year in the UK.

This leads to around 4,300 deaths each year.

The BRCA1 and BRCA2 genes3, which cause breast cancer are already known to significantly increase the risk of ovarian cancer - but faults in these genes are rare and probably cause fewer than 5% of cases so scientists have been looking for other genetic faults which could help explain inherited(遗传的,继承权的) risk.

'Genuine hope'

The researchers, led by scientists based at the Cancer Research UK Genetic Epidemiology Unit at the University of Cambridge and University College London (UCL), searched through the genomes of 1,810 women with ovarian cancer and 2,535 women without the disease from across the UK.

They analysed 2.5m variations in the genetic code and found genetic "letters" - called single nucleotide(核苷) polymorphisms(多形性) (SNPs) - which when spelt slightly differently increase ovarian cancer risk in some women.

It is the first time scientists have found a SNP linked uniquely to risk of ovarian cancer.

Everyone has 23 pairs of chromosomes5(染色体), with one of each pair inherited from each parent.

This SNP is located on chromosome4 nine.

The risk of developing ovarian cancer for women carrying the variation on both chromosomes is 14 in 1,000, compared with 10 in 1,000 for those who do not.

Carrying one flawed variant6 increases the risk to 12 in 1,000.

Scientists confirmed their finding after working with the international Ovarian Cancer Association Consortium and examining more than 7,000 more women with ovarian cancer and 10,000 women without disease.

'Laying the groundwork'

Dr Simon Gayther from UCL, who worked on the study, said: "There is now a genuine hope that as we find more genetic variants7, we can start to identify the women at greatest risk and this could help doctors to diagnose the disease earlier when treatment has a better chance of being successful."

Dr Andrew Berchuck, head of the international Ovarian Cancer Association Consortium steering8 committee(筹划指导委员会), said: "This study confirms that ovarian cancer risk is partly determined9 by genetic variants present in a large number of women.

"This initial discovery and others that will likely follow in the future lay the groundwork for individualised early detection and prevention approaches to reduce deaths from ovarian cancer."

Dr Lesley Walker, director of cancer information at Cancer Research UK, added: "This is an important discovery.

"This research paves the way for scientists to discover even more genes linked to ovarian cancer and could lead to new approaches to treat or prevent the disease. Crucially it will help doctors manage women who are at increased risk."


1 genetic PgIxp     
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
2 DNA 4u3z1l     
(缩)deoxyribonucleic acid 脱氧核糖核酸
  • DNA is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
  • Gene mutations are alterations in the DNA code.基因突变是指DNA密码的改变。
3 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
4 chromosome 7rUzX     
  • Chromosome material with exhibits of such behaviour is called heterochromatin.表现这种现象的染色体物质叫做异染色质。
  • A segment of the chromosome may become lost,resulting in a deletion.染色体的一个片段可能会丢失,结果产生染色体的缺失。
5 chromosomes 11783d79c0016b60332bbf1856b3f77d     
n.染色体( chromosome的名词复数 )
  • Chromosomes also determine the sex of animals. 染色体也决定动物的性别。 来自《简明英汉词典》
  • Each of four chromosomes divide longitudinally. 四种染色体的每一种都沿着纵向分裂。 来自《现代汉英综合大词典》
6 variant GfuzRt     
  • We give professional suggestions according to variant tanning stages for each customer.我们针对每位顾客不同的日晒阶段,提供强度适合的晒黑建议。
  • In a variant of this approach,the tests are data- driven.这个方法的一个变种,是数据驱动的测试。
7 variants 796e0e5ff8114b13b2e23cde9d3c6904     
n.变体( variant的名词复数 );变种;变型;(词等的)变体
  • Those variants will be preserved in the'struggle for existence". 这些变异将在“生存竞争”中被保留下来。 来自辞典例句
  • Like organisms, viruses have variants, generally called strains. 与其他生物一样,病毒也有变种,一般称之为株系。 来自辞典例句
8 steering 3hRzbi     
  • He beat his hands on the steering wheel in frustration. 他沮丧地用手打了几下方向盘。
  • Steering according to the wind, he also framed his words more amicably. 他真会看风使舵,口吻也马上变得温和了。
9 determined duszmP     
  • I have determined on going to Tibet after graduation.我已决定毕业后去西藏。
  • He determined to view the rooms behind the office.他决定查看一下办公室后面的房间。
TAG标签: cancer gene flaw ovary