文章来源:未知 文章作者:meng 发布时间:2009-12-25 07:01 字体: [ ]  进入论坛

Scientists say they have found proof that another "bad" type of cholesterol1 contributes to heart disease.


Home testing <a href=kits2 can check for high cholesterol, but not Lp(a) specifically" width="226" height="170" src="/upimg/091225/4_070254_1.jpg" />
Home testing kits can check for high cholesterol, but not Lp(a) specifically

Unlike the well-known LDL低密度脂蛋白 cholesterol, lipoprotein脂蛋白(a) or Lp(a) cannot be controlled by cutting down on dietary fats or taking a statin抑制素,他汀类 drug.

But researchers say high levels do not carry the same risk as LDL.

And other drugs might work to minimise its effects, they told the New England Journal of Medicine.

LDL is considered the aggressive tiger of the cholesterol world, furring the arteries3 and greatly increasing heart risk. Scientist believe Lp(a), which is inherited, is more of a pussycat猫,有毛且柔软的东西, although it does appear to upset blood clotting血液凝结.

Inherent risk

The researchers used gene-chip technology to scan DNA5 that they knew from previous studies were potential "hotspots" for heart disease risk. This analysis revealed the two genetic6 culprits犯人,罪犯.

Professor Martin Farrall, lead author of the study carried out at Oxford7 University, said one in six people carries one or more of the genes8 for Lp(a).

He said: "The increase in risk to people from high Lp(a) levels is significantly less severe than the risk from high LDL cholesterol胆固醇 levels.

"So Lp(a) doesn't trump9 LDL, which has a larger impact and which we can already control pretty effectively.

"The hope now is that by targeting both we could get even better risk reduction."

Some existing drugs, such as Niacin烟酸,尼克酸, and others coming on to the market, such as CETP-inhibitors, lower Lp(a) as well as LDL cholesterol.

Professor Peter Weissberg of the British Heart Foundation, which funded the study, said the findings were useful but urged people not to be alarmed by them.

"They highlight the importance of trying to lower Lp(a), which will spark new efforts to design a medicine to achieve this effectively.

"And they reveal clues that open a new avenue for research to decipher解释 how heart disease develops.

"But LDL is still the type of cholesterol to be more concerned about."

Fats from food are turned into cholesterol by the liver. There are different types but some, such as LDL, are known as "bad" cholesterol. They can lead to a build-up in the body's cells.

Prof Weissberg said everyone could reduce their risk of heart disease by eating a healthy balanced diet, being physically10 active and avoiding smoking.


1 cholesterol qrzzV     
  • There is cholesterol in the cell of body.人体细胞里有胆固醇。
  • They are determining the serum-protein and cholesterol levels.他们正在测定血清蛋白和胆固醇的浓度。
2 kits e16d4ffa0f9467cd8d2db7d706f0a7a5     
衣物和装备( kit的名词复数 ); 成套用品; 配套元件
  • Keep your kits closed and locked when not in use. 不用的话把你的装备都锁好放好。
  • Gifts Articles, Toy and Games, Wooden Toys, Puzzles, Craft Kits. 采购产品礼品,玩具和游戏,木制的玩具,智力玩具,手艺装备。
3 arteries 821b60db0d5e4edc87fdf5fc263ba3f5     
n.动脉( artery的名词复数 );干线,要道
  • Even grafting new blood vessels in place of the diseased coronary arteries has been tried. 甚至移植新血管代替不健康的冠状动脉的方法都已经试过。 来自《简明英汉词典》
  • This is the place where the three main arteries of West London traffic met. 这就是伦敦西部三条主要交通干线的交汇处。 来自《简明英汉词典》
4 clotting 9eca3747f25ae6f0d50d00d5b71d5d7d     
v.凝固( clot的现在分词 );烧结
  • The study was also based only on the one anti-clotting drug. 所用抗血栓药物也仅限于一种。 来自互联网
  • A plasma protein that is converted into thrombin during blood clotting. 凝血原酶一种血浆蛋白质,在血液凝聚时转化成凝血''。'酵'。''''。'素'。''。 来自互联网
5 DNA 4u3z1l     
(缩)deoxyribonucleic acid 脱氧核糖核酸
  • DNA is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
  • Gene mutations are alterations in the DNA code.基因突变是指DNA密码的改变。
6 genetic PgIxp     
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
7 Oxford Wmmz0a     
  • At present he has become a Professor of Chemistry at Oxford.他现在已是牛津大学的化学教授了。
  • This is where the road to Oxford joins the road to London.这是去牛津的路与去伦敦的路的汇合处。
8 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
9 trump LU1zK     
  • He was never able to trump up the courage to have a showdown.他始终鼓不起勇气摊牌。
  • The coach saved his star player for a trump card.教练保留他的明星选手,作为他的王牌。
10 physically iNix5     
  • He was out of sorts physically,as well as disordered mentally.他浑身不舒服,心绪也很乱。
  • Every time I think about it I feel physically sick.一想起那件事我就感到极恶心。