How greens may protect the heart 研究:绿色蔬菜如何保护心脏
文章来源:未知 文章作者:meng 发布时间:2009-09-05 06:02 字体: [ ]  进入论坛
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Researchers have discovered a possible reason why green vegetables such as broccoli1, cabbage and cauliflower are good for the heart.

研究人员发现为什么绿色蔬菜,像绿菜花、卷心菜、花椰菜对心脏有好处。

Sulforapane is found in broccoli and brussel <a href=sprouts2" width="226" border="0" src="/upimg/090905/4_061538_1.jpg" />
Sulforapane is found in broccoli and brussel sprouts

Their work suggests a chemical found in the vegetables can boost a natural defence mechanism3 to protect arteries4 from disease.

The Imperial College London team hope their work could lead to new dietary treatments to prevent heart problems.

Details appear in Arteriosclerosis Thrombosis and Vascular5 Biology.

Much heart disease is caused by the build up of fatty plaques7(匾,饰板) in the arteries known as atherosclerosis(动脉硬化).

However, arteries do not get clogged8 up with these plaques in a uniform way.

Bends and branches of blood vessels9 - where blood flow is disrupted and can be sluggish10(懒惰的,迟钝的) - are much more prone11 to the build-up.

The latest study has shown that a protein that usually protects against plaque6 build up called Nrf2 is inactive in areas of arteries that are prone to disease.

However, it also found that treatment with a chemical found in green "brassica(芸苔)" vegetables such as broccoli can activate12 Nrf2 in these disease-prone regions.

Lead researcher Dr Paul Evans said: "We found that the innermost(内心的,秘密的) layer of cells at branches and bends of arteries lack the active form of Nrf2, which may explain why they are prone to inflammation(发炎,红肿) and disease.

"Treatment with the natural compound sulforaphane reduced inflammation at the high-risk areas by 'switching on' Nrf2.

"Sulforaphane is found naturally in broccoli, so our next steps include testing whether simply eating broccoli, or other vegetables in their 'family', has the same protective effect.

"We also need to see if the compound can reduce the progression of disease in affected13 arteries."

Targeted approaches

Professor Peter Weissberg, medical director of the British Heart Foundation, which funded the research, said: "These fascinating findings provide a possible mechanism by which eating vegetables protects against heart disease.

"As well as adding evidence to support the importance of eating 'five-a-day', the biochemistry(生物化学) revealed in this research could lead to more targeted dietary or medical approaches to prevent or lessen14 disease that leads to heart attacks and strokes."

Using normal mice, and mice engineered to lack the Nrf2 protein, the research found that in straight sections of arteries Nrf2 was present in the endothelial(内皮的) 'lining15' cells.

Through its action on other proteins, it prevented the cells from becoming inflamed16, an early stage in the development of atherosclerosis.

In the lining cells of disease-prone sites - such as bending or branched arteries - Nrf2 was attached to a protein that made it inactive. This stifled17 its protective properties.

But the addition of sulforaphane re-activated Nrf2 in the disease-prone regions of the artery18, restoring the cells' ability to protect themselves from becoming inflamed.

The researchers believe that this will enable these artery regions to remain healthy for longer, or even reduce the progression of existing disease.



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1 broccoli 1sbzm     
n.绿菜花,花椰菜
参考例句:
  • She grew all the broccoli plants from seed.这些花椰菜都是她用种子培育出来的。
  • They think broccoli is only green and cauliflower is only white.他们认为西兰花只有绿色的,而菜花都是白色的。
2 sprouts 7250d0f3accee8359a172a38c37bd325     
n.新芽,嫩枝( sprout的名词复数 )v.发芽( sprout的第三人称单数 );抽芽;出现;(使)涌现出
参考例句:
  • The wheat sprouts grew perceptibly after the rain. 下了一场雨,麦苗立刻见长。 来自《现代汉英综合大词典》
  • The sprouts have pushed up the earth. 嫩芽把土顶起来了。 来自《现代汉英综合大词典》
3 mechanism zCWxr     
n.机械装置;机构,结构
参考例句:
  • The bones and muscles are parts of the mechanism of the body.骨骼和肌肉是人体的组成部件。
  • The mechanism of the machine is very complicated.这台机器的结构是非常复杂的。
4 arteries 821b60db0d5e4edc87fdf5fc263ba3f5     
n.动脉( artery的名词复数 );干线,要道
参考例句:
  • Even grafting new blood vessels in place of the diseased coronary arteries has been tried. 甚至移植新血管代替不健康的冠状动脉的方法都已经试过。 来自《简明英汉词典》
  • This is the place where the three main arteries of West London traffic met. 这就是伦敦西部三条主要交通干线的交汇处。 来自《简明英汉词典》
5 vascular cidw6     
adj.血管的,脉管的
参考例句:
  • The mechanism of this anomalous vascular response is unknown.此种不规则的血管反应的机制尚不清楚。
  • The vascular changes interfere with diffusion of nutrients from plasma into adjacent perivascular tissue and cells.这些血管变化干扰了营养物质从血浆中向血管周围邻接的组织和细胞扩散。
6 plaque v25zB     
n.饰板,匾,(医)血小板
参考例句:
  • There is a commemorative plaque to the artist in the village hall.村公所里有一块纪念该艺术家的牌匾。
  • Some Latin words were engraved on the plaque. 牌匾上刻着些拉丁文。
7 plaques cc23efd076b2c24f7ab7a88b7c458b4f     
(纪念性的)匾牌( plaque的名词复数 ); 纪念匾; 牙斑; 空斑
参考例句:
  • Primary plaques were detectable in 16 to 20 hours. 在16到20小时内可查出原发溶斑。
  • The gondoliers wore green and white livery and silver plaques on their chests. 船夫们穿着白绿两色的制服,胸前别着银质徽章。
8 clogged 0927b23da82f60cf3d3f2864c1fbc146     
(使)阻碍( clog的过去式和过去分词 ); 淤滞
参考例句:
  • The narrow streets were clogged with traffic. 狭窄的街道上交通堵塞。
  • The intake of gasoline was stopped by a clogged fuel line. 汽油的注入由于管道阻塞而停止了。
9 vessels fc9307c2593b522954eadb3ee6c57480     
n.血管( vessel的名词复数 );船;容器;(具有特殊品质或接受特殊品质的)人
参考例句:
  • The river is navigable by vessels of up to 90 tons. 90 吨以下的船只可以从这条河通过。 来自《简明英汉词典》
  • All modern vessels of any size are fitted with radar installations. 所有现代化船只都有雷达装置。 来自《现代汉英综合大词典》
10 sluggish VEgzS     
adj.懒惰的,迟钝的,无精打采的
参考例句:
  • This humid heat makes you feel rather sluggish.这种湿热的天气使人感到懒洋洋的。
  • Circulation is much more sluggish in the feet than in the hands.脚部的循环比手部的循环缓慢得多。
11 prone 50bzu     
adj.(to)易于…的,很可能…的;俯卧的
参考例句:
  • Some people are prone to jump to hasty conclusions.有些人往往作出轻率的结论。
  • He is prone to lose his temper when people disagree with him.人家一不同意他的意见,他就发脾气。
12 activate UJ2y0     
vt.使活动起来,使开始起作用
参考例句:
  • We must activate the youth to study.我们要激励青年去学习。
  • These push buttons can activate the elevator.这些按钮能启动电梯。
13 affected TzUzg0     
adj.不自然的,假装的
参考例句:
  • She showed an affected interest in our subject.她假装对我们的课题感到兴趣。
  • His manners are affected.他的态度不自然。
14 lessen 01gx4     
vt.减少,减轻;缩小
参考例句:
  • Regular exercise can help to lessen the pain.经常运动有助于减轻痛感。
  • They've made great effort to lessen the noise of planes.他们尽力减小飞机的噪音。
15 lining kpgzTO     
n.衬里,衬料
参考例句:
  • The lining of my coat is torn.我的外套衬里破了。
  • Moss makes an attractive lining to wire baskets.用苔藓垫在铁丝篮里很漂亮。
16 inflamed KqEz2a     
adj.发炎的,红肿的v.(使)变红,发怒,过热( inflame的过去式和过去分词 )
参考例句:
  • His comments have inflamed teachers all over the country. 他的评论激怒了全国教师。
  • Her joints are severely inflamed. 她的关节严重发炎。 来自《简明英汉词典》
17 stifled 20d6c5b702a525920b7425fe94ea26a5     
(使)窒息, (使)窒闷( stifle的过去式和过去分词 ); 镇压,遏制; 堵
参考例句:
  • The gas stifled them. 煤气使他们窒息。
  • The rebellion was stifled. 叛乱被镇压了。
18 artery 5ekyE     
n.干线,要道;动脉
参考例句:
  • We couldn't feel the changes in the blood pressure within the artery.我们无法感觉到动脉血管内血压的变化。
  • The aorta is the largest artery in the body.主动脉是人体中的最大动脉。
TAG标签: heart green protect
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