'Magnetic' stem cells for hearts “磁化”干细胞有助治疗心脏
文章来源:未知 文章作者:meng 发布时间:2009-08-18 06:56 字体: [ ]  进入论坛

Heart attacks and other vascular1 injuries could eventually be treated using regular injections of magnetised stem cells, experts say.


The stem cells can repair the heart
The stem cells can repair the heart's damaged arteries2

In animal trials, the cutting-edge treatment delivered the healing cells to the precise(精确地,准确地) site of damage where their help was needed.

Although human tests are needed, a similar magnetic(有磁性的,有吸引力的) approach has been used to guide cancer therapies.

The expert US journal Cardiovascular Interventions3 reports the findings.

Targeted treatment

The idea behind the targeted therapy is to get as many of the reparative stem cells as possible to the area of damage.

To achieve this the UK scientists coated the stem cells with minute magnetic particles.

When these stem cells were injected into the blood stream it was then possible to control their movement using a magnet(磁铁,磁体).

In trials, the magnetic targeting led to a five-fold increase in cell localisation at a site of vascular(血管的,脉管的) injury in rats.

These same magnetic nanoparticles(纳米微粒) are already approved in the US where they are routinely used as an agent to make MRI scans clearer to read.

Senior author of the study Dr Mark Lythgoe, of University College London, said this meant human trials could begin within the next few years.

He said: "It's feasible(可行的,可能的) that heart attacks and other vascular injuries could eventually be treated using regular injections of magnetised stem cells.

"The technology could be adapted to localise cells in other organs and provide a useful tool for the systemic injection of all manner of cell therapies.

"And it's not just limited to cells - by focusing tagged antibodies or viruses using this method, cancerous tumours4 could be much more specifically targeted."

The British Heart Foundation's Professor Peter Weissberg said: "This encouraging research shows that nanomagnets could be used to help therapeutic5 stem cells reach specific areas of the body, particularly inside blood vessels6 where the blood is flowing fast and at high pressure.

"It is hoped that this strategy could be used to help these cells home-in to the sites of diseased tissue(组织) and improve the chances of repairing it.

"We await further research to find out if, as well as increasing the chances of these cells getting to where they are needed, this strategy can actually speed up the repair process."


1 vascular cidw6     
  • The mechanism of this anomalous vascular response is unknown.此种不规则的血管反应的机制尚不清楚。
  • The vascular changes interfere with diffusion of nutrients from plasma into adjacent perivascular tissue and cells.这些血管变化干扰了营养物质从血浆中向血管周围邻接的组织和细胞扩散。
2 arteries 821b60db0d5e4edc87fdf5fc263ba3f5     
n.动脉( artery的名词复数 );干线,要道
  • Even grafting new blood vessels in place of the diseased coronary arteries has been tried. 甚至移植新血管代替不健康的冠状动脉的方法都已经试过。 来自《简明英汉词典》
  • This is the place where the three main arteries of West London traffic met. 这就是伦敦西部三条主要交通干线的交汇处。 来自《简明英汉词典》
3 interventions b4e9b73905db5b0213891229ce84fdd3     
n.介入,干涉,干预( intervention的名词复数 )
  • Economic analysis of government interventions deserves detailed discussion. 政府对经济的干预应该给予充分的论述。 来自辞典例句
  • The judge's frequent interventions made a mockery of justice. 法官的屡屡干预是对正义的践踏。 来自互联网
4 tumours 6654305f758b5b5576a74cb007e8d079     
肿瘤( tumour的名词复数 )
  • Blood vessels develop abnormally in cancer tumours. 在癌肿瘤中血管出现不正常。
  • This apparatus scans patients' brains for tumours. 这台仪器扫描检查病人的脑瘤。
5 therapeutic sI8zL     
  • Therapeutic measures were selected to fit the patient.选择治疗措施以适应病人的需要。
  • When I was sad,music had a therapeutic effect.我悲伤的时候,音乐有治疗效力。
6 vessels fc9307c2593b522954eadb3ee6c57480     
n.血管( vessel的名词复数 );船;容器;(具有特殊品质或接受特殊品质的)人
  • The river is navigable by vessels of up to 90 tons. 90 吨以下的船只可以从这条河通过。 来自《简明英汉词典》
  • All modern vessels of any size are fitted with radar installations. 所有现代化船只都有雷达装置。 来自《现代汉英综合大词典》
TAG标签: magnetic heart stem cell