HIV circumcision study ends early
文章来源:未知 文章作者:meng 发布时间:2009-07-18 07:16 字体: [ ]  进入论坛

Circumcising men who already have HIV does not protect their female partners from the virus, a study in Uganda has found.


Condoms are still necessary to stop the spread of HIV
Condoms are still necessary to stop the spread of HIV

Circumcision(包皮环切术) is known to protect men from acquiring HIV.

But the research, from the Lancet, showed no benefit in those who already had the virus and was stopped early because of the continued risk to women.

Experts say HIV-positive men should still be offered circumcision, but also warned to use condoms(避孕套).

The US researchers, from Johns Hopkins School of Public Health in Baltimore, say not offering the procedure to men with HIV would stigmatise(使蒙上罪名,责难) them.

Other experts say it could become a "sign" of whether a man was HIV positive or not.


Previous research had suggested women could be protected from HIV if their partner was circumcised.

In this study, 922 uncircumcised, HIV-infected, asymptomatic(无症状的) men aged1 15-49 years with HIV were enrolled2 in the Rakai district of Uganda.

Men were then selected to have immediate3 circumcision (474 men) or to be given circumcision after two years (448 men).

Almost 170 uninfected female partners of the men were also enrolled, and followed up at six, 12, and 24 months.

However, the trial was ended early because of what the researchers called the "futility(无用,无价值)" of carrying on, and the second group were not circumcised.

Only 92 couples in the immediate circumcision group and 67 in the control group were included in the final analysis.

It was found that a higher proportion of women were infected with HIV in the intervention4(插入,介入) group (18%) versus5 the control group (12%).

The researchers suggest the higher transmission rate could have been due to couples resuming their sex lives before the circumcision would have properly healed.


Writing in the Lancet, the team led by Dr Maria Wawer said: "Circumcision of HIV-infected men did not reduce HIV transmission to female partners over 24 months; longer-term effects could not be assessed."

They said it was not sensible to recommend men with HIV should not be circumcised, or that there should be any down-scaling of circumcision programmes, because of the overall benefits to both uninfected men and to women.

But they added: "It's inevitable6 that men who are infected with HIV will also require to be circumcised, partly to avoid stigmatisation.

"The findings suggest that strict adherence7(附著,固守) to sexual abstinence(节制,禁食) during wound healing, and continuous condom use thereafter must be strongly promoted when HIV-infected men receive circumcision."

They suggest a solution would be to circumcise as early as possible.

"Circumcising infants and young boys before their sexual debut8 would mitigate9(镇静,缓和) the challenge of male circumcision in HIV-infected men.

"However, this strategy would require careful consideration of issues relating to parental10 consent(家长同意) and the minor's consent."

In an editorial in the journal, a team from the University of Washington in Seattle, led by Dr Jared Baeten said the findings should not "hinder" the use of circumcision in HIV prevention programmes.

Victoria Sheard of the UK's Terrence Higgins Trust, said: "Circumcision is most often used as an HIV prevention tool in the developing world, where it can be difficult to get hold of condoms.

"However, it shouldn't be seen as a stand-alone strategy.

"Women are disproportionately(不成比例地) affected11 by HIV in sub-Saharan Africa, and - as this study shows - will still be at risk whether their partners are circumcised or not.

"The best way to guard against HIV is by always using a condom, so more work is needed to ensure adequate protection is available for those who need it the most."


1 aged 6zWzdI     
  • He had put on weight and aged a little.他胖了,也老点了。
  • He is aged,but his memory is still good.他已年老,然而记忆力还好。
2 enrolled ff7af27948b380bff5d583359796d3c8     
adj.入学登记了的v.[亦作enrol]( enroll的过去式和过去分词 );登记,招收,使入伍(或入会、入学等),参加,成为成员;记入名册;卷起,包起
  • They have been studying hard from the moment they enrolled. 从入学时起,他们就一直努力学习。 来自《简明英汉词典》
  • He enrolled with an employment agency for a teaching position. 他在职业介绍所登了记以谋求一个教师的职位。 来自《简明英汉词典》
3 immediate aapxh     
  • His immediate neighbours felt it their duty to call.他的近邻认为他们有责任去拜访。
  • We declared ourselves for the immediate convocation of the meeting.我们主张立即召开这个会议。
4 intervention e5sxZ     
  • The government's intervention in this dispute will not help.政府对这场争论的干预不会起作用。
  • Many people felt he would be hostile to the idea of foreign intervention.许多人觉得他会反对外来干预。
5 versus wi7wU     
  • The big match tonight is England versus Spain.今晚的大赛是英格兰对西班牙。
  • The most exciting game was Harvard versus Yale.最富紧张刺激的球赛是哈佛队对耶鲁队。
6 inevitable 5xcyq     
  • Mary was wearing her inevitable large hat.玛丽戴着她总是戴的那顶大帽子。
  • The defeat had inevitable consequences for British policy.战败对英国政策不可避免地产生了影响。
7 adherence KyjzT     
  • He was well known for his adherence to the rules.他因遵循这些规定而出名。
  • The teacher demanded adherence to the rules.老师要求学生们遵守纪律。
8 debut IxGxy     
  • That same year he made his Broadway debut, playing a suave radio journalist.在那同一年里,他初次在百老汇登台,扮演一个温文而雅的电台记者。
  • The actress made her debut in the new comedy.这位演员在那出新喜剧中首次登台演出。
9 mitigate EjRyf     
  • The government is trying to mitigate the effects of inflation.政府正试图缓和通货膨胀的影响。
  • Governments should endeavour to mitigate distress.政府应努力缓解贫困问题。
10 parental FL2xv     
  • He encourages parental involvement in the running of school.他鼓励学生家长参与学校的管理。
  • Children always revolt against parental disciplines.孩子们总是反抗父母的管束。
11 affected TzUzg0     
  • She showed an affected interest in our subject.她假装对我们的课题感到兴趣。
  • His manners are affected.他的态度不自然。
TAG标签: HIV circumcision