转移性黑素瘤基因疗法在鼠类实验中获得成功
文章来源:未知 文章作者:meng 发布时间:2010-11-19 03:25 字体: [ ]  进入论坛
(单词翻译:双击或拖选)

A potent1(有效的,强有力的) anti-tumor gene2 introduced into mice with metastatic(转移性的,变形的) melanoma(黑素瘤,胎记瘤) has resulted in permanent immune reconfiguration and produced a complete remission(缓解,豁免) of their cancer, according to an article to be published in the December 2010 issue of the Journal of Clinical Investigation3. The online version is now available. Indiana University School of Medicine researchers used a modified lentivirus(慢病毒) to introduce a potent anti-melanoma T cell receptor gene into the hematopoietic(造血的) stem cells of mice. Hematopoietic stem cells are the bone marrow4 cells that produce all blood and immune system cells.

The T cell gene, which recognizes a specific protein found on the surface of melanoma, was isolated5 and cloned from a patient with melanoma. The gene-modified stems cells were then transplanted back into hosts and found to eradicate(根除,灭绝) metastatic melanoma for the lifetime of the mice.

"We found that the transplantation of gene-modified hematopoietic stem cells results in a new host immune system and the complete elimination7 of tumor," reported Christopher E. Touloukian, M.D., an assistant professor of surgery and immunology at the IU School of Medicine and a member of the Indiana University Melvin and Bren Simon Cancer Center. "To date, cancer immunotherapies have been hampered8(阻碍,限制) by limited and diminishing immune responses over time. We believe this type of translational model opens new doors for patients with melanoma and potentially other cancers by taking advantage of the potent regenerative capacity of hematopoietic stem cells and new advances in gene therapy."

This research was funded by a National Institutes of Health grant.

It has paved the way for a new clinical trial in humans funded by the V Foundation for Cancer Research. The pilot phase I trial will involve treatment of 12 patients and focus primarily on the safety and efficacy of the therapy, said Dr. Touloukian, who is the senior author on the JCI paper and the principal investigator9 for the clinical study. The clinical trial is expected to begin accruing10 patients by late 2011.

In 2010, more than 68,000 patients will be diagnosed with melanoma and the disease will be associated with approximately 9,000 deaths. The state of Indiana has the 11th highest rate of melanoma incidence of all 50 states. Current treatments for metastatic melanoma, though exciting and innovative11, have been highly toxic12 and largely unsuccessful with the most patients dying within 6 to 12 months after diagnosis13.



点击收听单词发音收听单词发音  

1 potent C1uzk     
adj.强有力的,有权势的;有效力的
参考例句:
  • The medicine had a potent effect on your disease.这药物对你的病疗效很大。
  • We must account of his potent influence.我们必须考虑他的强有力的影响。
2 gene WgKxx     
n.遗传因子,基因
参考例句:
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
3 investigation MRKzq     
n.调查,调查研究
参考例句:
  • In an investigation,a new fact became known, which told against him.在调查中新发现了一件对他不利的事实。
  • He drew the conclusion by building on his own investigation.他根据自己的调查研究作出结论。
4 marrow M2myE     
n.骨髓;精华;活力
参考例句:
  • It was so cold that he felt frozen to the marrow. 天气太冷了,他感到寒冷刺骨。
  • He was tired to the marrow of his bones.他真是累得筋疲力尽了。
5 isolated bqmzTd     
adj.与世隔绝的
参考例句:
  • His bad behaviour was just an isolated incident. 他的不良行为只是个别事件。
  • Patients with the disease should be isolated. 这种病的患者应予以隔离。
6 eradicate Ui1zn     
v.根除,消灭,杜绝
参考例句:
  • These insects are very difficult to eradicate.这些昆虫很难根除。
  • They are already battling to eradicate illnesses such as malaria and tetanus.他们已经在努力消灭疟疾、破伤风等疾病。
7 elimination 3qexM     
n.排除,消除,消灭
参考例句:
  • Their elimination from the competition was a great surprise.他们在比赛中遭到淘汰是个很大的意外。
  • I was eliminated from the 400 metres in the semi-finals.我在400米半决赛中被淘汰。
8 hampered 3c5fb339e8465f0b89285ad0a790a834     
妨碍,束缚,限制( hamper的过去式和过去分词 )
参考例句:
  • The search was hampered by appalling weather conditions. 恶劣的天气妨碍了搜寻工作。
  • So thought every harassed, hampered, respectable boy in St. Petersburg. 圣彼德堡镇的那些受折磨、受拘束的体面孩子们个个都是这么想的。
9 investigator zRQzo     
n.研究者,调查者,审查者
参考例句:
  • He was a special investigator for the FBI.他是联邦调查局的特别调查员。
  • The investigator was able to deduce the crime and find the criminal.调查者能够推出犯罪过程并锁定罪犯。
10 accruing 3047ff5f2adfcc90573a586d0407ec0d     
v.增加( accrue的现在分词 );(通过自然增长)产生;获得;(使钱款、债务)积累
参考例句:
  • economic benefits accruing to the country from tourism 旅游业为该国带来的经济效益
  • The accruing on a security since the previous coupon date. 指证券自上次付息日以来所累积的利息。 来自互联网
11 innovative D6Vxq     
adj.革新的,新颖的,富有革新精神的
参考例句:
  • Discover an innovative way of marketing.发现一个创新的营销方式。
  • He was one of the most creative and innovative engineers of his generation.他是他那代人当中最富创造性与革新精神的工程师之一。
12 toxic inSwc     
adj.有毒的,因中毒引起的
参考例句:
  • The factory had accidentally released a quantity of toxic waste into the sea.这家工厂意外泄漏大量有毒废物到海中。
  • There is a risk that toxic chemicals might be blasted into the atmosphere.爆炸后有毒化学物质可能会进入大气层。
13 diagnosis GvPxC     
n.诊断,诊断结果,调查分析,判断
参考例句:
  • His symptoms gave no obvious pointer to a possible diagnosis.他的症状无法作出明确的诊断。
  • The engineer made a complete diagnosis of the bridge's collapse.工程师对桥的倒塌做一次彻底的调查分析。
TAG标签: cells melanoma cancer gene
发表评论
请自觉遵守互联网相关的政策法规,严禁发布色情、暴力、反动的言论。
评价:
表情:
验证码:点击我更换图片