健康高效男用避孕药或将问世
文章来源:未知 文章作者:enread 发布时间:2012-08-20 05:57 字体: [ ]  进入论坛
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Researchers have finally found a compound that may offer the first effective and hormone-free birth control pill for men. The study in the August 17th Cell, a Cell Press publication, shows that the small molecule1 makes male mice reversibly infertile2 without putting a damper on(抑制,扫兴) their sex drive. When the animals stop taking this new form of birth control, their sperm3 rebound4 and they are again able to sire(生产) perfectly5 healthy offspring. "This compound produces a rapid and reversible decrease in sperm count and motility with profound effects on fertility," said James Bradner of the Dana-Farber Cancer Institute, the lead author of the study.
 
A male birth control pill hasn't been easy to come by in large part because of the challenge of getting any drug across the blood:testis barrier, where it can reach the sperm-generating cells. That lack of contraceptive alternatives for men is partially6 responsible for the high rate of unplanned pregnancies7. Despite the unsatisfactory options for male contraception, nearly one-third of couples rely on male-directed birth control methods.
 
Known as JQ1, the compound developed in the Bradner lab works by targeting a testis-specific protein called BRDT that is essential for fertility. When mice are given the BRDT-inhibiting molecule, they begin producing fewer sperm and those sperm they do produce don't swim as well.
 
"This is a good reason to get excited about low sperm counts," said Martin Matzuk of Baylor College of Medicine, another author of the report.
 
Mating studies confirm that JQ1 indeed works as effective contraception. Even better, those effects are complete and reversible and without adverse8 consequences for the animals' testosterone levels or behavior. The small molecule also comes without any apparent adverse effects on the males' future offspring.
 
"There has not been a new reversible contraceptive for men since the development of the condom, centuries ago," notes William Bremner from the University of Washington, Seattle in an accompanying commentary in which he refers to Matzuk and Bradner's contraceptive method as "a breakthrough new approach."
 
"We envision that our discoveries can be completely translated to men, providing a novel and efficacious(有效的) strategy for a male contraceptive," the researchers wrote, noting the high degree of conservation between human and mouse BRDT proteins.


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1 molecule Y6Tzn     
n.分子,克分子
参考例句:
  • A molecule of water is made up of two atoms of hygrogen and one atom of oxygen.一个水分子是由P妈?f婘??妈?成的。
  • This gives us the structural formula of the molecule.这种方式给出了分子的结构式。
2 infertile u71xE     
adj.不孕的;不肥沃的,贫瘠的
参考例句:
  • Plants can't grow well in the infertile land.在贫瘠的土地上庄稼长不好。
  • Nobody is willing to till this infertile land.这块薄田没有人愿意耕种。
3 sperm jFOzO     
n.精子,精液
参考例句:
  • Only one sperm fertilises an egg.只有一个精子使卵子受精。
  • In human reproduction,one female egg is usually fertilized by one sperm.在人体生殖过程中,一个精子使一个卵子受精。
4 rebound YAtz1     
v.弹回;n.弹回,跳回
参考例句:
  • The vibrations accompanying the rebound are the earth quake.伴随这种回弹的振动就是地震。
  • Our evil example will rebound upon ourselves.我们的坏榜样会回到我们自己头上的。
5 perfectly 8Mzxb     
adv.完美地,无可非议地,彻底地
参考例句:
  • The witnesses were each perfectly certain of what they said.证人们个个对自己所说的话十分肯定。
  • Everything that we're doing is all perfectly above board.我们做的每件事情都是光明正大的。
6 partially yL7xm     
adv.部分地,从某些方面讲
参考例句:
  • The door was partially concealed by the drapes.门有一部分被门帘遮住了。
  • The police managed to restore calm and the curfew was partially lifted.警方设法恢复了平静,宵禁部分解除。
7 pregnancies 2fedeb45162c233ee9e28d81888a2d2c     
怀孕,妊娠( pregnancy的名词复数 )
参考例句:
  • Since the wartime population needed replenishment, pregnancies were a good sign. 最后一桩倒不失为好现象,战时人口正该补充。
  • She's had three pregnancies in four years. 她在四年中怀孕叁次。
8 adverse 5xBzs     
adj.不利的;有害的;敌对的,不友好的
参考例句:
  • He is adverse to going abroad.他反对出国。
  • The improper use of medicine could lead to severe adverse reactions.用药不当会产生严重的不良反应。
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