Researchers have long chronicled what goes wrong in the brains of older people with dementia. But Northwestern Medicine researcher Emily Rogalski wondered what goes right in the brains of the elderly who still have terrific memories. And, do those people -- call them cognitive¹ SuperAgers -- even exist? Rogalski's new study has for the first time identified an elite² group of elderly people age 80 and older whose memories are as sharp as people 20 to 30 years younger than them. And on 3-D MRI scans, the SuperAger participants' brains appear as young -- and one brain region was even bigger -- than the brains of the middle-aged³ participants.

 

She was astounded⁴ by the vitality⁵ of the SuperAgers' cortex -- the outer layer of the brain important for memory, attention and other thinking abilities. Theirs was much thicker than the cortex of the normal group of elderly 80 and older (whose showed significant thinning) and closely resembled the cortex size of participants ages 50 to 65, considered the middle-aged group of the study.

 

"These findings are remarkable⁶ given the fact that grey matter or brain cell loss is a common part of normal aging," said Rogalski, the principal investigator⁷ of the study and an assistant research professor at the Cognitive Neurology and Alzheimer's Disease Center at Northwestern University Feinberg School of Medicine.

 

Rogalski is senior author of the paper, which is published in the Journal of the International Neuropsychological Society.

 

By identifying older people who seem to be uniquely protected from the deterioration⁸ of memory and atrophy⁹（萎缩） of brain cells that accompanies aging, Rogalski hopes to unlock the secrets of their youthful brains. Those discoveries may be applied¹⁰ to protect others from memory loss or even Alzheimer's disease.

 

"By looking at a really healthy older brain, we can start to deduce how SuperAgers are able to maintain their good memory," Rogalski said. "Many scientists study what's wrong with the brain, but maybe we can ultimately help Alzheimer's patients by figuring out what goes right in the brain of SuperAgers. What we learn from these healthy brains may inform our strategies for improving quality of life for the elderly and for combatting Alzheimer's disease."

 

By measuring the thickness of the cortex -- the outer layer of the brain where neurons (brain cells) reside -- Rogalski has a sense of how many brain cells are left.

 

"We can't actually count them, but the thickness of the outer cortex of the brain provides an indirect measure of the health of the brain," she said. "A thicker cortex, suggests a greater number of neurons."

 

In another region deep in the brain, the anterior¹¹（前面的） cingulate of SuperAger participants' was actually thicker than in the 50 to 65 year olds.

 

"This is pretty incredible," Rogalski said. "This region is important for attention. Attention supports memory. Perhaps the SuperAgers have really keen attention and that supports their exceptional memories."

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