与抑郁症有关的一个基因被发现
文章来源:未知 文章作者:enread 发布时间:2012-01-05 05:28 字体: [ ]  进入论坛
(单词翻译:双击或拖选)

Psychiatric disorders2 can be described on many levels, the most traditional of which are subjective3 descriptions of the experience of being depressed4 and the use of rating scales that quantify depressive symptoms. Over the past two decades, research has developed other strategies for describing the biological underpinnings of depression, including volumetric brain measurements using magnetic resonance5 imaging (MRI) and the patterns of gene6 expression in white blood cells. During this period, a great deal of research has attempted to characterize the genes7 that cause depression as reflected in rating scales of mood states, alterations8 in brain structure and function as measured by MRI, and gene expression patterns in post-mortem brain tissue from people who had depression.

So what would happen if one tried to find the gene or genes that explained the "whole picture" by combining all of the different types of information that one could collect? This is exactly what was attempted by Dr. David Glahn, of Yale University and Hartford Hospital's Institute of Living, and his colleagues.

"They have provided a very exciting strategy for uniting the various types of data that we collect in clinical research in studies attempting to identify risk genes," said Dr. John Krystal, Editor of Biological Psychiatry9.

Their work localized a gene, called RNF123, which may play a role in major depression.

They set out with two clear goals: to describe a new method for ranking measures of brain structure and function on their genetic10 'importance' for an illness, and then to localize a candidate gene for major depression.

"We were trying to come up with a way that could generally be used to link biological measurements to (psychiatric) disease risk," said Dr. John Blangero, director of the AT&T Genomics Computing11 Center at the Texas Biomedical Research Institute. "And in our first application of this, in relation to major depressive disorder1, we've actually come up with something quite exciting."

While RNF123 hasn't previously12 been linked to depression, it has been shown to affect a part of the brain called the hippocampus(海马) , which is altered in people with major depression.

"We assume that the biological measures are closer mechanistically to the underlying13 disease processesin the brain. Yet, ultimately we are interested in the subjective experiences and functional14 impairment associated with mental illness," added Krystal. "The approach employed in this study may help to make use of all of this information, hopefully increasing our ability to identify genes that cause depression or might be targeted for its treatment."

Glahn said, "We still have more work before we truly believe this is a home-run gene, but we've got a really good candidate. Even that has been tough to do in depression."



点击收听单词发音收听单词发音  

1 disorder Et1x4     
n.紊乱,混乱;骚动,骚乱;疾病,失调
参考例句:
  • When returning back,he discovered the room to be in disorder.回家后,他发现屋子里乱七八糟。
  • It contained a vast number of letters in great disorder.里面七零八落地装着许多信件。
2 disorders 6e49dcafe3638183c823d3aa5b12b010     
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调
参考例句:
  • Reports of anorexia and other eating disorders are on the increase. 据报告,厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
  • The announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》
3 subjective mtOwP     
a.主观(上)的,个人的
参考例句:
  • The way they interpreted their past was highly subjective. 他们解释其过去的方式太主观。
  • A literary critic should not be too subjective in his approach. 文学评论家的看法不应太主观。
4 depressed xu8zp9     
adj.沮丧的,抑郁的,不景气的,萧条的
参考例句:
  • When he was depressed,he felt utterly divorced from reality.他心情沮丧时就感到完全脱离了现实。
  • His mother was depressed by the sad news.这个坏消息使他的母亲意志消沉。
5 resonance hBazC     
n.洪亮;共鸣;共振
参考例句:
  • Playing the piano sets up resonance in those glass ornaments.一弹钢琴那些玻璃饰物就会产生共振。
  • The areas under the two resonance envelopes are unequal.两个共振峰下面的面积是不相等的。
6 gene WgKxx     
n.遗传因子,基因
参考例句:
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
7 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句:
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
8 alterations c8302d4e0b3c212bc802c7294057f1cb     
n.改动( alteration的名词复数 );更改;变化;改变
参考例句:
  • Any alterations should be written in neatly to the left side. 改动部分应书写清晰,插在正文的左侧。 来自《简明英汉词典》
  • Gene mutations are alterations in the DNA code. 基因突变是指DNA 密码的改变。 来自《简明英汉词典》
9 psychiatry g0Jze     
n.精神病学,精神病疗法
参考例句:
  • The study appeared in the Amercian science Journal of Psychiatry.这个研究发表在美国精神病学的杂志上。
  • A physician is someone who specializes in psychiatry.精神病专家是专门从事精神病治疗的人。
10 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
11 computing tvBzxs     
n.计算
参考例句:
  • to work in computing 从事信息处理
  • Back in the dark ages of computing, in about 1980, they started a software company. 早在计算机尚未普及的时代(约1980年),他们就创办了软件公司。
12 previously bkzzzC     
adv.以前,先前(地)
参考例句:
  • The bicycle tyre blew out at a previously damaged point.自行车胎在以前损坏过的地方又爆开了。
  • Let me digress for a moment and explain what had happened previously.让我岔开一会儿,解释原先发生了什么。
13 underlying 5fyz8c     
adj.在下面的,含蓄的,潜在的
参考例句:
  • The underlying theme of the novel is very serious.小说隐含的主题是十分严肃的。
  • This word has its underlying meaning.这个单词有它潜在的含义。
14 functional 5hMxa     
adj.为实用而设计的,具备功能的,起作用的
参考例句:
  • The telephone was out of order,but is functional now.电话刚才坏了,但现在可以用了。
  • The furniture is not fancy,just functional.这些家具不是摆着好看的,只是为了实用。
TAG标签: brain depression gene
发表评论
请自觉遵守互联网相关的政策法规,严禁发布色情、暴力、反动的言论。
评价:
表情:
验证码:点击我更换图片