Like snakes, tumour1 cells shed their skin. Cancer is not a static(静态的) disease but during its development the disease accumulates changes to evade2 natural defences adapting to new environmental circumstances, protecting against chemotherapy and radiotherapy and invading neighbouring organs, eventually causing metastasis(转移,新陈代谢) . Until now little was known about the mechanisms4 involved in these changing processes in a tumour. There is a particularly intriguing5 way in which a tumour that initially6 presents a solid state, attached to nearby cells (epithelial), afterwards becomes a semiliquid mass, detached from tissues and more flexible (mesenchymal).
The team led by Manel Esteller, director of the Cancer Epigenetics and Biology Program at the Bellvitge Biomedical Research Institute (IDIBELL), professor of Genetics at the University of Barcelona and ICREA researcher, has identified a mechanism3 that explains this change. Tumours7 "shed their skin" because some molecular8 switches called microRNAs -responsible for maintaining epithelial(上皮的) appearance of cells- turn off. The finding has been published this week in the online version of the international scientific journal Oncogene, Nature group.
"We have discovered that some microRNAs, a group called microRNA-200S, undergoes a chemical inactivation9 and inhibit10 their expression. When these cellular11 appearance drivers are not present, tumour cells change, stretch, stop their inhibition and thus the tumour progresses," explains Dr. Esteller, adding that "the results from research show that this is a very dynamic process."
Change involves from the appearance of the tumour to the onset12 of metastasis, but if we change the environmental circumstances that influence these cells, the process reverses. Dr Esteller compares the process "with a small planet in Darwinian evolution but in an expedited manner."
The study was conducted mainly in breast and colon13 tumours. Besides serving to better understand the disease, the results are important because they predict that external intervention14 is possible in the process. In this sense, drug treatments can reverse the process and move from a highly evolved tumour form to a more primitive15 form, which would be associated with a slower progression of the disease.