肺癌患者EGFR增高表明西妥昔单抗化疗有疗效
文章来源:未知 文章作者:enread 发布时间:2011-07-06 04:59 字体: [ ]  进入论坛
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High epidermal1 growth factor receptor (EGFR表皮生长因子受体) expression was a good predictor of which lung cancer patients would survive longer when cetuximab (Erbitux) was added to first-line chemotherapy, according to research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer (IASLC). "The new analysis of the Phase III FLEX2 study has allowed us to identify which non-small cell lung cancer patients are most likely to benefit from treatment with Erbitux in the first-line setting," said principal investigator3 Dr. Robert Pirker of the Medical University of Vienna in Austria. "By demonstrating that high EGFR expression is the first predictive biomarker for improved overall survival in advanced NSCLC, we have taken a major step towards a more personalized approach in this difficult-to-treat disease."

Based on a new analysis of all FLEX patients (1,121 out of 1,125 FLEX study patients), researchers found that patients with high tumor4 EGFR expression (200 and above on a scale of 0-300) consistently benefited from the addition of cetuximab to chemotherapy(化学疗法) regardless of histology(组织学) . Within this group, overall survival averaged 12 months, compared with 9.6 months for patients receiving chemotherapy alone.

In patients with low EGFR expression, no difference in overall survival was seen between patients receiving chemotherapy plus cetuximab, compared to those receiving chemotherapy alone.



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1 epidermal 5766075fb8cff831ca9f6dcb335ab9bc     
adj. [解][生]表皮的,外皮的
参考例句:
  • Epidermal growth factor is a single-chain peptide with 53 amino-acid residue. 表皮生长因子(epidermal growth factor EGF)是最初从小鼠的下颌下腺提取的一种含有53个氨基酸残基的单链多肽。
  • Telia are dark brown or black, and shine from the intact host epidermal covering. 冬孢子堆呈暗褐色或黑色,覆盖在完整的寄生表皮下显得发亮。
2 flex Cjwxc     
n.皮线,花线;vt.弯曲或伸展
参考例句:
  • We wound off a couple of yards of wire for a new lamp flex.我们解开几码电线作为新的电灯花线。
  • He gave his biceps a flex to impress the ladies.他收缩他的肱二头肌以吸引那些女士们的目光。
3 investigator zRQzo     
n.研究者,调查者,审查者
参考例句:
  • He was a special investigator for the FBI.他是联邦调查局的特别调查员。
  • The investigator was able to deduce the crime and find the criminal.调查者能够推出犯罪过程并锁定罪犯。
4 tumor fKxzm     
n.(肿)瘤,肿块(英)tumour
参考例句:
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
TAG标签: patients cancer lung
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