No matter how you slice it, watermelon has a lot going for it –– sweet, low calorie, high fiber¹, nutrient² rich –– and now, there's more. Evidence from a pilot study（初步研究） led by food scientists at The Florida State University suggests that watermelon can be an effective natural weapon against prehypertension, a precursor³（先驱，前导） to cardiovascular（心血管的） disease. It is the first investigation⁵ of its kind in humans. FSU Assistant Professor Arturo Figueroa and Professor Bahram H. Arjmandi found that when six grams of the amino acid（氨基酸） L-citrulline/L-arginine from watermelon extract was administered daily for six weeks, there was improved arterial function and consequently lowered aortic⁷（大动脉的） blood pressure in all nine of their prehypertensive subjects (four men and five postmenopausal women, ages 51-57).

"We are the first to document improved aortic hemodynamics（血液动力学） in prehypertensive but otherwise healthy middle-aged⁸ men and women receiving therapeutic⁹ doses of watermelon," Figueroa said. "These findings suggest that this 'functional¹⁰ food' has a vasodilatory effect, and one that may prevent prehypertension from progressing to full-blown hypertension, a major risk factor for heart attacks and strokes.

"Given the encouraging evidence generated by this preliminary study, we hope to continue the research and include a much larger group of participants in the next round," he said.

Why watermelon?

"Watermelon is the richest edible¹¹（可食用的） natural source of L-citrulline, which is closely related to L-arginine, the amino acid required for the formation of nitric oxide¹² essential to the regulation of vascular⁴ tone and healthy blood pressure," Figueroa said.

Once in the body, the L-citrulline is converted into L-arginine. Simply consuming L-arginine as a dietary supplement isn't an option for many hypertensive adults, said Figueroa, because it can cause nausea¹³, gastrointestinal tract⁶（胃肠道） discomfort¹⁴, and diarrhea（腹泻，痢疾） .

In contrast, watermelon is well tolerated. Participants in the Florida State pilot study reported no adverse¹⁵ effects. And, in addition to the vascular benefits of citrulline（瓜氨酸） , watermelon provides abundant vitamin A, B6, C, fiber, potassium（钾） and lycopene（番茄红素） , a powerful antioxidant. Watermelon may even help to reduce serum¹⁶ glucose¹⁷ levels, according to Arjmandi.

"Cardiovascular disease (CVD) continues to be the leading cause of death in the United States," Arjmandi said. "Generally, Americans have been more concerned about their blood cholesterol¹⁸ levels and dietary cholesterol intakes¹⁹ rather than their overall cardiovascular health risk factors leading to CVD, such as obesity²⁰ and vascular dysfunction（功能紊乱） characterized by arterial stiffening²¹ and thickness –– issues that functional foods such as watermelon can help to mitigate²²（减轻，缓和） .

"By functional foods," said Arjmandi, "we mean those foods scientifically shown to have health-promoting or disease-preventing properties, above and beyond the other intrinsically（本质地，内在地） healthy nutrients²³ they also supply."

Figueroa said oral L-citrulline supplementation might allow a reduced dosage（剂量，用量） of antihypertensive drugs necessary to control blood pressure.

"Even better, it may prevent the progression from prehypertension to hypertension in the first place," he said.

While watermelon or watermelon extract is the best natural source for L-citrulline, it is also available in the synthetic²⁴ form in pills, which Figueroa used in a previous study of younger, male subjects. That investigation showed that four weeks of L-citrulline slowed or weakened the increase in aortic blood pressure in response to cold exposure. It was an important finding, said Figueroa, since there is a greater occurrence of myocardial infarction（心肌梗塞） associated with hypertension during the cold winter months.

"Individuals with increased blood pressure and arterial stiffness –– especially those who are older and those with chronic²⁵ diseases such as type 2 diabetes²⁶ –– would benefit from L-citrulline in either the synthetic or natural (watermelon) form," Figueroa said. "The optimal²⁷ dose appears to be four to six grams a day."

Approximately 60 percent of U.S. adults are prehypertensive or hypertensive. Prehypertension is characterized by systolic blood pressure readings of 120-139 millimeters of mercury (mm Hg) over diastolic pressure（舒张压） of 80-89 mm Hg. "Systolic" refers to the blood pressure when the heart is contracting. "Diastolic" reflects the blood pressure when the heart is in a period of relaxation²⁸ and expansion.

Findings from Figueroa's latest pilot study at Florida State are described in the American Journal of Hypertension. A copy of the paper ("Effects of Watermelon Supplementation on Aortic Blood Pressure and Wave Reflection in Individuals With Prehypertension: A Pilot Study") can be accessed online.

The paper's lead author, Figueroa holds a medical degree, a doctoral degree in physiological²⁹ sciences, and a master's degree in sports medicine. He has been a faculty³⁰ member（教职工） in the Florida State University Department of Nutrition, Food and Exercise Sciences since 2004. Figueroa's coauthor and colleague Arjmandi serves as chairman of the department, which is a part of Florida State's interdisciplinary（各学科间的） College of Human Sciences. Arjmandi also is the author or coauthor of an extensive body of published research on the health benefits of prunes³¹（干梅子） and other functional foods.