患红斑狼疮的黑人妇女早年易患心血管疾病
文章来源:未知 文章作者:meng 发布时间:2010-08-20 01:49 字体: [ ]  进入论坛
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A recent study by researchers at Penn State College of Medicine found significant racial disparities(不同,不一致) in the age of systemic lupus(狼疮,天狼星) erythematosus(全身性红斑狼疮) (SLE) patients at the time of hospital admission for cardiovascular disease(心血管疾病) (CVD) events and CVD-related death. Black women were youngest to both be admitted with CVD and to have an in-hospital death due to CVD. Results of the study appear in the September issue of Arthritis1 & Rheumatism2, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology(风湿病学) . Lupus is a chronic3 autoimmune disease where the body's own immune system attacks healthy cells and tissues, causing inflammation, extreme fatigue4(疲劳,疲乏) , joint5 pain, and organ damage. According to the Lupus Foundation of American approximately 1.5 million American in the U.S. have some form of lupus, with SLE representing 70% of all cases. In those patients with SLE, cardiovascular disease is a major cause of illness and mortality with recent studies suggesting 36% of all SLE-related deaths are attributed to ischemic(缺血的) heart disease.

Using data from the Health Care Utilization6 Project (HCUP) Nationwide Inpatient Sample (NIS) database, Lisabeth Scalzi, M.D., M.S., and colleagues analyzed7 all adult (18 years of age or older) patient records between 2003 and 2006. After eliminating records without complete demographic information, the research team identified 90,444 hospitalizations for SLE patients and roughly 19 million for subjects without SLE. Of those with SLE, 89% were women, compared with 61% in the non-SLE population. The racial composition of the SLE group was: 55% white, 28% black, 12% Hispanic, 2% Asian, and 3% other.

The team noted8 3,627 admissions for acute CVD among female SLE patients with a mean age of 60.8 years. In female patients without SLE who were admitted with CVD the mean age was 71.3 years. Black women were the youngest to experience a CVD event—53.9 years for those with SLE and 65.8 for those without the disease. "In female SLE patients, we found a 9.6 year difference in age difference at time of hospitalization for CVD between black patients and white patients (mean age-63.5 years)," said Dr. Scalzi.

This is also the first known study to compare age at the time of CVD and CVD-related death in men with SLE to those without the disease. There were 805 male SLE patients who were admitted due to a CVD event with black or Hispanic patients being the youngest. Results indicate that men with SLE were 5.5 years younger than men without SLE at the time of admission for CVD and 11 years younger at the time of in-hospital death due to CVD.

Additionally, research showed there were 218 admissions of women with SLE where in-hospital death was attributed to a CVD event. In this group, black women were also youngest (mean age of 52.8 years) at the time of death compared with other racial groups (mean ages for white-67.1 years; Hispanic-62 years; Asian 63.8 years). Dr. Scalzi noted, "More than half of the black women with SLE who died of CVD were younger than 55 years of age. Most startling(令人吃惊的) was the vast age difference between patients with SLE and their age-matched controls at the time of CVD-related death: black women with SLE were almost 20 years younger than black women without SLE (52.8 versus9 72.6 years of age)."

The authors suggest that many traditional CVD risk factors (smoking, obesity10, high cholesterol胆固醇) are modifiable and active risk factor management should target women with SLE. Of particular concern is identification of young black and Hispanic SLE patients who are of greatest risk. "Studies in ethnically11 diverse lupus populations are warranted to examine the success in addressing risk factor management and barriers that may hamper12(妨碍,束缚) effective management efforts," concluded Dr. Scalzi. "Prescription13 habits, adherence14 to(遵守) prescribed therapy, awareness15 of heart attack warning signs, and appropriate management of acute CVD events should also be examined for any racial disparities."



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1 arthritis XeyyE     
n.关节炎
参考例句:
  • Rheumatoid arthritis has also been linked with the virus.风湿性关节炎也与这种病毒有关。
  • He spent three months in the hospital with acute rheumatic arthritis.他患急性风湿性关节炎,在医院住了三个月。
2 rheumatism hDnyl     
n.风湿病
参考例句:
  • The damp weather plays the very devil with my rheumatism.潮湿的天气加重了我的风湿病。
  • The hot weather gave the old man a truce from rheumatism.热天使这位老人暂时免受风湿病之苦。
3 chronic BO9zl     
adj.(疾病)长期未愈的,慢性的;极坏的
参考例句:
  • Famine differs from chronic malnutrition.饥荒不同于慢性营养不良。
  • Chronic poisoning may lead to death from inanition.慢性中毒也可能由虚弱导致死亡。
4 fatigue PhVzV     
n.疲劳,劳累
参考例句:
  • The old lady can't bear the fatigue of a long journey.这位老妇人不能忍受长途旅行的疲劳。
  • I have got over my weakness and fatigue.我已从虚弱和疲劳中恢复过来了。
5 joint m3lx4     
adj.联合的,共同的;n.关节,接合处;v.连接,贴合
参考例句:
  • I had a bad fall,which put my shoulder out of joint.我重重地摔了一跤,肩膀脫臼了。
  • We wrote a letter in joint names.我们联名写了封信。
6 utilization Of0zMC     
n.利用,效用
参考例句:
  • Computer has found an increasingly wide utilization in all fields.电子计算机已越来越广泛地在各个领域得到应用。
  • Modern forms of agricultural utilization,have completely refuted this assumption.现代农业利用形式,完全驳倒了这种想象。
7 analyzed 483f1acae53789fbee273a644fdcda80     
v.分析( analyze的过去式和过去分词 );分解;解释;对…进行心理分析
参考例句:
  • The doctors analyzed the blood sample for anemia. 医生们分析了贫血的血样。 来自《简明英汉词典》
  • The young man did not analyze the process of his captivation and enrapturement, for love to him was a mystery and could not be analyzed. 这年轻人没有分析自己蛊惑著迷的过程,因为对他来说,爱是个不可分析的迷。 来自《简明英汉词典》
8 noted 5n4zXc     
adj.著名的,知名的
参考例句:
  • The local hotel is noted for its good table.当地的那家酒店以餐食精美而著称。
  • Jim is noted for arriving late for work.吉姆上班迟到出了名。
9 versus wi7wU     
prep.以…为对手,对;与…相比之下
参考例句:
  • The big match tonight is England versus Spain.今晚的大赛是英格兰对西班牙。
  • The most exciting game was Harvard versus Yale.最富紧张刺激的球赛是哈佛队对耶鲁队。
10 obesity Dv1ya     
n.肥胖,肥大
参考例句:
  • One effect of overeating may be obesity.吃得过多能导致肥胖。
  • Sugar and fat can more easily lead to obesity than some other foods.糖和脂肪比其他食物更容易导致肥胖。
11 ethnically 5cad57d992c22d4f4a6ad0169c5276d2     
adv.人种上,民族上
参考例句:
  • Ethnically, the Yuan Empire comprised most of modern China's ethnic groups. 元朝的民族成分包括现今中国绝大多数民族。 来自汉英非文学 - 白皮书
  • Russia is ethnically relatively homogeneous. 俄罗斯是个民族成分相对单一的国家。 来自辞典例句
12 hamper oyGyk     
vt.妨碍,束缚,限制;n.(有盖的)大篮子
参考例句:
  • There are some apples in a picnic hamper.在野餐用的大篮子里有许多苹果。
  • The emergence of such problems seriously hamper the development of enterprises.这些问题的出现严重阻碍了企业的发展。
13 prescription u1vzA     
n.处方,开药;指示,规定
参考例句:
  • The physician made a prescription against sea- sickness for him.医生给他开了个治晕船的药方。
  • The drug is available on prescription only.这种药只能凭处方购买。
14 adherence KyjzT     
n.信奉,依附,坚持,固着
参考例句:
  • He was well known for his adherence to the rules.他因遵循这些规定而出名。
  • The teacher demanded adherence to the rules.老师要求学生们遵守纪律。
15 awareness 4yWzdW     
n.意识,觉悟,懂事,明智
参考例句:
  • There is a general awareness that smoking is harmful.人们普遍认识到吸烟有害健康。
  • Environmental awareness has increased over the years.这些年来人们的环境意识增强了。
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