肺动脉高压丛状病变发病机理
文章来源:未知 文章作者:meng 发布时间:2010-05-20 01:38 字体: [ ]  进入论坛
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A new preclinical(临床前的) model of pulmonary arterial hypertension (PAH肺动脉高压) may lead to improved research and ultimately better therapies for this life-threatening problem, according to its developers, researchers at the University of South Alabama. The researchers modified a recently developed rat model of severe PAH and found that the model can mimic1 the plexiform(丛状的) lesion(损害,机能障碍) , the signature lesion of PAH.

Their results will be presented at the ATS 2010 International Conference in New Orleans.

"This study provides convincing evidence for the first time that the plexiform lesion develops in an experimental rat model of severe PAH," said Kohtaro Abe, M.D., Ph.D., lead author of the study. "To date, no small animal model of pulmonary arterial hypertension exists that rigorously mimics2 the plexiform lesion, the hallmark lesion of severe PAH, found in human patients."

PAH is characterized by high blood pressure in the lung that leads to pressure overload3 and failure of the right side of the heart. Approximately 2,000 - 5,000 patients are newly diagnosed with PAH each year in the United States and, despite recent advances in the understanding and treatment of this disorder4, PAH is still a progressive and fatal illness. One major barricade5 to better therapies is the lack of appropriate animal models. Although a number of rodent6(啮齿类的) models of PAH are currently used, none of them develops the classic plexiform lesion.

"An animal model that closely mimics human PAH is needed for better understanding and treatment of this devastating7 pulmonary vascular8 disorder," said Dr. Abe.

Because plexiform lesions are found only in late and advanced stages of PAH patients, Dr. Abe and colleagues hypothesized that the lesion would also develop in later stages of experimental models of severe PAH.

"One report of a patient with PAH found it took five years to develop plexiform lesions after diagnosis9 of severe PAH. Assuming that the natural history of chronic10 disorders11 is proportional to the life span(寿命) of the species, five years in humans translates into about 10 weeks in rats," explained Dr. Abe.

To determine whether they would be able to induce plexiform lesions in rats, the researchers injected rats with a vascular(血管的) endothelial(内皮的) growth factor receptor blocker (SUGEN5416) and kept them in a hypoxic(低氧的) chamber12 for three weeks before returning them to a normalized oxygen level for an additional 10-11 weeks.

They found that all of the rats developed the plexiform lesions. "We found in these late stages of severe PAH, the rats developed plexiform and other complex lesions indistinguishable from those observed in human patients," said Dr. Abe. "In addition to the plexiform lesion, this model also closely mimics the high pulmonary blood pressure and decreased heart function of human PAH."

Dr. Abe and colleagues believe this model will reveal more detailed13 cellular14 and molecular15 mechanisms16 of severe PAH.

"Next, we will investigate how the plexiform lesion forms and determine whether it is the cause or the effect of the PAH in this model," concluded Dr. Abe. "This model allows rigorous(严格的,严酷的) preclinical drug testing to discover more effective treatments for severe PAH."



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1 mimic PD2xc     
v.模仿,戏弄;n.模仿他人言行的人
参考例句:
  • A parrot can mimic a person's voice.鹦鹉能学人的声音。
  • He used to mimic speech peculiarities of another.他过去总是模仿别人讲话的特点。
2 mimics f8207fb5fa948f536c5186311e3e641d     
n.模仿名人言行的娱乐演员,滑稽剧演员( mimic的名词复数 );善于模仿的人或物v.(尤指为了逗乐而)模仿( mimic的第三人称单数 );酷似
参考例句:
  • Methods:Models were generate by CT scan,Mimics software and Abaqus software. 方法:采用CT扫描,Mimics软件和Abaqus软件的CAD进行三维有限元模型的创建。 来自互联网
  • Relaxing the mind and body mimics the effect that some blood-pressure pills would have. 放松身心会产生某些降压药才能产生的效果。 来自辞典例句
3 overload RmHz40     
vt.使超载;n.超载
参考例句:
  • Don't overload the boat or it will sink.别超载,否则船会沉。
  • Large meals overload the digestive system.吃得太饱会加重消化系统的负担。
4 disorder Et1x4     
n.紊乱,混乱;骚动,骚乱;疾病,失调
参考例句:
  • When returning back,he discovered the room to be in disorder.回家后,他发现屋子里乱七八糟。
  • It contained a vast number of letters in great disorder.里面七零八落地装着许多信件。
5 barricade NufzI     
n.路障,栅栏,障碍;vt.设路障挡住
参考例句:
  • The soldiers make a barricade across the road.士兵在路上设路障。
  • It is difficult to break through a steel barricade.冲破钢铁障碍很难。
6 rodent DsNyh     
n.啮齿动物;adj.啮齿目的
参考例句:
  • When there is a full moon,this nocturnal rodent is careful to stay in its burrow.月圆之夜,这种夜间活动的啮齿类动物会小心地呆在地洞里不出来。
  • This small rodent can scoop out a long,narrow tunnel in a very short time.这种小啮齿动物能在很短的时间里挖出一条又长又窄的地道来。
7 devastating muOzlG     
adj.毁灭性的,令人震惊的,强有力的
参考例句:
  • It is the most devastating storm in 20 years.这是20年来破坏性最大的风暴。
  • Affairs do have a devastating effect on marriages.婚外情确实会对婚姻造成毁灭性的影响。
8 vascular cidw6     
adj.血管的,脉管的
参考例句:
  • The mechanism of this anomalous vascular response is unknown.此种不规则的血管反应的机制尚不清楚。
  • The vascular changes interfere with diffusion of nutrients from plasma into adjacent perivascular tissue and cells.这些血管变化干扰了营养物质从血浆中向血管周围邻接的组织和细胞扩散。
9 diagnosis GvPxC     
n.诊断,诊断结果,调查分析,判断
参考例句:
  • His symptoms gave no obvious pointer to a possible diagnosis.他的症状无法作出明确的诊断。
  • The engineer made a complete diagnosis of the bridge's collapse.工程师对桥的倒塌做一次彻底的调查分析。
10 chronic BO9zl     
adj.(疾病)长期未愈的,慢性的;极坏的
参考例句:
  • Famine differs from chronic malnutrition.饥荒不同于慢性营养不良。
  • Chronic poisoning may lead to death from inanition.慢性中毒也可能由虚弱导致死亡。
11 disorders 6e49dcafe3638183c823d3aa5b12b010     
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调
参考例句:
  • Reports of anorexia and other eating disorders are on the increase. 据报告,厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
  • The announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》
12 chamber wnky9     
n.房间,寝室;会议厅;议院;会所
参考例句:
  • For many,the dentist's surgery remains a torture chamber.对许多人来说,牙医的治疗室一直是间受刑室。
  • The chamber was ablaze with light.会议厅里灯火辉煌。
13 detailed xuNzms     
adj.详细的,详尽的,极注意细节的,完全的
参考例句:
  • He had made a detailed study of the terrain.他对地形作了缜密的研究。
  • A detailed list of our publications is available on request.我们的出版物有一份详细的目录备索。
14 cellular aU1yo     
adj.移动的;细胞的,由细胞组成的
参考例句:
  • She has a cellular telephone in her car.她的汽车里有一部无线通讯电话机。
  • Many people use cellular materials as sensitive elements in hygrometers.很多人用蜂窝状的材料作为测量温度的传感元件。
15 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
16 mechanisms d0db71d70348ef1c49f05f59097917b8     
n.机械( mechanism的名词复数 );机械装置;[生物学] 机制;机械作用
参考例句:
  • The research will provide direct insight into molecular mechanisms. 这项研究将使人能够直接地了解分子的机理。 来自《简明英汉词典》
  • He explained how the two mechanisms worked. 他解释这两台机械装置是如何工作的。 来自《简明英汉词典》
TAG标签: heart lesion pulmonary
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