纳米微粒 对付癌细胞的“聪明”杀手
文章来源:未知 文章作者:meng 发布时间:2010-03-09 00:33 字体: [ ]  进入论坛
(单词翻译:双击或拖选)

Another weapon in the arsenal1(兵工厂,军械库) against cancer: Nanoparticles that identify, target and kill specific cancer cells while leaving healthy cells alone. Led by Carl Batt, the Liberty Hyde Bailey Professor of Food Science, the researchers synthesized(综合,合成) nanoparticles – shaped something like a dumbbell(哑铃) – made of gold sandwiched between two pieces of iron oxide2(氧化铁) . They then attached antibodies, which target a molecule3 found only in colorectal(结肠直肠的) cancer cells, to the particles. Once bound, the nanoparticles are engulfed4(吞没,吞食) by the cancer cells.

To kill the cells, the researchers use a near-infrared laser, which is a wavelength5 that doesn't harm normal tissue at the levels used, but the radiation is absorbed by the gold in the nanoparticles. This causes the cancer cells to heat up and die.

"This is a so-called 'smart' therapy," Batt said. "To be a smart therapy, it should be targeted, and it should have some ability to be activated6 only when it's there and then kills just the cancer cells."

The goal, said lead author and biomedical graduate student Dickson Kirui, is to improve the technology and make it suitable for testing in a human clinical trial. The researchers are now working on a similar experiment targeting prostate cancer(前列腺癌) cells.

"If, down the line, you could clinically just target the cancer cells, you could then spare the health surrounding cells from being harmed – that is the critical thing," Kirui said.

Gold has potential as a material key to fighting cancer in future smart therapies. It is biocompatible(生物可相容的,不会引起排斥的) , inert7(惰性的,迟缓的) and relatively8 easy to tweak chemically. By changing the size and shape of the gold particle, Kirui and colleagues can tune9 them to respond to different wavelengths10 of energy.

Once taken up by the researchers' gold particles, the cancer cells are destroyed by heat – just a few degrees above normal body temperature – while the surrounding tissue is left unharmed. Such a low-power laser does not have any effect on surrounding cells because that particular wavelength does not heat up cells if they are not loaded up with nanoparticles, the researchers explained.

Using iron oxide – which is basically rust11(生锈) – as the other parts of the particles might one day allow scientists to also track the progress of cancer treatments using magnetic resonance12 imaging(磁共振成像) , Kirui said, by taking advantage of the particles' magnetic properties.



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1 arsenal qNPyF     
n.兵工厂,军械库
参考例句:
  • Even the workers at the arsenal have got a secret organization.兵工厂工人暗中也有组织。
  • We must be the great arsenal of democracy.我们必须成为民主的大军火库。
2 oxide K4dz8     
n.氧化物
参考例句:
  • Oxide is usually seen in our daily life.在我们的日常生活中氧化物很常见。
  • How can you get rid of this oxide coating?你们该怎样除去这些氧化皮?
3 molecule Y6Tzn     
n.分子,克分子
参考例句:
  • A molecule of water is made up of two atoms of hygrogen and one atom of oxygen.一个水分子是由P妈?f婘??妈?成的。
  • This gives us the structural formula of the molecule.这种方式给出了分子的结构式。
4 engulfed 52ce6eb2bc4825e9ce4b243448ffecb3     
v.吞没,包住( engulf的过去式和过去分词 )
参考例句:
  • He was engulfed by a crowd of reporters. 他被一群记者团团围住。
  • The little boat was engulfed by the waves. 小船被波浪吞没了。 来自《简明英汉词典》
5 wavelength 8gHwn     
n.波长
参考例句:
  • The authorities were unable to jam this wavelength.当局无法干扰这一波长。
  • Radio One has broadcast on this wavelength for years.广播1台已经用这个波长广播多年了。
6 activated c3905c37f4127686d512a7665206852e     
adj. 激活的 动词activate的过去式和过去分词
参考例句:
  • The canister is filled with activated charcoal.蒸气回收罐中充满了活性炭。
7 inert JbXzh     
adj.无活动能力的,惰性的;迟钝的
参考例句:
  • Inert gas studies are providing valuable information about other planets,too.对惰性气体的研究,也提供了有关其它行星的有价值的资料。
  • Elemental nitrogen is a very unreactive and inert material.元素氮是一个十分不活跃的惰性物质。
8 relatively bkqzS3     
adv.比较...地,相对地
参考例句:
  • The rabbit is a relatively recent introduction in Australia.兔子是相对较新引入澳大利亚的物种。
  • The operation was relatively painless.手术相对来说不痛。
9 tune NmnwW     
n.调子;和谐,协调;v.调音,调节,调整
参考例句:
  • He'd written a tune,and played it to us on the piano.他写了一段曲子,并在钢琴上弹给我们听。
  • The boy beat out a tune on a tin can.那男孩在易拉罐上敲出一首曲子。
10 wavelengths 55c7c1db2849f4af018e7824d42c3ff2     
n.波长( wavelength的名词复数 );具有相同的/不同的思路;合拍;不合拍
参考例句:
  • I find him difficult to talk to—we're on completely different wavelengths. 我没法和他谈话,因为我们俩完全不对路。 来自《简明英汉词典》
  • Sunlight consists of different wavelengths of radiation. 阳光由几种不同波长的射线组成。 来自辞典例句
11 rust XYIxu     
n.锈;v.生锈;(脑子)衰退
参考例句:
  • She scraped the rust off the kitchen knife.她擦掉了菜刀上的锈。
  • The rain will rust the iron roof.雨水会使铁皮屋顶生锈。
12 resonance hBazC     
n.洪亮;共鸣;共振
参考例句:
  • Playing the piano sets up resonance in those glass ornaments.一弹钢琴那些玻璃饰物就会产生共振。
  • The areas under the two resonance envelopes are unequal.两个共振峰下面的面积是不相等的。
TAG标签: cancer gold iron nano
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