丹麦科学家在预防遗传性疟疾的研究中取得重大突破
文章来源:未知 文章作者:meng 发布时间:2010-02-05 00:30 字体: [ ]  进入论坛
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Researchers at the University of Copenhagen have become the first in the world to synthesize合成,综合 the entire protein that is responsible for life-threatening malaria疟疾,瘴气 in pregnant women and their unborn children. The protein known as VAR2CSA enables malaria1 parasites3寄生虫 to accumulate in the placenta胎盘 and can therefore potentially be used as the main component4 in a vaccine5 to trigger antibodies抗体 that protect pregnant women against malaria. The research team is now planning to test the efficacy of the protein-based vaccine on humans. The hope is that within 10 years all African girls could be vaccinated6 against maternal7 malaria, thereby8 preventing more than 200,000 deaths a year. Each year, 25 million pregnant women in sub-Saharan Africa run the risk of contracting malaria. Women who have become infected with malaria parasites during their first pregnancy9 are at considerable risk of severe anaemia贫血,脸色苍白 and significant impairment损伤,损害 of foetal胎儿的 growth. The malaria parasites accumulate in the placenta, resulting in children being born prematurely10过早地 and underweight. These women are also at greater risk of dying during pregnancy and childbirth. Maternal malaria is the cause of death of between 100,000 and 200,000 newborn babies and 10,000 women each year.

"The malaria research group discovered the protein VAR2CSA, which is responsible for malaria parasite2 binding11 in the placenta, in 2003," says Associate Professor Ali Salanti from the centre. "The aim is to produce a vaccine based on VAR2CSA which elicits13抽出,引起 antibodies that stop the parasite from binding to the placenta. The challenge for us has been to produce the entire protein in the laboratory, as it is very large and so technically14 complex. Now that we've managed to do this, we're a big step closer to developing a human vaccine, as we can already test it as a vaccine in animals."

"In collaboration15 with合作,勾结 scientists at The Tanzanian National Institute for Medical Research, we've tested the antibodies that were produced in the laboratory on a number of malaria parasites from pregnant women in Tanzania," says Professor Thor Theander from the centre. "These antibodies seem to be effective at preventing the parasite from accumulating in the placental tissue. The next step is to investigate whether we can elicit12 the same antibodies and so protect against the disease by vaccinating16 humans. Then the vaccine will be a reality."



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1 malaria B2xyb     
n.疟疾
参考例句:
  • He had frequent attacks of malaria.他常患疟疾。
  • Malaria is a kind of serious malady.疟疾是一种严重的疾病。
2 parasite U4lzN     
n.寄生虫;寄生菌;食客
参考例句:
  • The lazy man was a parasite on his family.那懒汉是家里的寄生虫。
  • I don't want to be a parasite.I must earn my own way in life.我不想做寄生虫,我要自己养活自己。
3 parasites a8076647ef34cfbbf9d3cb418df78a08     
寄生物( parasite的名词复数 ); 靠他人为生的人; 诸虫
参考例句:
  • These symptoms may be referable to virus infection rather than parasites. 这些症状也许是由病毒感染引起的,而与寄生虫无关。
  • Kangaroos harbor a vast range of parasites. 袋鼠身上有各种各样的寄生虫。
4 component epSzv     
n.组成部分,成分,元件;adj.组成的,合成的
参考例句:
  • Each component is carefully checked before assembly.每个零件在装配前都经过仔细检查。
  • Blade and handle are the component parts of a knife.刀身和刀柄是一把刀的组成部分。
5 vaccine Ki1wv     
n.牛痘苗,疫苗;adj.牛痘的,疫苗的
参考例句:
  • The polio vaccine has saved millions of lives.脊髓灰质炎疫苗挽救了数以百万计的生命。
  • She takes a vaccine against influenza every fall.她每年秋季接种流感疫苗。
6 vaccinated 8f16717462e6e6db3389d0f736409983     
[医]已接种的,种痘的,接种过疫菌的
参考例句:
  • I was vaccinated against tetanus. 我接种了破伤风疫苗。
  • Were you vaccinated against smallpox as a child? 你小时候打过天花疫苗吗?
7 maternal 57Azi     
adj.母亲的,母亲般的,母系的,母方的
参考例句:
  • He is my maternal uncle.他是我舅舅。
  • The sight of the hopeless little boy aroused her maternal instincts.那个绝望的小男孩的模样唤起了她的母性。
8 thereby Sokwv     
adv.因此,从而
参考例句:
  • I have never been to that city,,ereby I don't know much about it.我从未去过那座城市,因此对它不怎么熟悉。
  • He became a British citizen,thereby gaining the right to vote.他成了英国公民,因而得到了投票权。
9 pregnancy lPwxP     
n.怀孕,怀孕期
参考例句:
  • Early pregnancy is often accompanied by nausea.怀孕早期常有恶心的现象。
  • Smoking during pregnancy increases the risk of miscarriage.怀孕期吸烟会增加流产的危险。
10 prematurely nlMzW4     
adv.过早地,贸然地
参考例句:
  • She was born prematurely with poorly developed lungs. 她早产,肺部未发育健全。 来自《简明英汉词典》
  • His hair was prematurely white, but his busy eyebrows were still jet-black. 他的头发已经白了,不过两道浓眉还是乌黑乌黑的。 来自辞典例句
11 binding 2yEzWb     
有约束力的,有效的,应遵守的
参考例句:
  • The contract was not signed and has no binding force. 合同没有签署因而没有约束力。
  • Both sides have agreed that the arbitration will be binding. 双方都赞同仲裁具有约束力。
12 elicit R8ByG     
v.引出,抽出,引起
参考例句:
  • It was designed to elicit the best thinking within the government. 机构的设置是为了在政府内部集思广益。
  • Don't try to elicit business secrets from me. I won't tell you anything. 你休想从我这里套问出我们的商业机密, 我什么都不会告诉你的。
13 elicits cee4cb809d0a00118197f3ba47d4b570     
引出,探出( elicit的第三人称单数 )
参考例句:
  • You might find that a sympathetic approach elicits kinder and gentler behavior. 你或许会发现用同情的方法,可引出更友善及更温和的行为。
  • It presents information, shares ideas and elicits emotions. 它展示信息、流思想和抒发情感。
14 technically wqYwV     
adv.专门地,技术上地
参考例句:
  • Technically it is the most advanced equipment ever.从技术上说,这是最先进的设备。
  • The tomato is technically a fruit,although it is eaten as a vegetable.严格地说,西红柿是一种水果,尽管它是当作蔬菜吃的。
15 collaboration bW7yD     
n.合作,协作;勾结
参考例句:
  • The two companies are working in close collaboration each other.这两家公司密切合作。
  • He was shot for collaboration with the enemy.他因通敌而被枪毙了。
16 vaccinating 3c0d2084d9b99d5ef019f89c134247c7     
给…接种疫苗( vaccinate的现在分词 ); 注射疫苗,接种疫苗
参考例句:
  • At first blush, vaccinating the wolves against rabies seems a simple solution. 乍一看来,为狼群注射防狂犬病疫苗是一种简单的办法。
  • Also vaccinating children against misers (measles) has saved many lives. 还有,给儿童进行疫苗接种防止麻疹也挽救了许多生命。
TAG标签: malaria protein placenta
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