Elderly skin 'raises cancer risk' 老年人患皮肤癌几率增大
文章来源:未知 文章作者:meng 发布时间:2009-09-01 06:19 字体: [ ]  进入论坛
(单词翻译:双击或拖选)

Older people are more at risk of skin cancer and infection because their skin is unable to mobilise the immune system to defend itself, UK research suggests.

英国一项调查显示,年老的人患皮肤癌和传染病的几率更高,因为他们的皮肤不能有效地调动免疫系统以自卫。

Skin is more <a href=prone1 to infection and cancer with age" width="226" border="0" src="/upimg/090901/4_063557_1.jpg" />
Skin is more prone to infection and cancer with age

It contradicts(反驳,矛盾) previous thinking that defects in a type of immune cell called a T cell were responsible for waning2 immunity3 with age.

In fact, it is the inability(无能,为力) of the skin to attract T cells to where they are needed that seems to be at fault.

The findings are published in the Journal of Experimental Medicine.

Study leader, Professor Arne Akbar from University College London, said reduced immunity in older people is well known, but why and how it happens is not.

A number of volunteers - one group of 40-year-olds and one group aged4 over 70 - were injected with an antigen(抗原) to stimulate5 an immune response from T cells.

As expected, the immune response in the older group was much less than that in the younger volunteers.

But when the researchers looked at the T cells there was nothing wrong with them.

What had declined in the older group was the ability of the skin to attract T cells - effectively the signals to direct them to the right place were missing.

Reversible

Further experiments with skin samples in a test tube showed that the skin was still able to send the appropriate signals when pushed, suggesting the problem is reversible(可逆的).

"At the outset(起先) we thought it would be the cells responsible for combating infections that might be at fault, but the surprising thing was the T cells were fine but they couldn't get into the skin - the signals were missing," Mr Akbar said.

He said it raised the possibility of ways to boost the immune system in older people to give them a better chance of fighting infection and reducing the risk of skin cancer.

"The question that it raises is what survival advantage there is to this, is there a negative reason for having too much immunity in the skin when you get older?

"Going in to intervene(插入,调停) may have consequences that we don't realise and that's where we need to do more research."

He added that the same immune problems may be apparent(明显的,表面上的) in other tissues in the body.

Steve Visscher, deputy executive at the Biotechnology and Biological Sciences Research Council, which funded the research, said knowing more about the ageing process was vital as people increasingly live longer.

"The more knowledge we have about healthy ageing, the better we get at preventing, managing and treating diseases that are simply a factor of an ageing body."



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1 prone 50bzu     
adj.(to)易于…的,很可能…的;俯卧的
参考例句:
  • Some people are prone to jump to hasty conclusions.有些人往往作出轻率的结论。
  • He is prone to lose his temper when people disagree with him.人家一不同意他的意见,他就发脾气。
2 waning waning     
adj.(月亮)渐亏的,逐渐减弱或变小的n.月亏v.衰落( wane的现在分词 );(月)亏;变小;变暗淡
参考例句:
  • Her enthusiasm for the whole idea was waning rapidly. 她对整个想法的热情迅速冷淡了下来。
  • The day is waning and the road is ending. 日暮途穷。 来自《现代汉英综合大词典》
3 immunity dygyQ     
n.优惠;免除;豁免,豁免权
参考例句:
  • The law gives public schools immunity from taxation.法律免除公立学校的纳税义务。
  • He claims diplomatic immunity to avoid being arrested.他要求外交豁免以便避免被捕。
4 aged 6zWzdI     
adj.年老的,陈年的
参考例句:
  • He had put on weight and aged a little.他胖了,也老点了。
  • He is aged,but his memory is still good.他已年老,然而记忆力还好。
5 stimulate wuSwL     
vt.刺激,使兴奋;激励,使…振奋
参考例句:
  • Your encouragement will stimulate me to further efforts.你的鼓励会激发我进一步努力。
  • Success will stimulate the people for fresh efforts.成功能鼓舞人们去作新的努力。
TAG标签: risk cancer skin immunse
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