After decades of laboring¹ under other theories that never seemed to add up, a team led by biologist Rama Singh has concluded that what causes menopause（更年期） in women is men. Singh, an evolutionary² geneticist, backed by computer models developed by colleagues Jonathan Stone and Richard Morton, has determined⁴ that menopause is actually an unintended outcome of natural selection -- the result of its effects having become relaxed in older women.

 

Over time, human males have shown a preference for younger women in selecting mates, stacking the Darwinian deck against continued fertility in older women, the researchers have found.

 

"In a sense it is like aging, but it is different because it is an all-or-nothing process that has been accelerated because of preferential（优先的） mating," says Singh, a professor in McMaster's Department of Biology whose research specialties⁶ include the evolution of human diversity.

 

Stone is an associate professor in the Department of Biology and associate director of McMaster's Origins Institute, whose themes include the origins of humanity, while Morton is a professor emeritus⁷ in Biology.

 

While conventional thinking has held that menopause prevents older women from continuing to reproduce, in fact, the researchers' new theory says it is the lack of reproduction that has given rise to menopause.

 

Their work appears in the online, open-access journal PLOS Computational Biology.

 

Menopause is believed to be unique to humans, but no one had yet been able to offer a satisfactory explanation for why it occurs, Singh says.

 

The prevailing⁸ "grandmother theory" holds that women have evolved to become infertile⁹ after a certain age to allow them to assist with rearing grandchildren, thus improving the survival of kin⁵. Singh says that does not add up from an evolutionary perspective.

 

"How do you evolve infertility¹⁰? It is contrary to the whole notion of natural selection. Natural selection selects for fertility, for reproduction -- not for stopping it," he says.

 

The new theory holds that, over time, competition among men of all ages for younger mates has left older females with much less chance of reproducing. The forces of natural selection, Singh says, are concerned only with the survival of the species through individual fitness, so they protect fertility in women while they are most likely to reproduce.

 

After that period, natural selection ceases to quell¹¹ the genetic³ mutations that ultimately bring on menopause, leaving women not only infertile, but also vulnerable to a host of health problems.

 

"This theory says that natural selection doesn't have to do anything," Singh says. "If women were reproducing all along, and there were no preference against older women, women would be reproducing like men are for their whole lives."

 

The development of menopause, then, was not a change that improved the survival of the species, but one that merely recognized that fertility did not serve any ongoing¹² purpose beyond a certain age.

 

For the vast majority of other animals, fertility continues until death, Singh explains, but women continue to live past their fertility because men remain fertile throughout their lives, and longevity¹³ is not inherited by gender¹⁴.

 

Singh points out that if women had historically been the ones to select younger mates, the situation would have been reversed, with men losing fertility.

 

The consequence of menopause, however, is not only lost fertility for women, but an increased risk of illness and death that arises with hormonal¹⁵ changes that occur with menopause. Singh says a benefit of the new research could be to suggest that if menopause developed over time, that ultimately it could also be reversed.

点击收听单词发音