5种能导致冠状动脉疾病的基因被发现
文章来源:未知 文章作者:enread 发布时间:2011-09-23 03:54 字体: [ ]  进入论坛
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An international consortium of scientists reports the discovery of five new genes1 that affect the risk of developing coronary artery2 disease (CAD冠状动脉疾病) and heart attacks in a study to be published in the open-access journal PLoS Genetics on September 22nd. Coronary artery disease is the most common cause of premature4 death and disability in the world and has a strong but incompletely characterised genetic3 contribution. The identification of the roles of various genes in the onset5 of heart disease could help in the development of new treatments and improve prediction of CAD. The study also demonstrated that some associations between genes and CAD, suggested by other, smaller studies, are spurious, according to Dr Adam Butterworth, who co-ordinated the analysis.

The consortium examined 49,094 genetic variants6 in ~2,100 genes of cardiovascular relevance7 in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent, and 4,394 cases and 4,259 controls of South Asian origin) and replicated8 their principal findings in an additional 17,121 CAD cases and 40,473 controls.

"This is one of the first genetic studies of CAD to include a significant proportion of subjects of South Asian origin, an ethnic9 group that has a higher risk of CAD," says Professor John Danesh, co-principal investigator10. "Our study shows that many of the genes that affect risk of CAD do so similarly in European Caucasians(白种人) as in South Asians."

The study adds to the growing list of genes, now over 30, that affect risk of CAD and heart attacks. Co-principal investigator Professor Nilesh Samani (British Heart Foundation Professor of Cardiology University of Leicester, UK) says: "The findings provide new insights into and understanding of the causal biological pathways that cause heart disease, and particularly highlight the role of lipids and inflammation."

"Although the effects of the new genetic variants that we have identified are individually small, in the order of 5-10% per copy, new treatments that are developed on the basis of the findings could have a much broader effect, as we have learnt, for example, with statins," adds Professor Hugh Watkins (British Heart Foundation Professor of Cardiovascular Medicine, University of Oxford), also a co-principal investigator.



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1 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句:
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
2 artery 5ekyE     
n.干线,要道;动脉
参考例句:
  • We couldn't feel the changes in the blood pressure within the artery.我们无法感觉到动脉血管内血压的变化。
  • The aorta is the largest artery in the body.主动脉是人体中的最大动脉。
3 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
4 premature FPfxV     
adj.比预期时间早的;不成熟的,仓促的
参考例句:
  • It is yet premature to predict the possible outcome of the dialogue.预言这次对话可能有什么结果为时尚早。
  • The premature baby is doing well.那个早产的婴儿很健康。
5 onset bICxF     
n.进攻,袭击,开始,突然开始
参考例句:
  • The drug must be taken from the onset of the infection.这种药必须在感染的最初期就开始服用。
  • Our troops withstood the onset of the enemy.我们的部队抵挡住了敌人的进攻。
6 variants 796e0e5ff8114b13b2e23cde9d3c6904     
n.变体( variant的名词复数 );变种;变型;(词等的)变体
参考例句:
  • Those variants will be preserved in the'struggle for existence". 这些变异将在“生存竞争”中被保留下来。 来自辞典例句
  • Like organisms, viruses have variants, generally called strains. 与其他生物一样,病毒也有变种,一般称之为株系。 来自辞典例句
7 relevance gVAxg     
n.中肯,适当,关联,相关性
参考例句:
  • Politicians' private lives have no relevance to their public roles.政治家的私生活与他们的公众角色不相关。
  • Her ideas have lost all relevance to the modern world.她的想法与现代社会完全脱节。
8 replicated 08069c56938bbf6ddcc01ee2fd848af5     
复制( replicate的过去式和过去分词 ); 重复; 再造; 再生
参考例句:
  • Later outplant the seedlings in a replicated permanent test plantation. 以后苗木出圃栽植成重复的永久性试验林。
  • The phage has replicated and the donor cells have lysed. 噬菌体已复制和给体细胞已发生裂解。
9 ethnic jiAz3     
adj.人种的,种族的,异教徒的
参考例句:
  • This music would sound more ethnic if you played it in steel drums.如果你用钢鼓演奏,这首乐曲将更具民族特色。
  • The plan is likely only to aggravate ethnic frictions.这一方案很有可能只会加剧种族冲突。
10 investigator zRQzo     
n.研究者,调查者,审查者
参考例句:
  • He was a special investigator for the FBI.他是联邦调查局的特别调查员。
  • The investigator was able to deduce the crime and find the criminal.调查者能够推出犯罪过程并锁定罪犯。
TAG标签: heart disease genes
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