Scientists at the University of East Anglia (UEA) have discovered a rogue¹（凶猛的） gene² which – if blocked by the right drugs – could stop cancer in its tracks. Published today by the journal Oncogene, the discovery is a breakthrough in our understanding of how cancer spreads. It is hoped the research will lead to new drugs that halt the critical late stage of the disease when cancer cells spread to other parts of the body.

The culprit（犯人，罪犯） gene – known as WWP2 - is an enzymic³ bonding agent found inside cancer cells. It attacks and breaks down a natural inhibitor in the body which normally prevents cancer cells spreading. The UEA team found that by blocking WWP2, levels of the natural inhibitor are boosted and the cancer cells remain dormant⁴（休眠的，静止的） . If a drug was developed that deactivated⁵ WWP2, conventional therapies and surgery could be used on primary tumours⁶, with no risk of the disease taking hold eleswhere.

Lead author Andrew Chantry, of UEA's School of Biological Sciences, said the discovery could lead to the development of a new generation of drugs within the next decade that could be used to stop the aggressive spread of most forms of the disease, including breast, brain, colon⁷ and skin cancer.

"The late-stages of cancer involve a process known as metastasis（新陈代谢） - a critical phase in the progression of the disease that cannot currently be treated or prevented," said Dr Chantry.

"The challenge now is to identify a potent⁸ drug that will get inside cancer cells and destroy the activity of the rogue gene. This is a difficult but not impossible task, made easier by the deeper understanding of the biological processes revealed in this study."

The research was funded by UK-based charity the Association of International Cancer Research (AICR), with additional support from the Big C Charity and the British Skin Foundation.

Dr Mark Matfield, scientific co-ordinator of AICR, said: "This is a very exciting new discovery and a perfect example of the way that basic research into cancer can open up ways to develop new ways to treat cancer."

The initial discovery was made while researchers were studying a group of natural cancer cell inhibitors（抑制剂） called 'Smads'.

Dr Surinder Soond, who spearheaded（带头，做先锋） the experimental work in the laboratory, said: "This is a very novel and exciting approach to treating cancer and the spread of tumours which holds great potential."