In the Old West, camps sent smoke signals across distances to share key developments or strategy. Likewise, two important signaling molecules1 communicate across nerve cells to regulate electrical and chemical activity, neuroscientists from the UT Health Science Center San Antonio reported today. The findings in rodent2(啮齿动物) models have implications for potential future treatment of epilepsy(癫痫) , stroke and other problems, the researchers said.
"We now have novel targets for therapeutic3 intervention4 for a range of neurological and cardiovascular(心血管的) diseases, including stroke, epilepsy, dementia, hypertension, mental illness and others," said senior author Mark S. Shapiro, Ph.D., professor of physiology5 at the Health Science Center. "This study should guide clinicians and pharmaceutical6 companies in developing new therapies against mental, neurological, cardiovascular or cerebrovascular(脑血管的) diseases that afflict7 many millions of people."
By isolating8 nerve cells from rats, the San Antonio team found a relationship between signaling enzymes9 called phosphoinositide(磷酸肌醇) kinases(激酶) and calcium10 ions. Calcium transport and levels of calcium concentrations inside nerve cells are extremely important for proper neurobiological function, Dr. Shapiro said.
In epilepsy, for example, it is thought that the hyper-excitability in the brain causes abnormal elevations11 of intracellular calcium ions, which is extremely toxic12. Thus, epileptic seizures13 often predispose people to additional seizures, as the normal regulation of brain activity increasingly breaks down.
The study is in the Jan. 7 issue of the Journal of Biological Chemistry.