科学家揭开砷化合物有毒亦可治病之谜
文章来源:未知 文章作者:meng 发布时间:2010-10-14 03:23 字体: [ ]  进入论坛
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Scientists have solved an important mystery about why an arsenic1(砷的) compound, called arsenite(亚砷酸盐) , can kill us, and yet function as an effective therapeutic2 agent against disease and infections. According to new research published in the October 2010 issue of Genetics (http://www.genetics.org) scientists from Johns Hopkins, Baylor and Stanford discovered that arsenite, a common water contaminant in many parts of the world, affects a special protein folding machine in yeast3(酵母,泡沫) , called TCP, also present in humans. This information not only opens the doors to developing safer therapeutic alternatives to arsenite-based medicines, but it may allow researchers counter the negative effects of arsenite poisoning. "By better understanding arsenite, we might be able to protect humans from its hazards(危险,危害) in the future," said Jef D. Boeke, Ph.D., co-author of the study from the Department of Molecular4 Biology and Genetics and The High Throughput Biology Center at The Johns Hopkins University School of Medicine in Baltimore. "Arsenite also has beneficial effects, and by focusing on these, we might be able to find safer ways to reap the beneficial effects without the inherent risks involved in using a compound derived5 from arsenic."

To make this discovery, scientists used advanced genomic tools and biochemical experiments to show that arsenic disturbs functions of the machinery6 (chaperonin complex) required for proper folding and maturation of several proteins and protein complexes within yeast cells. This mechanism7 of action by arsenic is not unique to yeast, as it has been shown to exist in a range of organisms from bacteria to mammals.

"As the human population grows, freshwater supplies become increasingly precious, but unfortunately some of this water has been contaminated(污染,弄脏) with arsenite," said Mark Johnston, Editor-in-Chief of the journal Genetics. "The more we learn about how this compound affects our bodies, the more we'll eventually be able to counter its deadly effects. In addition, we know that under certain controlled doses, arsenite has therapeutic value. This research hopefully gets us closer to a new generation of drugs that achieve maximum benefit with minimum risk."



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1 arsenic 2vSz4     
n.砒霜,砷;adj.砷的
参考例句:
  • His wife poisoned him with arsenic.他的妻子用砒霜把他毒死了。
  • Arsenic is a poison.砒霜是毒药。
2 therapeutic sI8zL     
adj.治疗的,起治疗作用的;对身心健康有益的
参考例句:
  • Therapeutic measures were selected to fit the patient.选择治疗措施以适应病人的需要。
  • When I was sad,music had a therapeutic effect.我悲伤的时候,音乐有治疗效力。
3 yeast 7VIzu     
n.酵母;酵母片;泡沫;v.发酵;起泡沫
参考例句:
  • Yeast can be used in making beer and bread.酵母可用于酿啤酒和发面包。
  • The yeast began to work.酵母开始发酵。
4 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
5 derived 6cddb7353e699051a384686b6b3ff1e2     
vi.起源;由来;衍生;导出v.得到( derive的过去式和过去分词 );(从…中)得到获得;源于;(从…中)提取
参考例句:
  • Many English words are derived from Latin and Greek. 英语很多词源出于拉丁文和希腊文。 来自《简明英汉词典》
  • He derived his enthusiasm for literature from his father. 他对文学的爱好是受他父亲的影响。 来自《简明英汉词典》
6 machinery CAdxb     
n.(总称)机械,机器;机构
参考例句:
  • Has the machinery been put up ready for the broadcast?广播器材安装完毕了吗?
  • Machinery ought to be well maintained all the time.机器应该随时注意维护。
7 mechanism zCWxr     
n.机械装置;机构,结构
参考例句:
  • The bones and muscles are parts of the mechanism of the body.骨骼和肌肉是人体的组成部件。
  • The mechanism of the machine is very complicated.这台机器的结构是非常复杂的。
TAG标签: water research disease
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