c-Met蛋白可作为甲状腺转移性肝癌的生物标记
文章来源:未知 文章作者:meng 发布时间:2010-09-29 02:43 字体: [ ]  进入论坛
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Met may be a promising1 personalized treatment method for approximately 45 percent of patients with hepatocellular carcinoma (HCC肝细胞癌) who have c-Met-positive tumors, according to study results presented at the Fourth AACR International Conference on Molecular3 Diagnostics in Cancer Therapeutic4 Development. HCC is the most common primary malignant5(恶性的,有害的) tumor2 of the liver; c-Met is a receptor for hepatocyte(肝细胞) growth factor that appears to drive liver cancer growth, invasion and metastasis(转移,新陈代谢) .

"Current therapies for HCC patients are ' one size fits all(一刀切,一体适用) .' We propose that molecular profiling will enable better therapy for HCC patients with a c-Met positive tumor," said Hanning You, M.D., Ph.D., postdoctoral fellow working in the laboratory of C. Bart Rountree, M.D., in the departments of pediatrics(小儿科) and pharmacology(药物学) , at the Pennsylvania State University College of Medicine, Hershey, Pa.

Using a preclinical translational study to validate6 c-Met as a target for HCC, You and colleagues found c-Met was highly overexpressed in metastatic(转移性的) liver cancer cells.

"By targeting c-Met we were able to suppress tumor growth in vivo(在活体内) and kill these metastatic liver cancer cells," said You.

Since c-Met inhibitor stopped proliferation and tumor growth of metastatic HCC cells, the researchers concluded that c-Met might be a potential personalized target of metastatic HCC. In addition, they found that results of a separate meta-analysis of six studies and 1,051 patients showed that c-Met activation7 is associated with poor prognosis in HCC.



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1 promising BkQzsk     
adj.有希望的,有前途的
参考例句:
  • The results of the experiments are very promising.实验的结果充满了希望。
  • We're trying to bring along one or two promising young swimmers.我们正设法培养出一两名有前途的年轻游泳选手。
2 tumor fKxzm     
n.(肿)瘤,肿块(英)tumour
参考例句:
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
3 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
4 therapeutic sI8zL     
adj.治疗的,起治疗作用的;对身心健康有益的
参考例句:
  • Therapeutic measures were selected to fit the patient.选择治疗措施以适应病人的需要。
  • When I was sad,music had a therapeutic effect.我悲伤的时候,音乐有治疗效力。
5 malignant Z89zY     
adj.恶性的,致命的;恶意的,恶毒的
参考例句:
  • Alexander got a malignant slander.亚历山大受到恶意的诽谤。
  • He started to his feet with a malignant glance at Winston.他爬了起来,不高兴地看了温斯顿一眼。
6 validate Jiewm     
vt.(法律)使有效,使生效
参考例句:
  • You need an official signature to validate the order.你要有正式的签字,这张汇票才能生效。
  • In order to validate the agreement,both parties sign it.为使协议有效,双方在上面签了字。
7 activation 24eed33ee38027d124839f0fcdf6adcb     
n. 激活,催化作用
参考例句:
  • A computer controls the activation of an air bag.电脑控制着气囊的启动。
TAG标签: cells patients cancer tumor
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