新发现有助医生评估个人皮肤癌患病几率
文章来源:未知 文章作者:meng 发布时间:2010-06-03 01:26 字体: [ ]  进入论坛
(单词翻译:双击或拖选)

As people head to the beach this summer, very few if any(若有的话) , really know how likely they are to develop skin cancer from their outdoor fun. That's about to change, thanks to a new discovery by an international team of scientists that makes it possible for doctors to access people's personal risk for skin cancer. In a new research report appearing online in The FASEB Journal(美国实验生物学学会联合会杂志) (http://www.fasebj.org), these researchers describe for the first time the chain of molecular1(分子的) events that increase one's risk of skin cancer. This discovery may lead to new tests that access personal skin cancer risk as well as a new generation of sunscreens(防晒霜) that increase the skin's ability to protect itself from the sun's damaging rays.

"Our study heralds3(通报,宣布) the onset4 of personalized medicine for individuals who carry a change in the MC1R gene2," said Zalfa A. Abdel-Malek, Ph.D., a researcher involved in the work from the Department of Dermatology(皮肤病学) at the University of Cincinnati. "The data we have obtained allows us to better predict which individuals will be at risk for skin cancer, as well as potentially why and to what degree. In the future, genetic5 testing for MC1R gene changes may be clinically available so that individuals can be made aware of the molecular basis of their risk prior to development of cancer."

Abdel-Malek and colleagues found that when a pigmentation(色素淀积,染色) gene called the "melanocortin(黑素肾上腺皮质激素) 1 receptor" or MC1R does not function properly, skin cells do not respond to a hormone7, called α-MSH, which causes cells to produce dark pigmentation to protect themselves from ultraviolet rays(紫外线) . To make this discovery, the researchers studied 21 human skin cell cultures that express the MC1R gene in different ways. Each culture was studied for expression of genetic changes of MC1R, pigment6 levels and the ability to respond to α-MSH. The researchers also exposed the cell cultures to ultraviolet rays and measured the amount of DNA8 damage and the rate of its repair, as well as the percent of surviving melanocytes(生黑色素细胞) . Then the scientists inserted a normal version of the MC1R gene into the skin cells and found that they responded properly to ultraviolet light by producing the pigment necessary to protect themselves. These results give researchers testable strategies to reduce or prevent skin cancer. The results also suggest that it may be possible to develop drugs or a new generation of sunscreens that restore the lost function of MC1R.

"This research permits us know our own, personal risk for skin cancer." said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "We've known for a long time that smearing9(弄脏) on sunscreen is the best way to avoid skin cancer, but never how much or what kind. This study points the way to new kinds of sunscreens that restore their skin's ability to protect itself from DNA damage."



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1 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
2 gene WgKxx     
n.遗传因子,基因
参考例句:
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
3 heralds 85a7677643514d2e94585dc21f41b7ab     
n.使者( herald的名词复数 );预报者;预兆;传令官v.预示( herald的第三人称单数 );宣布(好或重要)
参考例句:
  • The song of birds heralds the approach of spring. 百鸟齐鸣报春到。 来自《现代英汉综合大词典》
  • The wind sweeping through the tower heralds a rising storm in the mountain. 山雨欲来风满楼。 来自《现代汉英综合大词典》
4 onset bICxF     
n.进攻,袭击,开始,突然开始
参考例句:
  • The drug must be taken from the onset of the infection.这种药必须在感染的最初期就开始服用。
  • Our troops withstood the onset of the enemy.我们的部队抵挡住了敌人的进攻。
5 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
6 pigment gi0yg     
n.天然色素,干粉颜料
参考例句:
  • The Romans used natural pigments on their fabrics and walls.古罗马人在织物和墙壁上使用天然颜料。
  • Who thought he might know what the skin pigment phenomenon meant.他自认为可能知道皮肤色素出现这种现象到底是怎么回事。
7 hormone uyky3     
n.荷尔蒙,激素,内分泌
参考例句:
  • Hormone implants are used as growth boosters.激素植入物被用作生长辅助剂。
  • This hormone interacts closely with other hormones in the body.这种荷尔蒙与体內其他荷尔蒙紧密地相互作用。
8 DNA 4u3z1l     
(缩)deoxyribonucleic acid 脱氧核糖核酸
参考例句:
  • DNA is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
  • Gene mutations are alterations in the DNA code.基因突变是指DNA密码的改变。
9 smearing acc077c998b0130c34a75727f69ec5b3     
污点,拖尾效应
参考例句:
  • The small boy spoilt the picture by smearing it with ink. 那孩子往画上抹墨水把画给毁了。
  • Remove the screen carefully so as to avoid smearing the paste print. 小心的移开丝网,以避免它弄脏膏印。
TAG标签: risk cancer skin personal
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