文章来源:未知 文章作者:meng 发布时间:2010-04-09 01:47 字体: [ ]  进入论坛

A new discovery raises hope that autism(孤独症,自闭症) may be more easily diagnosed and that its effects may be more reversible(可逆的,可撤销的) than previously1 thought. In a new study appearing online in The FASEB Journal (http://www.fasebj.org), scientists have identified a way to detect the disorder2 using blood and have discovered that drugs which affect the methylation(甲基化) state ("DNA3 tagging") of genes4 could reverse autism's effects. This type of drug is already being used in some cancer treatments. "As the mother of a now 22-year-old son with an autism spectrum5(光谱,频谱) disorder, I hope that our studies as well as those of others, will lead to therapies that are designed to address specific deficiencies(缺陷,不足) that are caused by autism, thus improving the lives of affected6 individuals," said Valerie W. Hu, Ph.D., one of the researchers involved in the work from the Department of Biochemistry and Molecular7 Biology at The George Washington University Medical Center in Washington, D.C. "Since autism is very diverse in the array of symptoms present in any given individual, it is first necessary to be able to identify specific deficits8 in each individual in order to design and then prescribe the best treatment. As an example of this personalized approach to medicine, we identified RORA as one of the genes that was altered specifically in the sub group of autistic individuals who exhibited severe language deficits."

To make their discovery, Hu and colleagues identified chemical changes in DNA taken from cells of identical twins and sibling9(同辈,兄弟姐妹) pairs, in which only one of the twins or siblings10 was diagnosed with autism. The researchers then compared genes that showed changes in DNA tagging (methylation) with a list of genes that showed different levels of expression from these same individuals. Then the scientists studied the amount of protein product produced by two genes that appear on both lists in autistic and control regions of the cerebellum(小脑) and frontal cortex(前额叶) of the brain. They found that both proteins, as predicted by the observed increase in DNA tagging, were reduced in the autistic brain. This suggests that blocking the chemical tagging of these genes may reverse symptoms of the disorder and demonstrates the feasibility(可行性,可能性) of using more easily accessible cells from blood (or other non-brain tissues) for diagnostic screening.

"For far too long, autism research has been side-tracked by the cranky(暴躁的,古怪的) notion that it's caused by the MMR vaccine," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Studies like this, which define genetic11 and epigenetic(外成的,后生的) changes in discrete12 subgroups of the autism spectrum, offer real hope that effective treatments and accurate diagnosis13 are closer at hand."


1 previously bkzzzC     
  • The bicycle tyre blew out at a previously damaged point.自行车胎在以前损坏过的地方又爆开了。
  • Let me digress for a moment and explain what had happened previously.让我岔开一会儿,解释原先发生了什么。
2 disorder Et1x4     
  • When returning back,he discovered the room to be in disorder.回家后,他发现屋子里乱七八糟。
  • It contained a vast number of letters in great disorder.里面七零八落地装着许多信件。
3 DNA 4u3z1l     
(缩)deoxyribonucleic acid 脱氧核糖核酸
  • DNA is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
  • Gene mutations are alterations in the DNA code.基因突变是指DNA密码的改变。
4 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
5 spectrum Trhy6     
  • This is a kind of atomic spectrum.这是一种原子光谱。
  • We have known much of the constitution of the solar spectrum.关于太阳光谱的构成,我们已了解不少。
6 affected TzUzg0     
  • She showed an affected interest in our subject.她假装对我们的课题感到兴趣。
  • His manners are affected.他的态度不自然。
7 molecular mE9xh     
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
8 deficits 08e04c986818dbc337627eabec5b794e     
n.不足额( deficit的名词复数 );赤字;亏空;亏损
  • The Ministry of Finance consistently overestimated its budget deficits. 财政部一贯高估预算赤字。 来自《简明英汉词典》
  • Many of the world's farmers are also incurring economic deficits. 世界上许多农民还在遭受经济上的亏损。 来自辞典例句
9 sibling TEszc     
  • Many of us hate living in the shadows of a more successful sibling.我们很多人都讨厌活在更为成功的手足的阴影下。
  • Sibling ravalry has been common in this family.这个家里,兄弟姊妹之间的矛盾很平常。
10 siblings 709961e45d6808c7c9131573b3a8874b     
n.兄弟,姐妹( sibling的名词复数 )
  • A triplet sleeps amongst its two siblings. 一个三胞胎睡在其两个同胞之间。 来自《简明英汉词典》
  • She has no way of tracking the donor or her half-siblings down. 她没办法找到那个捐精者或她的兄弟姐妹。 来自时文部分
11 genetic PgIxp     
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
12 discrete 1Z5zn     
  • The picture consists of a lot of discrete spots of colour.这幅画由许多不相连的色点组成。
  • Most staple fibers are discrete,individual entities.大多数短纤维是不联系的单独实体。
13 diagnosis GvPxC     
  • His symptoms gave no obvious pointer to a possible diagnosis.他的症状无法作出明确的诊断。
  • The engineer made a complete diagnosis of the bridge's collapse.工程师对桥的倒塌做一次彻底的调查分析。
TAG标签: DNA cancer autism DIscovery