文章来源:未知 文章作者:meng 发布时间:2010-01-17 01:47 字体: [ ]  进入论坛

"Our study reveals the interaction of genetic2 and environmental factors such as dietary habits in the pathogenesis发病机理 of Parkinson's disease," explained Dr. Matthias Elstner of the Neurological Clinic of LMU and Helmholtz Zentrum München, lead author of the study. In addition, this genome-wide expression and association study confirms that vitamin B6 status and metabolism新陈代谢 significantly influence both disease risk and therapy response (Annals of Neurology, January, 2010). Scientists of the two Munich universities and Helmholtz Zentrum München investigated neurons神经原 in the brain to determine which genes3 modify their activity in Parkinson's disease. Among other findings, the research group detected increased activity of the pyridoxal吡哆醛 kinase激酶,致活酶 gene1. In a subsequent international cooperation project, the researchers compared this gene in over 1,200 Parkinson patients with the genetic data of more than 2,800 healthy test subjects. In doing so, they discovered a gene variant5 which increases the risk for Parkinson's disease and which may lead to a modified quantity or activity of the enzyme6 pyridoxal kinase (PDXK) in the brain. In combination with genetic association analysis, the innovative7 method used here – single cell expression profiling of dopaminergic多巴胺能的 neurons – opens up new possibilities for analyzing8 genetic risk factors.

PDXK converts Vitamin B6 from food sources into its physiologically9 active form, which is the prerequisite先决条件 for the production of the neurotransmitter神经传递素 dopamine多巴胺. Parkinson's disease is linked to the accelerated aging and dying off of neurons that produce dopamine. The decreased synthesis of this neurotransmitter explains most of the disease symptoms: The gradual progression of the neurological disease is accompanied by muscle rigor严厉,精确 and tremor12 and a slowing of movement (bradykinesia动作迟缓). Besides the constraints13 on daily life caused by these symptoms, the postural14 instability of the body can lead to dangerous falls. Moreover, in the course of the disease sensory15 symptoms like paresthesia感觉异常, vegetative disorders16 (e.g. bladder dysfunction) and depression as well as other psychological changes can occur.

"Our study elucidates说明,阐明 how genetic and environmental factors such as dietary habits interact in the pathogenesis of Parkinson's disease," explained Dr. Matthias Elstner of the Neurological Clinic of LMU and Helmholtz Zentrum München, who is lead author of the study. Dr. Holger Prokisch, head of the research team studying mitochondrial线粒体的 diseases at Helmholtz Zentrum München and TU München, added: "Although this variant is responsible for only a slight contribution to the overall risk for Parkinson's disease, our findings could aid in developing individualized therapies. "


1 gene WgKxx     
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
2 genetic PgIxp     
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
3 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
4 metabolism 171zC     
  • After years of dieting,Carol's metabolism was completely out of whack.经过数年的节食,卡罗尔的新陈代谢完全紊乱了。
  • All living matter undergoes a process of metabolism.生物都有新陈代谢。
5 variant GfuzRt     
  • We give professional suggestions according to variant tanning stages for each customer.我们针对每位顾客不同的日晒阶段,提供强度适合的晒黑建议。
  • In a variant of this approach,the tests are data- driven.这个方法的一个变种,是数据驱动的测试。
6 enzyme cPozF     
  • Above a certain temperature,the enzyme molecule will become unfolded.超过一定温度,酶分子将会展开。
  • An enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
7 innovative D6Vxq     
  • Discover an innovative way of marketing.发现一个创新的营销方式。
  • He was one of the most creative and innovative engineers of his generation.他是他那代人当中最富创造性与革新精神的工程师之一。
8 analyzing be408cc8d92ec310bb6260bc127c162b     
v.分析;分析( analyze的现在分词 );分解;解释;对…进行心理分析n.分析
  • Analyzing the date of some socialist countries presents even greater problem s. 分析某些社会主义国家的统计数据,暴露出的问题甚至更大。 来自辞典例句
  • He undoubtedly was not far off the mark in analyzing its predictions. 当然,他对其预测所作的分析倒也八九不离十。 来自辞典例句
9 physiologically QNfx3     
  • Therefore, the liver and gallbladder cannot be completely separated physiologically and pathologically. 因此,肝胆在生理和病理上不能完全分离。
  • Therefore, the liver and gallbladder are closely related physiologically and pathologically. 因此,肝胆在生理和病理上紧密联系。
10 prerequisite yQCxu     
  • Stability and unity are a prerequisite to the four modernizations.安定团结是实现四个现代化的前提。
  • It is a prerequisite of entry to the profession that you pass the exams.做这一行的先决条件是要通过了有关的考试。
11 rigor as0yi     
  • Their analysis lacks rigor.他们的分析缺乏严谨性。||The crime will be treated with the full rigor of the law.这一罪行会严格依法审理。
12 tremor Tghy5     
  • There was a slight tremor in his voice.他的声音有点颤抖。
  • A slight earth tremor was felt in California.加利福尼亚发生了轻微的地震。
13 constraints d178923285d63e9968956a0a4758267e     
强制( constraint的名词复数 ); 限制; 约束
  • Data and constraints can easily be changed to test theories. 信息库中的数据和限制条件可以轻易地改变以检验假设。 来自英汉非文学 - 科学史
  • What are the constraints that each of these imply for any design? 这每种产品的要求和约束对于设计意味着什么? 来自About Face 3交互设计精髓
14 postural f31c5f2e74a3d972489241c95a07064d     
adj. 姿势的,体位的
  • Chest percussion and vibration are used with postural drainage to help dislodge secretions. 在做体位引流时要敲击和振动胸部帮助分泌物松动排出。
  • And as with slumping, over-arching can also be a simple postural habit. 就像弯腰驼背,过度挺直也可能只是一种习惯性姿势。
15 sensory Azlwe     
  • Human powers of sensory discrimination are limited.人类感官分辨能力有限。
  • The sensory system may undergo long-term adaptation in alien environments.感觉系统对陌生的环境可能经过长时期才能适应。
16 disorders 6e49dcafe3638183c823d3aa5b12b010     
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调
  • Reports of anorexia and other eating disorders are on the increase. 据报告,厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
  • The announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》
17 elucidates 40206386092f3c846952e2a91cce63ce     
v.阐明,解释( elucidate的第三人称单数 )
  • Part Two: This section elucidates the connotation operative ability in geography. 第二部分,阐述了地理实践能力内涵。 来自互联网
  • This review mostly elucidates advances in medication of primary osteoporosis. 在此主要介绍原发性骨质疏松症的药物治疗进展。 来自互联网
TAG标签: genetic disease Parkinson