阻止丙肝病毒复制的关键步骤
文章来源:未知 文章作者:enread 发布时间:2015-05-21 07:01 字体: [ ]  进入论坛
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New research from the University of Southampton has identified how changes in the cell membrane1 play a pivotal role in how the Hepatitis C virus replicates3. By understanding this process, the researchers hope to investigate how to prevent the changes and potentially develop therapeutic4 drugs to combat the Hepatitis C virus (HCV), which infects an estimated 170 million people globally.
 
When HCV infects a cell it uses one of its proteins, NS4B, to form a lipid-rich structure called the 'membranous5 web'. This structure contains 'reaction centres', where the virus can replicate2 protected from the host cell's antivirus defences. 
 
Within NS4B, the AH2 peptide plays a crucial role in remodelling6 lipid membranes7 to form the membranous web. However, it is not understood how AH2 causes these changes.
 
Using nuclear magnetic resonance8 (NMR) spectroscopy in conjunction with molecular9 dynamics10 (MD), Southampton researchers showed that AH2 interacts with negatively charged lipid membranes within the cell. It causes them to become more malleable11, a property almost certainly important in reaction centre formation. When introduced into membranes with non-charged lipids, AH2 behaved differently, forming larger complexes resulting in limited deformation12 of the membrane, consistent with a separate role in early steps of membranous web formation. 
 
Co-author of the study Dr Phil Williamson, Lecturer in Biological Sciences, says: "Now we begin to understand at the molecular level how HCV hijacks13 cellular14 membranes to aid its replications, we can use this information to help identify novel sites for therapeutic intervention15 to target HCV and similar viruses."
 
Co-author Dr Chris McCormick, from Medicine at the University of Southampton, adds: "This gives us an important lead on how changes in lipid content in the membranous web help drive membrane remodelling. The challenge for us now is to use the same interdisciplinary approach to link these activities with other maturation events seen inside the infected cell."


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1 membrane H7ez8     
n.薄膜,膜皮,羊皮纸
参考例句:
  • A vibrating membrane in the ear helps to convey sounds to the brain.耳膜的振动帮助声音传送到大脑。
  • A plastic membrane serves as selective diffusion barrier.一层塑料薄膜起着选择性渗透屏障的作用。
2 replicate PVAxN     
v.折叠,复制,模写;n.同样的样品;adj.转折的
参考例句:
  • The DNA of chromatin must replicate before cell division.染色质DNA在细胞分裂之前必须复制。
  • It is also easy to replicate,as the next subsection explains.就像下一个小节详细说明的那样,它还可以被轻易的复制。
3 replicates 2cb25c60b573b908924058afde2ecd5a     
复制( replicate的第三人称单数 ); 重复; 再造; 再生
参考例句:
  • The bluetongue virus replicates in the insect. 蓝舌病病毒在这种昆虫体内繁殖。
  • The chameleon's skin replicates the pattern of its surroundings. 变色龙的皮肤可随环境的模式而改变颜色。
4 therapeutic sI8zL     
adj.治疗的,起治疗作用的;对身心健康有益的
参考例句:
  • Therapeutic measures were selected to fit the patient.选择治疗措施以适应病人的需要。
  • When I was sad,music had a therapeutic effect.我悲伤的时候,音乐有治疗效力。
5 membranous d3188e188c6974b4ce79a428f143eed0     
adj.膜的,膜状的
参考例句:
  • Others are born live, after struggling to break free from a membranous egg sac. 其余的是冲破膜状蛋囊而出生的。 来自电影对白
  • Thellos thellon, membranous layer of life is our only home. 薄薄的膜层就是咱们独一的家园。 来自互联网
6 remodelling 965d241a7ef7fe602b7d6e8cc7bc56ae     
v.改变…的结构[形状]( remodel的现在分词 )
参考例句:
  • That shabby street needs remodelling. 那条陋街需要重建。 来自辞典例句
  • Function-forming and remodelling collagen, reticular and elastic fibres and the ground substances. 合成蛋白质,构成疏松结缔组织的纤维和基质成分。 来自互联网
7 membranes 93ec26b8b1eb155ef0aeaa845da95972     
n.(动物或植物体内的)薄膜( membrane的名词复数 );隔膜;(可起防水、防风等作用的)膜状物
参考例句:
  • The waste material is placed in cells with permeable membranes. 废液置于有渗透膜的槽中。 来自辞典例句
  • The sarcoplasmic reticulum is a system of intracellular membranes. 肌浆网属于细胞内膜系统。 来自辞典例句
8 resonance hBazC     
n.洪亮;共鸣;共振
参考例句:
  • Playing the piano sets up resonance in those glass ornaments.一弹钢琴那些玻璃饰物就会产生共振。
  • The areas under the two resonance envelopes are unequal.两个共振峰下面的面积是不相等的。
9 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
10 dynamics NuSzQq     
n.力学,动力学,动力,原动力;动态
参考例句:
  • In order to succeed,you must master complicated knowledge of dynamics.要取得胜利,你必须掌握很复杂的动力学知识。
  • Dynamics is a discipline that cannot be mastered without extensive practice.动力学是一门不做大量习题就不能掌握的学科。
11 malleable Qwdyo     
adj.(金属)可锻的;有延展性的;(性格)可训练的
参考例句:
  • Silver is the most malleable of all metals.银是延展性最好的金属。
  • Scientists are finding that the adult human brain is far more malleable than they once thought.科学家发现成人大脑的可塑性远超过他们之前认识到的。
12 deformation 59ryp     
n.形状损坏;变形;畸形
参考例句:
  • The deformation frequencies are not sufficiently distinctive.其变形频率不是十分明显的。
  • The calculated deformation is almost equal to the real situation by measurement.经检测,计算变形量与实际情况基本一致。
13 hijacks 678bf5894e05ba78937af53c72ee0477     
劫持( hijack的名词复数 ); 绑架; 拦路抢劫; 操纵(会议等,以推销自己的意图)
参考例句:
  • Just as life infiltrates matter mercilessly and then hijacks it forever, cultural life hijacks biology. 正如生命无情地浸入物质并永远地将其劫持,文化生命也劫持了生物界。
14 cellular aU1yo     
adj.移动的;细胞的,由细胞组成的
参考例句:
  • She has a cellular telephone in her car.她的汽车里有一部无线通讯电话机。
  • Many people use cellular materials as sensitive elements in hygrometers.很多人用蜂窝状的材料作为测量温度的传感元件。
15 intervention e5sxZ     
n.介入,干涉,干预
参考例句:
  • The government's intervention in this dispute will not help.政府对这场争论的干预不会起作用。
  • Many people felt he would be hostile to the idea of foreign intervention.许多人觉得他会反对外来干预。
TAG标签: virus cell membrane
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