桥粒斑蛋白的尾巴
文章来源:未知 文章作者:enread 发布时间:2015-03-04 07:28 字体: [ ]  进入论坛
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Cells control the adhesion protein desmoplakin by modifying the tail end of the protein, and this process goes awry1 in some patients with arrhythmogenic cardiomyopathy, according to a study in The Journal of Cell Biology. Desmoplakin is a key component2 of the adhesive3 junctions4, known as desmosomes, that link cells together in tissues that undergo severe strain, such as the heart and skin. Its role is to anchor parts of the cytoskeleton to sites of cell-to-cell contact. Kathleen Green and colleagues at Northwestern University Feinberg School of Medicine determined5 how modifying desmoplakin's intracellular tail with phosphate and methyl groups affects the protein's interaction with the cytoskeleton.
 
The enzyme6 GSK3 added phosphate groups to desmoplakin's tail, and its loss spurred the protein to shift from desmosomes to the intermediate filaments7. Blocking GSK3 slowed desmoplakin's relocation from the intermediate filaments to the cells' boundaries during desmosome formation.
 
Methylation of four arginine residues8 in desmoplakin's tail had similar effects as phosphorylation. The team also found that methylation of one particular arginine, R2834, which is mutated in some patients with arrhythmogenic cardiomyopathy, was necessary for the phosphorylation of most tail serine residues because this modification9 drew GSK3 to desmoplakin. Mutating this arginine delayed desmoplakin's assembly into desmosomes, weakening intercellular connections so that cell layers broke apart under mechanical stress.
 
The results show that phosphorylation and methylation make desmoplakin more dynamic. Cells might be able to fine-tune desmoplakin's characteristics by adding and removing phosphates and methyl groups, and defects in this regulatory process might contribute to skin and heart diseases.


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1 awry Mu0ze     
adj.扭曲的,错的
参考例句:
  • She was in a fury over a plan that had gone awry. 计划出了问题,她很愤怒。
  • Something has gone awry in our plans.我们的计划出差错了。
2 component epSzv     
n.组成部分,成分,元件;adj.组成的,合成的
参考例句:
  • Each component is carefully checked before assembly.每个零件在装配前都经过仔细检查。
  • Blade and handle are the component parts of a knife.刀身和刀柄是一把刀的组成部分。
3 adhesive CyVzV     
n.粘合剂;adj.可粘着的,粘性的
参考例句:
  • You'll need a strong adhesive to mend that chair. 你需要一种粘性很强的东西来修理那把椅子。
  • Would you give me an adhesive stamp?请给我一枚带胶邮票好吗?
4 junctions 8d6818d120fa2726af259fc9dc6c7c61     
联结点( junction的名词复数 ); 会合点; (公路或铁路的)交叉路口; (电缆等的)主结点
参考例句:
  • Metals which were mutually soluble would tend to give strong junctions. 可互溶的金属趋向于产生牢固的结合点。
  • Some adhering junctions are present as narrow bands connecting two cells. 有些粘附连接以一窄带的形式连接两个细胞。
5 determined duszmP     
adj.坚定的;有决心的
参考例句:
  • I have determined on going to Tibet after graduation.我已决定毕业后去西藏。
  • He determined to view the rooms behind the office.他决定查看一下办公室后面的房间。
6 enzyme cPozF     
n.酵素,酶
参考例句:
  • Above a certain temperature,the enzyme molecule will become unfolded.超过一定温度,酶分子将会展开。
  • An enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
7 filaments 82be78199276cbe86e0e8b6c084015b6     
n.(电灯泡的)灯丝( filament的名词复数 );丝极;细丝;丝状物
参考例句:
  • Instead, sarcomere shortening occurs when the thin filaments'slide\" by the thick filaments. 此外,肌节的缩短发生于细肌丝沿粗肌丝“滑行”之际。 来自辞典例句
  • Wetting-force data on filaments of any diameter and shape can easily obtained. 各种直径和形状的长丝的润湿力数据是易于测量的。 来自辞典例句
8 residues 3e5a3e323766c2626c2be0d6feafa1da     
n.剩余,余渣( residue的名词复数 );剩余财产;剩数
参考例句:
  • pesticide residues in fruit and vegetables 残留在水果和蔬菜中的杀虫剂
  • All organic and metallic residues on the wafers must be removed. 片子上所有的有机和金属残留物均必须清除。 来自辞典例句
9 modification tEZxm     
n.修改,改进,缓和,减轻
参考例句:
  • The law,in its present form,is unjust;it needs modification.现行的法律是不公正的,它需要修改。
  • The design requires considerable modification.这个设计需要作大的修改。
TAG标签: tail cells protein
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