Scientists have discovered a second code hiding within DNA¹. This second code contains information that changes how scientists read the instructions contained in DNA and interpret mutations to make sense of health and disease. A research team led by Dr. John Stamatoyannopoulos, University of Washington associate professor of genome sciences and of medicine, made the discovery. The findings are reported in the Dec. 13 issue of Science. The work is part of the Encyclopedia² of DNA Elements Project, also known as ENCODE. The National Human Genome Research Institute funded the multi-year, international effort. ENCODE aims to discover where and how the directions for biological functions are stored in the human genome.

 

Since the genetic⁴ code was deciphered（破译） in the 1960s, scientists have assumed that it was used exclusively to write information about proteins. UW scientists were stunned⁵ to discover that genomes use the genetic code to write two separate languages. One describes how proteins are made, and the other instructs the cell on how genes⁶ are controlled. One language is written on top of the other, which is why the second language remained hidden for so long.

 

"For over 40 years we have assumed that DNA changes affecting the genetic code solely⁷ impact how proteins are made," said Stamatoyannopoulos. "Now we know that this basic assumption about reading the human genome missed half of the picture. These new findings highlight that DNA is an incredibly powerful information storage device, which nature has fully⁸ exploited in unexpected ways."

 

The genetic code uses a 64-letter alphabet called codons. The UW team discovered that some codons（密码子）, which they called duons, can have two meanings, one related to protein sequence, and one related to gene³ control. These two meanings seem to have evolved in concert with each other. The gene control instructions appear to help stabilize⁹ certain beneficial features of proteins and how they are made.

 

The discovery of duons has major implications for how scientists and physicians interpret a patient's genome and will open new doors to the diagnosis¹⁰ and treatment of disease.

 

"The fact that the genetic code can simultaneously¹¹ write two kinds of information means that many DNA changes that appear to alter protein sequences may actually cause disease by disrupting gene control programs or even both mechanisms¹² simultaneously," said Stamatoyannopoulos.

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