文章来源:未知 文章作者:enread 发布时间:2012-11-21 05:44 字体: [ ]  进入论坛
Researchers at Wake Forest Baptist Medical Center have modified electrically-conductive polymers, commonly used in solar energy applications, to develop revolutionary polymer nanoparticles (PNs) for a medical application. When the nanoparticles are exposed to infrared1 light, they generate heat that can be used to kill colorectal(结肠直肠的) cancer cells. The study was directed by Assistant Professor of Plastic and Reconstructive Surgery, Nicole H. Levi-Polyachenko, Ph.D., and done in collaboration2 with colleagues at the Center for Nanotechnology and Molecular3 Materials at Wake Forest University. This study was recently published online, ahead of print, in the journal, Macromolecular Bioscience.
Levi-Polyachenko and her team discovered a novel formulation that gives the polymers two important capabilities4 for medical applications: the polymers can be made into nanoparticles that are easily dispersed5 in water and generate a lot of heat when exposed to infrared light.
Results of this study showed that when colorectal cancer cells incubated(孵化,培养) with the PNs were exposed to five minutes of infrared light, the treatment killed up to 95 percent of cells. "The results of this study demonstrate how new medical advancements6 are being developed from materials science research," said Levi-Polyachenko.
The team made polymer nanoparticles and showed that they could undergo repeated cycles of heating and cooling without affecting their heating ability. This offers advantages over metal nanoparticles, which can melt during photothermal treatments, leading to a loss of heating efficiency. This also allows for subsequent treatments to target cells that are resistant7 to heat-induced killing8.
A challenge with other electrically-conductive polymers that have recently been explored for photothermal(光热的) therapy is that these other polymers absorb across a wide range of infrared light. Christopher M. MacNeill, Ph.D., post-doctoral researcher at Wake Forest and first author on the paper, noted9 that, "we have specifically used electrically-conductive polymers designed to absorb a very narrow region of infrared light, and have also developed small, 50-65nm, polymer nanoparticles in order to optimize10 both biological transport as well as heat transfer." For example, 50nm is about 2000 times smaller than a human hair.
In addition, the new PNs are organic and did not show any evidence of toxicity11, alleviating12 concerns about the effect of nanoparticles that may potentially linger in the body.
"There is a lot more research that needs to be done so that these new nanoparticles can be used safely in patients," Levi-Polyachenko cautioned, "but the field of electrically-conductive polymers is broad and offers many opportunities to develop safe, organic nanoparticles for generating heat locally in a tissue. We are very enthusiastic about future medical applications using these new nanoparticles, including an alternative approach for treating colorectal cancer."
The study was funded by the Department of Plastic and Reconstructive Surgery at Wake Forest Baptist Medical Center.


1 infrared dx0yp     
  • Infrared is widely used in industry and medical science.红外线广泛应用于工业和医学科学。
  • Infrared radiation has wavelengths longer than those of visible light.红外辐射的波长比可见光的波长长。
2 collaboration bW7yD     
  • The two companies are working in close collaboration each other.这两家公司密切合作。
  • He was shot for collaboration with the enemy.他因通敌而被枪毙了。
3 molecular mE9xh     
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
4 capabilities f7b11037f2050959293aafb493b7653c     
n.能力( capability的名词复数 );可能;容量;[复数]潜在能力
  • He was somewhat pompous and had a high opinion of his own capabilities. 他有点自大,自视甚高。 来自辞典例句
  • Some programmers use tabs to break complex product capabilities into smaller chunks. 一些程序员认为,标签可以将复杂的功能分为每个窗格一组简单的功能。 来自About Face 3交互设计精髓
5 dispersed b24c637ca8e58669bce3496236c839fa     
adj. 被驱散的, 被分散的, 散布的
  • The clouds dispersed themselves. 云散了。
  • After school the children dispersed to their homes. 放学后,孩子们四散回家了。
6 advancements d9d88b0aa041a51f56ca9b4113bf311c     
n.(级别的)晋升( advancement的名词复数 );前进;进展;促进
  • Today, the pace of life is increasing with technological advancements. 当今, 随着科技进步,生活节奏不断增快。 来自《现代汉英综合大词典》
  • Great advancements in drought prediction have been made in recent years. 近年来,人们对干旱灾害的预报研究取得了长足的进步。 来自互联网
7 resistant 7Wvxh     
  • Many pests are resistant to the insecticide.许多害虫对这种杀虫剂有抵抗力。
  • They imposed their government by force on the resistant population.他们以武力把自己的统治强加在持反抗态度的人民头上。
8 killing kpBziQ     
  • Investors are set to make a killing from the sell-off.投资者准备清仓以便大赚一笔。
  • Last week my brother made a killing on Wall Street.上个周我兄弟在华尔街赚了一大笔。
9 noted 5n4zXc     
  • The local hotel is noted for its good table.当地的那家酒店以餐食精美而著称。
  • Jim is noted for arriving late for work.吉姆上班迟到出了名。
10 optimize WIoxY     
v.使优化 [=optimise]
  • We should optimize the composition of the Standing Committees.优化人大常委会组成人员的结构。
  • We should optimize our import mix and focus on bringing in advanced technology and key equipment.优化进口结构,着重引进先进技术和关键设备。
11 toxicity InYwc     
  • The hoarse grunt or squeal is characteristic of toxicity.嘶哑的哼声和叫声是中毒的特征。
  • Dieldrin is related to aldrin,and its toxicity to earthworms is similar.狄氏剂与艾氏剂有关,对蚯蚓的毒性是相似的。
12 alleviating dc7b7d28594f8dd2e6389293cd401ede     
减轻,缓解,缓和( alleviate的现在分词 )
  • If it's alleviating pain,who knows what else it's doing? 如果它减轻了疼痛,天知道还影响什么?
  • Measuring poverty is not the same as alleviating it, of course. 当然,衡量贫困和减轻贫困是截然不同的。
TAG标签: light cancer polymers