After a stroke the brain tries to protect itself by blocking all inflammation. However, this also makes the patient highly susceptible¹ to infection which can lead to death. Researchers have now discovered the mechanism² behind this response and how to possibly treat it. The research is published this month in the journal Science.

Using a mouse model, scientists at the University of Calgary's Faculty³ of Medicine have discovered Natural Killer⁴ T-cells (NKT) are the immune cells that get activated⁵ in the patient after a stroke. The cells suppress the immune system as the body tries to prevent inflammation to protect the brain. The researchers have also found a new drug that can stop the NKT cells from suppressing the immune system, stopping the infections.

"When we discovered that these novel NKT cells are important in fighting infection in stroke, we were able to specifically target them. This means that infections can be controlled without having to administer high levels of antibiotics⁶," says Paul Kubes, PhD, senior author of the study and director of the Snyder Institute at the University of Calgary. "This in its own right is important to avoid over-usage of antibiotics leading to development of anti-biotic resistant⁷ strains of bacteria."

Early indications are that NKT cells in humans behave very similarly to NKT cells in mice making this highly relevant to（有关的） human stroke.

"The research does not cure the stroke itself," says Connie Wong, PhD , also a co-author of the study and member of the Snyder Institute at the University of Calgary , "But by providing novel therapies it holds the promise to significantly decrease death rates associated with stroke."

This research publication has recently been recognized by Faculty of 1000, a website for researchers that identifies and evaluates the most significant articles from biomedical research publications.

The research was supported by the Canadian Institutes for Health Research (CIHR). Paul Kubes' research is also funded by Alberta Innovates⁸ -- Health Solutions.