文章来源:未知 文章作者:enread 发布时间:2011-08-28 01:28 字体: [ ]  进入论坛

For the first time, scientists can see pathways to stop a deadly brain cancer in its tracks. Researchers at Case Western Reserve University School of Medicine have imaged individual cancer cells and the routes they travel as the tumor1 spreads. The researchers used a novel cryo-imaging technique to obtain the unprecedented2 look at a mouse model of glioblastoma multiforme(多形性成胶质细胞瘤) , a particularly aggressive cancer that has no treatments to stop it from spreading.

A description of their work, and images, is being published Sept. 1 in the journal Cancer Research.

"We're able to see things we couldn't before, and we can use these images to understand how tumor cells invade and disperse3(分散,传播) ," said Susann M. Brady-Kalnay, a professor of molecular4 biology and microbiology at the Case Western Reserve School of Medicine, and senior author of the paper.

That information, in turn, can be used to help develop and test the effectiveness of drugs and other therapies used to treat the cancer, she said.

To obtain the view, the scientists used a model that included four different cell lines of brain cancers at various stages of tumor development and dispersion. The cancer cells were modified with fluorescent5 markers and implanted in the model's brain in collaboration6 with Biomedical Engineering Professor James Basilion's lab.

The cryo-imaging system, developed by David Wilson, also a professor of biomedical engineering at Case Western Reserve, disassembles the brain layer by layer and reassembles the model into a color three-dimensional digital image.

Using software and algorithms(算法) designed by the researchers, they are able to differentiate7 the main tumor mass, the blood vessels8 that feed the cancer and dispersing9 cells. The imaging system enables them to peer at single cells and see exactly where they are in the brain.

The lead researchers, Susan Burden-Gulley, Mohammed Qutaish and Kristin Sullivant, found that two cell lines, a human brain cancer LN229, and a rodent10 cancer CNS-1, best resemble the actions of glioblastoma multiforme in human patients.

Reconstructions11 of models of those two lines enabled the researchers to analyze12 the extent and patterns of cancer cell migration13 and dispersal from tumors along blood vessels and white matter tracts14 within the brain.

The ability to produce such clear and detailed15 images, the researchers say, will be invaluable16 when evaluating the potency17 of drugs and other therapies designed to block dispersal of glioblastoma multiforme cells.


1 tumor fKxzm     
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
2 unprecedented 7gSyJ     
  • The air crash caused an unprecedented number of deaths.这次空难的死亡人数是空前的。
  • A flood of this sort is really unprecedented.这样大的洪水真是十年九不遇。
3 disperse ulxzL     
  • The cattle were swinging their tails to disperse the flies.那些牛甩动着尾巴驱赶苍蝇。
  • The children disperse for the holidays.孩子们放假了。
4 molecular mE9xh     
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
5 fluorescent Zz2y3     
  • They observed the deflections of the particles by allowing them to fall on a fluorescent screen.他们让粒子落在荧光屏上以观察他们的偏移。
  • This fluorescent lighting certainly gives the food a peculiar color.这萤光灯当然增添了食物特别的色彩。
6 collaboration bW7yD     
  • The two companies are working in close collaboration each other.这两家公司密切合作。
  • He was shot for collaboration with the enemy.他因通敌而被枪毙了。
7 differentiate cm3yc     
  • You can differentiate between the houses by the shape of their chimneys.你可以凭借烟囱形状的不同来区分这两幢房子。
  • He never learned to differentiate between good and evil.他从未学会分辨善恶。
8 vessels fc9307c2593b522954eadb3ee6c57480     
n.血管( vessel的名词复数 );船;容器;(具有特殊品质或接受特殊品质的)人
  • The river is navigable by vessels of up to 90 tons. 90 吨以下的船只可以从这条河通过。 来自《简明英汉词典》
  • All modern vessels of any size are fitted with radar installations. 所有现代化船只都有雷达装置。 来自《现代汉英综合大词典》
9 dispersing dispersing     
adj. 分散的 动词disperse的现在分词形式
  • Whereas gasoline fumes linger close to the ground before dispersing. 而汽油烟气却靠近地面迟迟不散。
  • Earthworms may be instrumental in dispersing fungi or bacteria. 蚯蚓可能是散布真菌及细菌的工具。
10 rodent DsNyh     
  • When there is a full moon,this nocturnal rodent is careful to stay in its burrow.月圆之夜,这种夜间活动的啮齿类动物会小心地呆在地洞里不出来。
  • This small rodent can scoop out a long,narrow tunnel in a very short time.这种小啮齿动物能在很短的时间里挖出一条又长又窄的地道来。
11 reconstructions b68a36323018dfe7d6624e864a340794     
重建( reconstruction的名词复数 ); 再现; 重建物; 复原物
  • Multicolored reconstructions have been formed using (black and white) volume holographic plates. 利用黑白体积全息片已经做成了彩色重建象。
  • The method gives ways to evaluate collision speed in traffic accident reconstructions. 该模型为交通事故再现推算碰撞速度提供了有效实用的方法。
12 analyze RwUzm     
vt.分析,解析 (=analyse)
  • We should analyze the cause and effect of this event.我们应该分析这场事变的因果。
  • The teacher tried to analyze the cause of our failure.老师设法分析我们失败的原因。
13 migration mDpxj     
  • Swallows begin their migration south in autumn.燕子在秋季开始向南方迁移。
  • He described the vernal migration of birds in detail.他详细地描述了鸟的春季移居。
14 tracts fcea36d422dccf9d9420a7dd83bea091     
大片土地( tract的名词复数 ); 地带; (体内的)道; (尤指宣扬宗教、伦理或政治的)短文
  • vast tracts of forest 大片大片的森林
  • There are tracts of desert in Australia. 澳大利亚有大片沙漠。
15 detailed xuNzms     
  • He had made a detailed study of the terrain.他对地形作了缜密的研究。
  • A detailed list of our publications is available on request.我们的出版物有一份详细的目录备索。
16 invaluable s4qxe     
  • A computer would have been invaluable for this job.一台计算机对这个工作的作用会是无法估计的。
  • This information was invaluable to him.这个消息对他来说是非常宝贵的。
17 potency 9Smz8     
n. 效力,潜能
  • Alcohol increases the drug's potency.酒精能增加这种毒品的效力。
  • Sunscreen can lose its potency if left over winter in the bathroom cabinet.如果把防晒霜在盥洗室的壁橱里放一个冬天,就有可能失效。
TAG标签: cells cancer tumor