梅约诊所发明人工胰脏缓解糖尿病负担
文章来源:未知 文章作者:enread 发布时间:2011-06-26 06:49 字体: [ ]  进入论坛
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The 25.8 million Americans who have diabetes1 may soon be free of finger pricks2(刺,扎) and daily insulin dosing. Mayo Clinic endocrinologists(内分泌学家) Yogish Kudva, M.B.B.S., and Ananda Basu, M.B.B.S., M.D., are developing an artificial pancreas(胰腺) that will deliver insulin automatically and with an individualized precision never before possible. As part of this effort, Drs. Kudva and Basu will present their latest findings on how the mundane3(世俗的,平凡的) movements of everyday life affect blood sugar to the American Diabetes Association (http://www.diabetes.org/) meeting this month in San Diego.

"The effects of low-intensity physical activity, mimicking4 activities of daily living, measured with precise accelerometers(加速计) on glucose5(葡萄糖) variability in type 1 diabetes had not been examined," says Dr. Kudva.

Among his newest findings is that even basic physical activity after meals has a profound impact on blood sugar levels for people with type 1 diabetes (http://www.mayoclinic.com/health/type-1-diabetes/DS00329). "You would expect this result, but we wanted to know to what extent this phenomena6 would happen in people with type 1 diabetes," Dr. Kudva says.

Diabetics who engaged in low-grade physical activity after eating had blood sugar (http://www.mayoclinic.com/health/blood-sugar/MM00641) levels close to those of people with fully7 functioning pancreases. Those who remained sedentary(久坐的) after their meal, however, had elevated blood sugars.

The researchers plan to incorporate these findings into an artificial pancreas being developed at Mayo Clinic. The "Closed Loop System" under development includes a blood sugar monitor, an automatic insulin pump, a set of activity monitors that attach to the body and a central processing unit.

Clinical trials of the artificial pancreases are likely to begin in November with a handful of inpatient volunteers. Study participants will follow strict diet, exercise and insulin-delivery regimens in Mayo's Clinical Research Unit (http://ctsa.mayo.edu/resources/clinical-research-unit.html). Data will then be fed into an insulin-delivery algorithm(算法) , which mimics8 the body's natural process of monitoring and responding to glucose levels in the bloodstream.

"Physical activity enhances insulin action, hence lowering blood glucose concentration," Dr. Kudva says. "Real-time detection of physical activity -- and modeling of its effect on glucose dynamics9 -- is vital to design an automatic insulin delivery system."

Dr. Kudva and other Mayo researchers have spent nearly 15 years working on various aspects of diabetes and obesity10 (http://www.mayoclinic.com/health/obesity/DS00314). They are collaborating11 on the artificial pancreas and developing an algorithm that will afford patients the peace of mind to eliminate their daily routine of diabetes maintenance(维护,保持) .

Dr. Basu will present findings that blood sugar levels decrease faster in the mornings in healthy adults than at dinner time, suggesting a diurnal12(白天的) pattern to natural insulin action. He proposes further study of this phenomenon and possible incorporation13 into the algorithm that drives the Closed Loop System.



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1 diabetes uPnzu     
n.糖尿病
参考例句:
  • In case of diabetes, physicians advise against the use of sugar.对于糖尿病患者,医生告诫他们不要吃糖。
  • Diabetes is caused by a fault in the insulin production of the body.糖尿病是由体內胰岛素分泌失调引起的。
2 pricks 20f8a636f609ce805ce271cee734ba10     
刺痛( prick的名词复数 ); 刺孔; 刺痕; 植物的刺
参考例句:
  • My skin pricks sometimes. 我的皮肤有时感到刺痛。
  • You must obey the rule. It is useless for you to kick against the pricks. 你必须遵守规定,对抗对你是无益的。
3 mundane F6NzJ     
adj.平凡的;尘世的;宇宙的
参考例句:
  • I hope I can get an interesting job and not something mundane.我希望我可以得到的是一份有趣的工作,而不是一份平凡无奇的。
  • I find it humorous sometimes that even the most mundane occurrences can have an impact on our awareness.我发现生活有时挺诙谐的,即使是最平凡的事情也能影响我们的感知。
4 mimicking ac830827d20b6bf079d24a8a6d4a02ed     
v.(尤指为了逗乐而)模仿( mimic的现在分词 );酷似
参考例句:
  • She's always mimicking the teachers. 她总喜欢模仿老师的言谈举止。
  • The boy made us all laugh by mimicking the teacher's voice. 这男孩模仿老师的声音,逗得我们大家都笑了。 来自辞典例句
5 glucose Fyiyz     
n.葡萄糖
参考例句:
  • I gave him an extra dose of glucose to pep him up.我给他多注射了一剂葡萄糖以增强他的活力。
  • The doctor injected glucose into his patient's veins.医生将葡萄糖注入病人的静脉。
6 phenomena 8N9xp     
n.现象
参考例句:
  • Ade couldn't relate the phenomena with any theory he knew.艾德无法用他所知道的任何理论来解释这种现象。
  • The object of these experiments was to find the connection,if any,between the two phenomena.这些实验的目的就是探索这两种现象之间的联系,如果存在着任何联系的话。
7 fully Gfuzd     
adv.完全地,全部地,彻底地;充分地
参考例句:
  • The doctor asked me to breathe in,then to breathe out fully.医生让我先吸气,然后全部呼出。
  • They soon became fully integrated into the local community.他们很快就完全融入了当地人的圈子。
8 mimics f8207fb5fa948f536c5186311e3e641d     
n.模仿名人言行的娱乐演员,滑稽剧演员( mimic的名词复数 );善于模仿的人或物v.(尤指为了逗乐而)模仿( mimic的第三人称单数 );酷似
参考例句:
  • Methods:Models were generate by CT scan,Mimics software and Abaqus software. 方法:采用CT扫描,Mimics软件和Abaqus软件的CAD进行三维有限元模型的创建。 来自互联网
  • Relaxing the mind and body mimics the effect that some blood-pressure pills would have. 放松身心会产生某些降压药才能产生的效果。 来自辞典例句
9 dynamics NuSzQq     
n.力学,动力学,动力,原动力;动态
参考例句:
  • In order to succeed,you must master complicated knowledge of dynamics.要取得胜利,你必须掌握很复杂的动力学知识。
  • Dynamics is a discipline that cannot be mastered without extensive practice.动力学是一门不做大量习题就不能掌握的学科。
10 obesity Dv1ya     
n.肥胖,肥大
参考例句:
  • One effect of overeating may be obesity.吃得过多能导致肥胖。
  • Sugar and fat can more easily lead to obesity than some other foods.糖和脂肪比其他食物更容易导致肥胖。
11 collaborating bd93aed5558c4b146fa553d822f7c432     
合作( collaborate的现在分词 ); 勾结叛国
参考例句:
  • Joe is collaborating on the work with a friend. 乔正与一位朋友合作做那件工作。
  • He was not only learning from but also collaborating with Joseph Thomson. 他不仅是在跟约瑟福?汤姆逊学习,而且也是在和他合作。
12 diurnal ws5xi     
adj.白天的,每日的
参考例句:
  • Kangaroos are diurnal animals.袋鼠是日间活动的动物。
  • Over water the diurnal change in refraction is likely to be small. 在水面上,折光的周日变化可能是很小的。
13 incorporation bq7z8F     
n.设立,合并,法人组织
参考例句:
  • The incorporation of air bubbles in the glass spoiled it.玻璃含有气泡,使它质量降低。
  • The company will be retooled after the incorporation.合并之后的公司要进行重组。
TAG标签: diabetes insulin pancreas
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