人类味觉细胞可在培养皿中再生
文章来源:未知 文章作者:enread 发布时间:2011-04-07 02:58 字体: [ ]  进入论坛
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Following years of futile1(无用的) attempts, new research from the Monell Center demonstrates that living human taste cells can be maintained in culture for at least seven months. The findings provide scientists with a valuable tool to learn about the human sense of taste and how it functions in health and disease. This advance ultimately will assist efforts to prevent and treat taste loss or impairment due to infection, radiation, chemotherapy and chemical exposures.

"People who undergo chemotherapy or radiation therapy for oral cancer often lose their sense of taste, leading to decreased interest in food, weight loss, and malnutrition," said lead author M. Hakan Ozdener, M.D., Ph.D., M.P.H., a cellular2 biologist at Monell. "The success of this technique should provide hope for these people, as it finally provides us with a way to test drugs to promote recovery."

Taste cells are found in papillae, the little bumps on our tongues. These cells contain the receptors that interact with chemicals in foods to allow us to sense sweet, salty, sour, bitter, and umami(鲜味) . They also are among the few cells in the body with the special capacity to regenerate3, with new taste cells maturing from progenitor4(祖先,原著) 'stem' cells every 10-14 days.

For many years it was believed that taste cells needed to be attached to nerves in order to both function properly and regenerate. For this reason, scientists thought that it was not possible to isolate5 and grow these cells in culture, which limited the scope of studies to understand how human taste cells function.

"It had become engrained in the collective consciousness that it wouldn't work," said Monell cellular biologist Nancy E. Rawson, Ph.D

To dispel6 the long-held belief, the Monell scientists first demonstrated in 2006 that taste cells from rats could successfully be maintained in culture. In the current study, published online in the journal Chemical Senses, they then applied7 that methodology to a more clinically relevant population – humans.

Taking tiny samples of tongue tissue from human volunteers, the researchers first adapted existing techniques to demonstrate that the human taste cells indeed can regenerate in culture.

They went on to show that the new taste cells were functional8, maintaining key molecular9 and physiological10 properties characteristic of the parent cells. For example, the new cells also were activated12 by sweet and bitter taste molecules13.

"By producing new taste cells outside the body, our results demonstrate that direct stimulation14 from nerves is not necessary to generate functional taste cells from precursors," said Ozdener.

The establishment of a feasible long-term taste cell culture model opens a range of opportunities to increase understanding of the sense of taste.

"Results from these cells are more likely to translate to the clinic than those obtained from other species or from systems not derived15 from taste tissue," said Rawson.

The cells also can be used to screen and identify molecules that activate11 the taste receptors; one such example might be a salt replacer or enhancer.

"The model will help scientists identify new approaches to design and establish cell culture models for other human cells that previously had resisted viable culture conditions," said Ozdener



点击收听单词发音收听单词发音  

1 futile vfTz2     
adj.无效的,无用的,无希望的
参考例句:
  • They were killed,to the last man,in a futile attack.因为进攻失败,他们全部被杀,无一幸免。
  • Their efforts to revive him were futile.他们对他抢救无效。
2 cellular aU1yo     
adj.移动的;细胞的,由细胞组成的
参考例句:
  • She has a cellular telephone in her car.她的汽车里有一部无线通讯电话机。
  • Many people use cellular materials as sensitive elements in hygrometers.很多人用蜂窝状的材料作为测量温度的传感元件。
3 regenerate EU2xV     
vt.使恢复,使新生;vi.恢复,再生;adj.恢复的
参考例句:
  • Their aim is to regenerate British industry.他们的目的是复兴英国的工业。
  • Although it is not easy,you have the power to regenerate your life.尽管这不容易,但你有使生活重获新生的能力。
4 progenitor 2iiyD     
n.祖先,先驱
参考例句:
  • He was also a progenitor of seven presidents of Nicaragua.他也是尼加拉瓜7任总统的祖先。
  • Schoenberg was a progenitor of modern music.勋伯格是一位现代音乐的先驱。
5 isolate G3Exu     
vt.使孤立,隔离
参考例句:
  • Do not isolate yourself from others.不要把自己孤立起来。
  • We should never isolate ourselves from the masses.我们永远不能脱离群众。
6 dispel XtQx0     
vt.驱走,驱散,消除
参考例句:
  • I tried in vain to dispel her misgivings.我试图消除她的疑虑,但没有成功。
  • We hope the programme will dispel certain misconceptions about the disease.我们希望这个节目能消除对这种疾病的一些误解。
7 applied Tz2zXA     
adj.应用的;v.应用,适用
参考例句:
  • She plans to take a course in applied linguistics.她打算学习应用语言学课程。
  • This cream is best applied to the face at night.这种乳霜最好晚上擦脸用。
8 functional 5hMxa     
adj.为实用而设计的,具备功能的,起作用的
参考例句:
  • The telephone was out of order,but is functional now.电话刚才坏了,但现在可以用了。
  • The furniture is not fancy,just functional.这些家具不是摆着好看的,只是为了实用。
9 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
10 physiological aAvyK     
adj.生理学的,生理学上的
参考例句:
  • He bought a physiological book.他买了一本生理学方面的书。
  • Every individual has a physiological requirement for each nutrient.每个人对每种营养成分都有一种生理上的需要。
11 activate UJ2y0     
vt.使活动起来,使开始起作用
参考例句:
  • We must activate the youth to study.我们要激励青年去学习。
  • These push buttons can activate the elevator.这些按钮能启动电梯。
12 activated c3905c37f4127686d512a7665206852e     
adj. 激活的 动词activate的过去式和过去分词
参考例句:
  • The canister is filled with activated charcoal.蒸气回收罐中充满了活性炭。
13 molecules 187c25e49d45ad10b2f266c1fa7a8d49     
分子( molecule的名词复数 )
参考例句:
  • The structure of molecules can be seen under an electron microscope. 分子的结构可在电子显微镜下观察到。
  • Inside the reactor the large molecules are cracked into smaller molecules. 在反应堆里,大分子裂变为小分子。
14 stimulation BuIwL     
n.刺激,激励,鼓舞
参考例句:
  • The playgroup provides plenty of stimulation for the children.幼儿游戏组给孩子很多启发。
  • You don't get any intellectual stimulation in this job.你不能从这份工作中获得任何智力启发。
15 derived 6cddb7353e699051a384686b6b3ff1e2     
vi.起源;由来;衍生;导出v.得到( derive的过去式和过去分词 );(从…中)得到获得;源于;(从…中)提取
参考例句:
  • Many English words are derived from Latin and Greek. 英语很多词源出于拉丁文和希腊文。 来自《简明英汉词典》
  • He derived his enthusiasm for literature from his father. 他对文学的爱好是受他父亲的影响。 来自《简明英汉词典》
TAG标签: taste cells human
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