In an advance that could improve battlefield and trauma¹ care, scientists at Albert Einstein College of Medicine of Yeshiva University have used tiny particles called nanoparticles to improve survival after life-threatening blood loss. Nanoparticles containing nitric oxide² (NO) were infused（灌输） into the bloodstream of hamsters（仓鼠） , where they helped maintain blood circulation and protect vital organs. The research was reported in the February 21 online edition of the journal Resuscitation³. "The new nanomedicine was developed to address the need for better field treatments for massive human blood loss, which can cause cardiovascular collapse⁴, also known as hemorrhagic（出血的） shock. This potentially fatal condition is best treated with infusions⁵ of refrigerated blood and other fluids. But such treatments are limited to emergency rooms or trauma centers.

"It is highly impractical⁶ to pack these supplies for use in rural emergencies, mass-casualty disasters or on the battlefield," said coauthor Joel Friedman, M.D., Ph.D., professor of physiology⁷ & medicine and of medicine and the Young Men's Division Chair in Physiology at Einstein. "Our nanoparticle therapy may offer the potential for saving lives in those situations. It's lightweight and compact and doesn't require refrigeration."

The new therapy counters hemorrhagic shock by increasing the body's levels of NO gas, which, among other physiological⁸ functions, relaxes blood vessels⁹ and regulates blood pressure. The gas was encased in microscopic-sized particles that were specially¹⁰ designed by the Einstein team. (NO is so short-lived that delivering it in therapeutic¹¹ amounts requires a method of sustained release.) The therapy is created by adding the NO-containing nanoparticles to saline（盐） solution, which was then infused into the animals. Once in the body, the nanoparticles gradually release a sustained dose of NO to tissues.

The nanomedicine was successfully tested in hamsters that had lost half their blood volume. "Animals given the nanoparticles exhibited better cardiac stability, stronger blood flow to tissues and other measures of hemorrhagic shock recovery compared to controls receiving saline solution minus the nanoparticles," reported Dr. Friedman.

Previously¹² published studies by Dr. Friedman and colleagues have demonstrated the beneficial effects of NO-containing nanoparticles for healing antibiotic-resistant staph（葡萄球菌） infections and abscess（脓肿） caused by those bacteria and for treating erectile dysfunction.