文章来源:未知 文章作者:meng 发布时间:2010-12-27 03:42 字体: [ ]  进入论坛

A study was carried out to examine the extent to which quercetin(槲皮黄酮) and trans-resveratrol (RSV) prevented inflammation or insulin resistance in primary cultures of human adipocytes(脂肪细胞) treated with tumor1 necrosis(坏死,坏疽) factor-a (TNF-a)—an inflammatory cytokine(细胞因子) elevated in the plasma2 and adipose3 tissue(脂肪组织) of obese4, diabetic individuals. Cultures of human adipocytes were pretreated with quercetin and trans-RSV followed by treatment with TNF-a. Subsequently, gene5 and protein markers of inflammation and insulin resistance were measured. The authors report that quercetin, and to a lesser6 extent trans-RSV, attenuated7 the TNF-a–induced expression of inflammatory genes8 such as interleukin (IL)-6, IL-1b, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion9 of IL-6, IL-8, and MCP-1. Forum10 members were concerned about certain aspects of the study, especially the extrapolation(外推法) of in vitro results to in vivo situations. The in vitro conditions the authors describe are minimally11 representative of an in vivo condition. In vivo, after consumption of quercetin or resveratrol, these compounds undergo extensive metabolism12, leading to glucuronidated, sulphated(硫酸盐) or methylated compounds. In a previous study, quercetin 3-glucoside was transformed to 3,4-dihydroxyphenylacetic acid, acetate and butyrate in cells from human gut13; only 3'-methylquercetin has been detected in human plasma, present at a concentration of 0.1 to 0.2 µM after 3 h. The authors of the current paper are using concentrations up to 60 µM, concentrations which have not been found in vivo(在活体内) .

There were also concerns with the work on cell uptake of quercetin and resveratrol. Primary adipocytes were incubated with the polyphenols, but it is not clear whether or not the concentrations used were subtoxic. Our current knowledge is limited about local concentration of the molecules14 we are studying in subcellular compartments15, their interaction with alternative targets, and eventually their transformation16 into products that could be more or less active on a given specific pathway. The real difficult and important issue is the identification of a reasonable convergence(收敛,会聚) -- if not agreement -- between data originating from extremely distant approaches. In this case, the notion that metabolic17 diseases are related to a homeostatic imbalance in adipose tissue, linked to a different redox status, linked to activation18 of specific pathways, and that different redox(氧化还原反应) sensitive polyphenols(多酚类) do have a protective effect, encompasses19 the evidence produced by extremely distant approaches.

From a clinical point of view, the role of phytochemicals acting20 as antioxidants and anti-inflammatory agents could be extremely important in inflammation-associated chronic21 conditions such as cardiovascular disease, diabetes22, and cancer. Quercetin and resveratrol may indeed play an important role in this regard, and need to be investigated further to establish the clinical importance of natural dietary compounds in the prevention of chronic degenerative conditions.


1 tumor fKxzm     
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
2 plasma z2xzC     
  • Keep some blood plasma back for the serious cases.留一些血浆给重病号。
  • The plasma is the liquid portion of blood that is free of cells .血浆是血液的液体部分,不包含各种细胞。
3 adipose cJayQ     
  • After I become pouch operation adipose meeting second birth?我做眼袋手术后脂肪会再生吗?
  • Adipose tissue as seen in a regular histological section.组织切片可见脂肪组织。
4 obese uvIya     
  • The old man is really obese,it can't be healthy.那位老人确实过于肥胖了,不能算是健康。
  • Being obese and lazy is dangerous to health.又胖又懒危害健康。
5 gene WgKxx     
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
6 lesser UpxzJL     
  • Kept some of the lesser players out.不让那些次要的球员参加联赛。
  • She has also been affected,but to a lesser degree.她也受到波及,但程度较轻。
7 attenuated d547804f5ac8a605def5470fdb566b22     
v.(使)变细( attenuate的过去式和过去分词 );(使)变薄;(使)变小;减弱
  • an attenuated form of the virus 毒性已衰减的病毒
  • You're a seraphic suggestion of attenuated thought . 你的思想是轻灵得如同天使一般的。 来自辞典例句
8 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
9 secretion QDozG     
  • Is there much secretion from your eyes?你眼里的分泌物多吗?
  • In addition,excessive secretion of oil,water scarcity are also major factors.除此之外,油脂分泌过盛、缺水也都是主要因素。
10 forum cilx0     
  • They're holding a forum on new ways of teaching history.他们正在举行历史教学讨论会。
  • The organisation would provide a forum where problems could be discussed.这个组织将提供一个可以讨论问题的平台。
11 minimally 0e3844f43172f471e75a897f7b3116da     
  • Food spoilage problems occur with minimally processed, concentrated frozen citrus products. 食品的变质也发生在轻微加工的、浓缩冷冻的柑橘制品中。
  • So, minimally, they are responsible for such actions and omissions. 所以,至少来说,他们要对这样的行为和忽略负责。
12 metabolism 171zC     
  • After years of dieting,Carol's metabolism was completely out of whack.经过数年的节食,卡罗尔的新陈代谢完全紊乱了。
  • All living matter undergoes a process of metabolism.生物都有新陈代谢。
13 gut MezzP     
  • It is not always necessary to gut the fish prior to freezing.冷冻鱼之前并不总是需要先把内脏掏空。
  • My immediate gut feeling was to refuse.我本能的直接反应是拒绝。
14 molecules 187c25e49d45ad10b2f266c1fa7a8d49     
分子( molecule的名词复数 )
  • The structure of molecules can be seen under an electron microscope. 分子的结构可在电子显微镜下观察到。
  • Inside the reactor the large molecules are cracked into smaller molecules. 在反应堆里,大分子裂变为小分子。
15 compartments 4e9d78104c402c263f5154f3360372c7     
n.间隔( compartment的名词复数 );(列车车厢的)隔间;(家具或设备等的)分隔间;隔层
  • Your pencil box has several compartments. 你的铅笔盒有好几个格。 来自《简明英汉词典》
  • The first-class compartments are in front. 头等车室在前头。 来自《简明英汉词典》
16 transformation SnFwO     
  • Going to college brought about a dramatic transformation in her outlook.上大学使她的观念发生了巨大的变化。
  • He was struggling to make the transformation from single man to responsible husband.他正在努力使自己由单身汉变为可靠的丈夫。
17 metabolic 2R4z1     
  • Impressive metabolic alternations have been undergone during embryogenesis.在胚胎发生期间经历了深刻的代谢变化。
  • A number of intoxicants are associated with metabolic acidosis.许多毒性物质可引起代谢性酸中毒。
18 activation 24eed33ee38027d124839f0fcdf6adcb     
n. 激活,催化作用
  • A computer controls the activation of an air bag.电脑控制着气囊的启动。
19 encompasses cba8673f835839b92e7b81ba5bccacfb     
v.围绕( encompass的第三人称单数 );包围;包含;包括
  • The job encompasses a wide range of responsibilities. 这项工作涉及的职责范围很广。
  • Its conservation law encompasses both its magnitude and its direction. 它的守恒定律包括大小和方向两方面。 来自辞典例句
20 acting czRzoc     
  • Ignore her,she's just acting.别理她,她只是假装的。
  • During the seventies,her acting career was in eclipse.在七十年代,她的表演生涯黯然失色。
21 chronic BO9zl     
  • Famine differs from chronic malnutrition.饥荒不同于慢性营养不良。
  • Chronic poisoning may lead to death from inanition.慢性中毒也可能由虚弱导致死亡。
22 diabetes uPnzu     
  • In case of diabetes, physicians advise against the use of sugar.对于糖尿病患者,医生告诫他们不要吃糖。
  • Diabetes is caused by a fault in the insulin production of the body.糖尿病是由体內胰岛素分泌失调引起的。
TAG标签: human protein tumor insulin