文章来源:未知 文章作者:meng 发布时间:2010-10-31 03:15 字体: [ ]  进入论坛

Scientists of the Max Delbrück Center for Molecular1 Medicine (MDC) Berlin-Buch and the Experimental and Clinical Research Center (ECRC) of MDC and Charité in Berlin-Buch have gained new insights into the development of epithelial cells(上皮细胞) and their molecular repertoire2(全部节目) . Dr. Max Werth, Katharina Walentin and Professor Kai Schmidt-Ott have identified a transcription factor (grainyhead-like 2, Grhl2), which regulates the composition of the molecular "bridges" that link adjacent(临近的,毗邻的) epithelial cells. The authors were able to demonstrate that Grhl2, via DNA-binding, directly regulates the expression of two such cell junctional molecules3, E-cadherin and claudin 4 (Development, doi:10.1242/dev.055483). This could be important for understanding the mechanisms4 of various diseases. For example, Grhl2-deficient mice die early in embryonic5 development and display defects of neural6 tube closure, including spina bifida(脊柱裂) .

Spina bifida is a common human congenital disease(先天性疾病) that is often associated with severe disabilities. Little is known about how the disease develops, and Grhl2 may be an important player in its pathogenesis(发病机理) .

Furthermore, the authors hypothesize that Grhl2 may also have important functions in internal organs, such as the kidney. Epithelial cells line the renal(肾脏的) tubular(管状的) system, which in humans is several kilometers long.

This system of renal tubules, together with the renal corpuscles(肾小体) , forms the basic structural7 and functional8 unit of the kidney – the nephron(肾元) . The human kidney filters waste products from 1700 liters of blood per day, of which 180 liters are collected as primary urine and of which finally one to two liters are excreted as urine.

The studies of the authors show that Grhl2 is produced in nephron segments that are relatively9 impermeable10(不渗透的) to water and solutes and that fine-tune the composition of urine.

A dysfunction of Grhl2 in these cells may affect epithelial barrier formation and other cell characteristics and, thereby11, contribute to various diseases, including congenital abnormalities(畸形,机场情况) of the kidney or the development of hypertension.


1 molecular mE9xh     
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
2 repertoire 2BCze     
n.(准备好演出的)节目,保留剧目;(计算机的)指令表,指令系统, <美>(某个人的)全部技能;清单,指令表
  • There is an extensive repertoire of music written for the flute.有很多供长笛演奏的曲目。
  • He has added considerably to his piano repertoire.他的钢琴演奏曲目大大增加了。
3 molecules 187c25e49d45ad10b2f266c1fa7a8d49     
分子( molecule的名词复数 )
  • The structure of molecules can be seen under an electron microscope. 分子的结构可在电子显微镜下观察到。
  • Inside the reactor the large molecules are cracked into smaller molecules. 在反应堆里,大分子裂变为小分子。
4 mechanisms d0db71d70348ef1c49f05f59097917b8     
n.机械( mechanism的名词复数 );机械装置;[生物学] 机制;机械作用
  • The research will provide direct insight into molecular mechanisms. 这项研究将使人能够直接地了解分子的机理。 来自《简明英汉词典》
  • He explained how the two mechanisms worked. 他解释这两台机械装置是如何工作的。 来自《简明英汉词典》
5 embryonic 58EyK     
  • It is still in an embryonic stage.它还处于萌芽阶段。
  • The plan,as yet,only exists in embryonic form.这个计划迄今为止还只是在酝酿之中。
6 neural DnXzFt     
  • The neural network can preferably solve the non- linear problem.利用神经网络建模可以较好地解决非线性问题。
  • The information transmission in neural system depends on neurotransmitters.信息传递的神经途径有赖于神经递质。
7 structural itXw5     
  • The storm caused no structural damage.风暴没有造成建筑结构方面的破坏。
  • The North American continent is made up of three great structural entities.北美大陆是由三个构造单元组成的。
8 functional 5hMxa     
  • The telephone was out of order,but is functional now.电话刚才坏了,但现在可以用了。
  • The furniture is not fancy,just functional.这些家具不是摆着好看的,只是为了实用。
9 relatively bkqzS3     
  • The rabbit is a relatively recent introduction in Australia.兔子是相对较新引入澳大利亚的物种。
  • The operation was relatively painless.手术相对来说不痛。
10 impermeable x43yk     
  • The canoe is made from an impermeable wood.独木舟由防水木头制成。
  • The external layer of the skin is relatively impermeable to water.皮肤的外层不透水。
11 thereby Sokwv     
  • I have never been to that city,,ereby I don't know much about it.我从未去过那座城市,因此对它不怎么熟悉。
  • He became a British citizen,thereby gaining the right to vote.他成了英国公民,因而得到了投票权。
TAG标签: cells molecular epithelial