生物合成角膜或将恢复人类视力
文章来源:未知 文章作者:meng 发布时间:2010-08-26 02:22 字体: [ ]  进入论坛
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A new study from researchers in Canada and Sweden has shown that biosynthetic(生物合成的) corneas(角膜) can help regenerate1 and repair damaged eye tissue and improve vision in humans. The results, from an early phase clinical trial with 10 patients, are published in the August 25th, 2010 issue of Science Translational Medicine. "This study is important because it is the first to show that an artificially fabricated(焊接的,组合的) cornea can integrate with the human eye and stimulate2 regeneration," said senior author Dr. May Griffith of the Ottawa Hospital Research Institute, the University of Ottawa and Linköping University. "With further research, this approach could help restore sight to millions of people who are waiting for a donated human cornea for transplantation."

The cornea is a thin transparent3 layer of collagen(胶原) and cells that acts as a window into the eyeball. It must be completely transparent to allow the light to enter and it also helps with focus. Globally, diseases that lead to clouding of the cornea represent the most common cause of blindness. More than a decade ago, Dr. Griffith and her colleagues began developing biosynthetic corneas in Ottawa, Canada, using collagen produced in the laboratory and moulded into the shape of a cornea. After extensive laboratory testing, Dr. Griffith began collaborating4 with Dr. Per Fagerholm, an eye surgeon at Linköping University in Sweden, to provide the first-in-human experience with biosynthetic cornea implantation.

Together, they initiated6 a clinical trial in 10 Swedish patients with advanced keratoconus(圆锥形角膜) or central corneal scarring. Each patient underwent surgery on one eye to remove damaged corneal tissue and replace it with the biosynthetic cornea, made from synthetically7 cross-linked recombinant(重组) human collagen. Over two years of follow-up, the researchers observed that cells and nerves from the patients' own corneas had grown into the implant5, resulting in a "regenerated8" cornea that resembled normal, healthy tissue. Patients did not experience any rejection9 reaction or require long-term immune suppression, which are serious side effects associated with the use of human donor10 tissue. The biosynthetic corneas also became sensitive to touch and began producing normal tears to keep the eye oxygenated. Vision improved in six of the ten patients, and after contact lens fitting, vision was comparable to conventional corneal transplantation with human donor tissue.

"We are very encouraged by these results and by the great potential of biosynthetic corneas," said Dr. Fagerholm. "Further biomaterial enhancements and modifications11 to the surgical12 technique are ongoing13, and new studies are being planned that will extend the use of the biosynthetic cornea to a wider range of sight-threatening conditions requiring transplantation."



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1 regenerate EU2xV     
vt.使恢复,使新生;vi.恢复,再生;adj.恢复的
参考例句:
  • Their aim is to regenerate British industry.他们的目的是复兴英国的工业。
  • Although it is not easy,you have the power to regenerate your life.尽管这不容易,但你有使生活重获新生的能力。
2 stimulate wuSwL     
vt.刺激,使兴奋;激励,使…振奋
参考例句:
  • Your encouragement will stimulate me to further efforts.你的鼓励会激发我进一步努力。
  • Success will stimulate the people for fresh efforts.成功能鼓舞人们去作新的努力。
3 transparent Smhwx     
adj.明显的,无疑的;透明的
参考例句:
  • The water is so transparent that we can see the fishes swimming.水清澈透明,可以看到鱼儿游来游去。
  • The window glass is transparent.窗玻璃是透明的。
4 collaborating bd93aed5558c4b146fa553d822f7c432     
合作( collaborate的现在分词 ); 勾结叛国
参考例句:
  • Joe is collaborating on the work with a friend. 乔正与一位朋友合作做那件工作。
  • He was not only learning from but also collaborating with Joseph Thomson. 他不仅是在跟约瑟福?汤姆逊学习,而且也是在和他合作。
5 implant YaBxT     
vt.注入,植入,灌输
参考例句:
  • A good teacher should implant high ideals in children.好教师应该把高尚理想灌输给孩子们。
  • The operation to implant the artificial heart took two hours.人工心脏植入手术花费了两小时。
6 initiated 9cd5622f36ab9090359c3cf3ca4ddda3     
n. 创始人 adj. 新加入的 vt. 开始,创始,启蒙,介绍加入
参考例句:
  • He has not yet been thoroughly initiated into the mysteries of computers. 他对计算机的奥秘尚未入门。
  • The artist initiated the girl into the art world in France. 这个艺术家介绍这个女孩加入巴黎艺术界。
7 synthetically a15ece361e9a5289112dfbb9319bf772     
adv. 综合地,合成地
参考例句:
  • The time sequence model synthetically reflects trends of groundwater level. 总体来说,季节性时序模型的模拟和预测精度较高。
  • You can't do It'synthetically, by just flying around and dropping in. 你不能仅靠坐着飞机到处蜻蜓点水地看看就得出一个综合印象。
8 regenerated 67df9da7e5af2af5acd8771deef0296f     
v.新生,再生( regenerate的过去式和过去分词 )
参考例句:
  • They are regarded as being enveloped in regenerated gneisses. 它们被认为包围在再生的片麻岩之中。 来自辞典例句
  • The party soon regenerated under her leadership. 该党在她的领导下很快焕然一新。 来自辞典例句
9 rejection FVpxp     
n.拒绝,被拒,抛弃,被弃
参考例句:
  • He decided not to approach her for fear of rejection.他因怕遭拒绝决定不再去找她。
  • The rejection plunged her into the dark depths of despair.遭到拒绝使她陷入了绝望的深渊。
10 donor dstxI     
n.捐献者;赠送人;(组织、器官等的)供体
参考例句:
  • In these cases,the recipient usually takes care of the donor afterwards.在这类情况下,接受捐献者以后通常会照顾捐赠者。
  • The Doctor transplanted the donor's heart to Mike's chest cavity.医生将捐赠者的心脏移植进麦克的胸腔。
11 modifications aab0760046b3cea52940f1668245e65d     
n.缓和( modification的名词复数 );限制;更改;改变
参考例句:
  • The engine was pulled apart for modifications and then reassembled. 发动机被拆开改型,然后再组装起来。 来自《简明英汉词典》
  • The original plan had undergone fairly extensive modifications. 原计划已经作了相当大的修改。 来自《简明英汉词典》
12 surgical 0hXzV3     
adj.外科的,外科医生的,手术上的
参考例句:
  • He performs the surgical operations at the Red Cross Hospital.他在红十字会医院做外科手术。
  • All surgical instruments must be sterilised before use.所有的外科手术器械在使用之前,必须消毒。
13 ongoing 6RvzT     
adj.进行中的,前进的
参考例句:
  • The problem is ongoing.这个问题尚未解决。
  • The issues raised in the report relate directly to Age Concern's ongoing work in this area.报告中提出的问题与“关心老人”组织在这方面正在做的工作有直接的关系。
TAG标签: human eye vision corneas
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