文章来源:未知 文章作者:meng 发布时间:2010-06-01 01:50 字体: [ ]  进入论坛

Scientists at the University of California, San Diego have identified a previously1 unknown kinase(激酶,致活酶) that regulates cell proliferation(增殖,扩散) , shape and migration2, and may play a major role in the progression or metastasis(转移,新陈代谢) of cancer cells. The research will be published in the May 31 online Early Edition of the Proceedings3 of the National Academy of Sciences.

Richard L. Klemke, PhD, professor of pathology(病理学) at the UCSD School of Medicine and the Moores Cancer Center, and colleagues say the new kinase or enzyme4 regulates the cytoskeleton(细胞骨架) – the internal framework of tiny filaments5(花丝,灯丝) and microtubules in cells that gives them shape, coherence6 and the ability to move.

"This molecule7 may be an important new target for future anticancer therapies and a clinical biomarker that predicts whether a cancer is likely to spread," said Klemke.

Proper regulation of the cytoskeleton is important to many fundamental cellular8 functions, including axon/dendrite formation, migration, differentiation9 and proliferation. Conversely, deregulation of the cytoskeleton can contribute to a variety of human diseases, including cancer metastasis or the spread of tumors to other parts of the body.

The new kinase – called pseudopodium(虚足,假足) -enriched atypical kinase one or PEAK1 – plays a central role in the formation of cellular pseudopodia(伪足) . Greek for "false foot," a pseudopodium is a highly specialized11 structure that protrudes12 from the surface of migrating cells. It attaches the leading, extending membrane13 of the cell to its underlying14 substrate(基质,底片) , and then helps pull the cell forward. By endlessly repeating this process, a cell is able to move in a productive manner.

"Cancer cells capitalize on their innate15 ability to move in this fashion when they metastasize," said Jonathan A. Kelber, PhD, leading author on the paper and postdoctoral fellow in Klemke's lab. "Cancer cells detach from(分离,拆卸) the primary tumor10, invade the extracellular(细胞外的) milieu16(环境,周围) and then enter the vascular17 system(血管系统) from which they can spread and seed new tumors in distant tissues."

Discovering PEAK1 provides researchers with a new player to study and investigate, one that may have significant influence in the biology of cells, particularly cancer cells. Evidence from mouse studies suggests PEAK1 is an important player during tumor growth, and Klemke's team has further demonstrated that PEAK1 levels are increased in primary and metastatic samples from human colon18 cancer patients. Whether PEAK1 is capable of transforming non-tumor cells into cancer cells remains19 to be determined20.

"One exciting fact is that PEAK1 has kinase activity, which suggests you can design a small molecule drug that would specifically inhibit21 its activity," said Kelber. "But that work lies in the future. First, we need to fully22 identify the role of its kinase domain23 in tumor progression."


1 previously bkzzzC     
  • The bicycle tyre blew out at a previously damaged point.自行车胎在以前损坏过的地方又爆开了。
  • Let me digress for a moment and explain what had happened previously.让我岔开一会儿,解释原先发生了什么。
2 migration mDpxj     
  • Swallows begin their migration south in autumn.燕子在秋季开始向南方迁移。
  • He described the vernal migration of birds in detail.他详细地描述了鸟的春季移居。
3 proceedings Wk2zvX     
  • He was released on bail pending committal proceedings. 他交保获释正在候审。
  • to initiate legal proceedings against sb 对某人提起诉讼
4 enzyme cPozF     
  • Above a certain temperature,the enzyme molecule will become unfolded.超过一定温度,酶分子将会展开。
  • An enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
5 filaments 82be78199276cbe86e0e8b6c084015b6     
n.(电灯泡的)灯丝( filament的名词复数 );丝极;细丝;丝状物
  • Instead, sarcomere shortening occurs when the thin filaments'slide\" by the thick filaments. 此外,肌节的缩短发生于细肌丝沿粗肌丝“滑行”之际。 来自辞典例句
  • Wetting-force data on filaments of any diameter and shape can easily obtained. 各种直径和形状的长丝的润湿力数据是易于测量的。 来自辞典例句
6 coherence jWGy3     
  • There was no coherence between the first and the second half of the film.这部电影的前半部和后半部没有连贯性。
  • Environmental education is intended to give these topics more coherence.环境教育的目的是使这些课题更加息息相关。
7 molecule Y6Tzn     
  • A molecule of water is made up of two atoms of hygrogen and one atom of oxygen.一个水分子是由P妈?f婘??妈?成的。
  • This gives us the structural formula of the molecule.这种方式给出了分子的结构式。
8 cellular aU1yo     
  • She has a cellular telephone in her car.她的汽车里有一部无线通讯电话机。
  • Many people use cellular materials as sensitive elements in hygrometers.很多人用蜂窝状的材料作为测量温度的传感元件。
9 differentiation wuozfs     
  • There can be no differentiation without contrast. 有比较才有差别。
  • The operation that is the inverse of differentiation is called integration. 与微分相反的运算叫做积分。
10 tumor fKxzm     
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
11 specialized Chuzwe     
  • There are many specialized agencies in the United Nations.联合国有许多专门机构。
  • These tools are very specialized.这些是专用工具。
12 protrudes b9a9892d86d36fcc2b6624b1867a9d3e     
v.(使某物)伸出,(使某物)突出( protrude的第三人称单数 )
  • My part that protrudes from the gum has a'skin" of enamel. 在我突出于齿龈的部分有一层珐琅“皮”。 来自辞典例句
  • Hyperplasia median lobe of the prostate produces a polypoid mass that protrudes in the bladder lumen. 前列腺中叶异常增生,表现为息肉样肿物,突入膀胱腔内。 来自互联网
13 membrane H7ez8     
  • A vibrating membrane in the ear helps to convey sounds to the brain.耳膜的振动帮助声音传送到大脑。
  • A plastic membrane serves as selective diffusion barrier.一层塑料薄膜起着选择性渗透屏障的作用。
14 underlying 5fyz8c     
  • The underlying theme of the novel is very serious.小说隐含的主题是十分严肃的。
  • This word has its underlying meaning.这个单词有它潜在的含义。
15 innate xbxzC     
  • You obviously have an innate talent for music.你显然有天生的音乐才能。
  • Correct ideas are not innate in the mind.人的正确思想不是自己头脑中固有的。
16 milieu x7yzN     
  • Foods usually provide a good milieu for the persistence of viruses.食品通常为病毒存续提供了一个良好的栖身所。
  • He was born in a social milieu where further education was a luxury.他生在一个受较高教育就被认为是奢侈的社会环境里。
17 vascular cidw6     
  • The mechanism of this anomalous vascular response is unknown.此种不规则的血管反应的机制尚不清楚。
  • The vascular changes interfere with diffusion of nutrients from plasma into adjacent perivascular tissue and cells.这些血管变化干扰了营养物质从血浆中向血管周围邻接的组织和细胞扩散。
18 colon jqfzJ     
  • Here,too,the colon must be followed by a dash.这里也是一样,应当在冒号后加破折号。
  • The colon is the locus of a large concentration of bacteria.结肠是大浓度的细菌所在地。
19 remains 1kMzTy     
  • He ate the remains of food hungrily.他狼吞虎咽地吃剩余的食物。
  • The remains of the meal were fed to the dog.残羹剩饭喂狗了。
20 determined duszmP     
  • I have determined on going to Tibet after graduation.我已决定毕业后去西藏。
  • He determined to view the rooms behind the office.他决定查看一下办公室后面的房间。
21 inhibit C7jxT     
  • Don't let ego and greed inhibit clear thinking and hard work.不要让自我和贪婪妨碍清晰的思维和刻苦的工作。
  • They passed a law to inhibit people from parking in the street.他们通过一项法令以阻止人们在街上停车。
22 fully Gfuzd     
  • The doctor asked me to breathe in,then to breathe out fully.医生让我先吸气,然后全部呼出。
  • They soon became fully integrated into the local community.他们很快就完全融入了当地人的圈子。
23 domain ys8xC     
  • This information should be in the public domain.这一消息应该为公众所知。
  • This question comes into the domain of philosophy.这一问题属于哲学范畴。
TAG标签: cells cancer cell kinasa