文章来源:未知 文章作者:meng 发布时间:2010-04-01 02:34 字体: [ ]  进入论坛

Today's publication in Nature of the genetic1 blueprint2 for the zebra finch3(斑胸草雀) marks 10 years of success for the Ensembl project in helping4 researchers to navigate5 the genomes of a Noah's Ark of species. Ensembl, a genome annotation6(注释,注解) system co-developed and jointly8(共同地,连带地) run by the European Bioinformatics Institute (EMBL-EBI) and the Wellcome Trust Sanger Institute, played a major part in finding the genes9 and other functionally10 important features in the zebra finch genome. For zebra finch, only the second bird to have its genome fully11 sequenced after the chicken, this interpretation12 of the genetic code has enabled the sequencing consortium(财团,合伙) to identify genes expressed in the zebra finch brain that may be responsible for vocalising(发声) messages: zebra finches communicate by singing whereas(鉴于,反之) chickens cannot.

"Trying to navigate a genome that has not been annotated13(有注释的,带注解的) with important features such as genes and regulatory regions is a little bit like trying to read a map missing all the labels," explains Paul Flicek, joint7 head of Ensembl and leader of the Vertebrate Genomics team at EMBL-EBI. "Without this annotation, the data gathered from sequencing projects would remain undecipherable(难辨认的,破译不出的) ."

Ensembl, which was originally created as a means of cataloguing the genes in the human genome, now contains the complete genetic codes of more than 50 animals. In addition to zebra finch, Ensembl has unravelled14(阐明,解决) the genomes of organisms ranging in complexity15 from the humble16 nematode(线虫) worm through the duck billed platypus17(鸭嘴兽) to ourselves.

"Genome analysis and comparison is key to linking genes to function and explaining why species differ from each other," says Steve Searle, joint head of Ensembl and of Vertebrate Annotation at the Wellcome Trust Sanger Institute "In addition to helping us know more about evolutionary18 relationships and genetic diversity, it also provides the tools to tackle disease at the genetic level."

"Over 10 years Ensembl has become part of the infrastructure19 of biological research," says Tim Hubbard, Head of Informatics at the Wellcome Trust Sanger Institute. "Looking back it's hard to imagine research before genomes and genome browsers20."

Combining information held in Ensembl with the related Ensembl Genomes resource for the genomes of bacteria, fungi21(真菌) , plants, metazoa(后生动物,复细胞动物) and protists(原生动物) launched by EMBL-EBI last year, every sequenced genome provides another jigsaw22(线锯,镂花锯) piece in cataloguing the genetic diversity of life.


1 genetic PgIxp     
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
2 blueprint 6Rky6     
  • All the machine parts on a blueprint must answer each other.设计图上所有的机器部件都应互相配合。
  • The documents contain a blueprint for a nuclear device.文件内附有一张核装置的设计蓝图。
3 finch TkRxS     
  • This behaviour is commonly observed among several species of finch.这种行为常常可以在几种雀科鸣禽中看到。
  • In Australia,it is predominantly called the Gouldian Finch.在澳大利亚,它主要还是被称之为胡锦雀。
4 helping 2rGzDc     
  • The poor children regularly pony up for a second helping of my hamburger. 那些可怜的孩子们总是要求我把我的汉堡包再给他们一份。
  • By doing this, they may at times be helping to restore competition. 这样一来, 他在某些时候,有助于竞争的加强。
5 navigate 4Gyxu     
  • He was the first man to navigate the Atlantic by air.他是第一个飞越大西洋的人。
  • Such boats can navigate on the Nile.这种船可以在尼罗河上航行。
6 annotation 0V5zA     
  • She retained a number of copies for further annotation.她保留了许多副本以便作进一步的注解。
  • He supplied annotations to nearly 15,000 musical works.他给近1.5万部音乐作品作过注解。
7 joint m3lx4     
  • I had a bad fall,which put my shoulder out of joint.我重重地摔了一跤,肩膀脫臼了。
  • We wrote a letter in joint names.我们联名写了封信。
8 jointly jp9zvS     
  • Tenants are jointly and severally liable for payment of the rent. 租金由承租人共同且分别承担。
  • She owns the house jointly with her husband. 她和丈夫共同拥有这所房子。
9 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
10 functionally 07b8a8a682798862ca0c3d3a567f4c3d     
  • Objective To explore occlusion reconstruction by computer aided design (CAD) with functionally-generated pathway (FGP). 目的探索借助功能性?记录(functionally-generated pathway,FGP)技术进行口腔固定修复体计算机辅助设计(Computer aided Design,CAD)生理性建?的方法。 来自互联网
  • In this respect, the proceeding was functionally similar to a comparative licensing adjudication. 在这一点上,手续在作用上即类似于比较许可证发放的裁断。 来自英汉非文学 - 行政法
11 fully Gfuzd     
  • The doctor asked me to breathe in,then to breathe out fully.医生让我先吸气,然后全部呼出。
  • They soon became fully integrated into the local community.他们很快就完全融入了当地人的圈子。
12 interpretation P5jxQ     
  • His statement admits of one interpretation only.他的话只有一种解释。
  • Analysis and interpretation is a very personal thing.分析与说明是个很主观的事情。
13 annotated c2a54daf2659390553c9665593260606     
v.注解,注释( annotate的过去式和过去分词 )
  • Thematic maps should always be annotated with the source and date of the topical information. 各类专题地图,均应注明专题资料来源和日期。 来自辞典例句
  • And this is the version annotated by Umberto de Bologna. 并且这是有安博多-德-波罗格那注释的版本。 来自电影对白
14 unravelled 596c5e010a04f9867a027c09c744f685     
解开,拆散,散开( unravel的过去式和过去分词 ); 阐明; 澄清; 弄清楚
  • I unravelled the string and wound it into a ball. 我把绳子解开并绕成一个球。
  • The legal tangle was never really unravelled. 这起法律纠葛从来没有真正解决。
15 complexity KO9z3     
  • Only now did he understand the full complexity of the problem.直到现在他才明白这一问题的全部复杂性。
  • The complexity of the road map puzzled me.错综复杂的公路图把我搞糊涂了。
16 humble ddjzU     
  • In my humble opinion,he will win the election.依我拙见,他将在选举中获胜。
  • Defeat and failure make people humble.挫折与失败会使人谦卑。
17 platypus 4Obxs     
  • The platypus spends a great deal of its time looking for food. 鸭嘴兽要用大量的时间去觅食。
  • One of the mascots was the platypus.吉祥物之一是鸭嘴兽。
18 evolutionary Ctqz7m     
  • Life has its own evolutionary process.生命有其自身的进化过程。
  • These are fascinating questions to be resolved by the evolutionary studies of plants.这些十分吸引人的问题将在研究植物进化过程中得以解决。
19 infrastructure UbBz5     
  • We should step up the development of infrastructure for research.加强科学基础设施建设。
  • We should strengthen cultural infrastructure and boost various types of popular culture.加强文化基础设施建设,发展各类群众文化。
20 browsers b559db93c279b7e4886705cb45f7ca9c     
  • Three-layer architecture is a model made up of browser, web server and background database server. 这种体系结构是由Browser、Web Server、Database Server组成的浏览器/Web服务器/后台数据库服务器三层模型。 来自互联网
  • Another excellent approach is to abandon the browser entirely and, instead, create a non-browser-based, Internet-enabled application. 另一个非常好的方法是干脆放弃浏览器,取而代之,创建一个不基于浏览器,但却是基于互联网的应用。 来自About Face 3交互设计精髓
21 fungi 6hRx6     
  • Students practice to apply the study of genetics to multicellular plants and fungi.学生们练习把基因学应用到多细胞植物和真菌中。
  • The lawn was covered with fungi.草地上到处都是蘑菇。
22 jigsaw q3Gxa     
  • A jigsaw puzzle can keep me absorbed for hours.一副拼图就能让我沉醉几个小时。
  • Tom likes to work on jigsaw puzzles,too.汤姆也喜欢玩拼图游戏。
TAG标签: species genetic genome zebra