自闭症发病基因被鉴定
文章来源:未知 文章作者:meng 发布时间:2010-03-26 05:37 字体: [ ]  进入论坛
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Two genes2 have been associated with autistic spectrum3 disorders4 (ASD自闭症) in a new study of 661 families. Researchers writing in BioMed Central's newly launched journal Molecular5 Autism found that variations in the genes for two brain proteins, LRRN3 and LRRTM3, were significantly associated with susceptibility(感情,敏感性) to ASD. Anthony Monaco from the Wellcome Trust Centre for Human Genetics, University of Oxford7, UK, worked with an international team of researchers to study four candidate genes in families from the UK, the Netherlands, Italy and Germany. He said, "To our knowledge, this is one of the most comprehensive genetic6 analyses of association between these important genes in brain connections and ASD risk". The proteins encoded by these two genes have been implicated8 in brain development, which is often impaired9 in autistic(孤僻的) individuals. In particular, LRRN3 is thought to play a role in the development and maintenance(维修,保养) of the nervous system, while LRRTM3 is part of a family of proteins thought to organize synaptic(突触的,联合的) connections.

According to Monaco, " A focused candidate gene1 study was carried out using association approaches to identify common variants10 in the UK cohort(支持者,同辈) and in additional European populations. This study covered four brain-enriched leucine(白氨酸,亮氨酸)-rich repeat candidates and taken together, there is converging11(会聚的,趋同的) evidence that common genetic variants in LRRTM3 and LRRN3 confer susceptibility to ASD. Future studies of these genes and their function will provide valuable insights into their role in ASD pathogenesis(发病机理) ".



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1 gene WgKxx     
n.遗传因子,基因
参考例句:
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
2 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句:
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
3 spectrum Trhy6     
n.谱,光谱,频谱;范围,幅度,系列
参考例句:
  • This is a kind of atomic spectrum.这是一种原子光谱。
  • We have known much of the constitution of the solar spectrum.关于太阳光谱的构成,我们已了解不少。
4 disorders 6e49dcafe3638183c823d3aa5b12b010     
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调
参考例句:
  • Reports of anorexia and other eating disorders are on the increase. 据报告,厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
  • The announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》
5 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
6 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
7 Oxford Wmmz0a     
n.牛津(英国城市)
参考例句:
  • At present he has become a Professor of Chemistry at Oxford.他现在已是牛津大学的化学教授了。
  • This is where the road to Oxford joins the road to London.这是去牛津的路与去伦敦的路的汇合处。
8 implicated 8443a53107b44913ed0a3f12cadfa423     
adj.密切关联的;牵涉其中的
参考例句:
  • These groups are very strongly implicated in the violence. 这些组织与这起暴力事件有着极大的关联。 来自《简明英汉词典》
  • Having the stolen goods in his possession implicated him in the robbery. 因藏有赃物使他涉有偷盗的嫌疑。 来自《现代汉英综合大词典》
9 impaired sqtzdr     
adj.受损的;出毛病的;有(身体或智力)缺陷的v.损害,削弱( impair的过去式和过去分词 )
参考例句:
  • Much reading has impaired his vision. 大量读书损害了他的视力。 来自《现代汉英综合大词典》
  • His hearing is somewhat impaired. 他的听觉已受到一定程度的损害。 来自《现代汉英综合大词典》
10 variants 796e0e5ff8114b13b2e23cde9d3c6904     
n.变体( variant的名词复数 );变种;变型;(词等的)变体
参考例句:
  • Those variants will be preserved in the'struggle for existence". 这些变异将在“生存竞争”中被保留下来。 来自辞典例句
  • Like organisms, viruses have variants, generally called strains. 与其他生物一样,病毒也有变种,一般称之为株系。 来自辞典例句
11 converging 23823b9401b4f5d440f61879a369ae50     
adj.收敛[缩]的,会聚的,趋同的v.(线条、运动的物体等)会于一点( converge的现在分词 );(趋于)相似或相同;人或车辆汇集;聚集
参考例句:
  • Plants had gradually evolved along diverging and converging pathways. 植物是沿着趋异和趋同两种途径逐渐演化的。 来自辞典例句
  • This very slowly converging series was known to Leibniz in 1674. 这个收敛很慢的级数是莱布尼茨在1674年得到的。 来自辞典例句
TAG标签: genes autistic ASD
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