阳光是如何使皮肤细胞癌变的?
文章来源:未知 文章作者:meng 发布时间:2010-01-17 03:24 字体: [ ]  进入论坛
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Most skin cancers are highly curable, but require surgery that can be painful and scarring结疤. A new study by Loyola University Health System researchers could lead to alternative treatments that would shrink skin cancer tumors with drugs. The drugs would work by turning on a gene2 that prevents skin cells from becoming cancerous, said senior author Mitchell Denning3, Ph.D.

The study was published Jan. 15, 2010 in the Journal of Biological Chemistry.

More than 1 million people in the United States are diagnosed with skin cancer each year. In the new study, researchers examined a type of skin cancer, called squamous cell carcinoma鳞状细胞癌, that accounts for between 200,000 and 300,000 new cases per year.

Squamous cell carcinoma begins in the upper part of the epidermis上皮,表皮, the top layer of the skin. Most cases develop on areas that receive lots of sun, such as the face, ear, neck, lips and backs of hands. There are various surgical5 treatments, including simple excision切除, curettage刮除术 and electrodessication (scraping with a surgical tool and treating with an electric needle) and cryosurgery冷冻手术,低温外科 (freezing with liquid nitrogen). Removing large skin cancers can require skin grafts植皮手术 and be disfiguring使变丑.

Sunlight can damage a skin cell's DNA8. Normally, a protein called protein kinase C蛋白激酶C (PKC) is activated9 in response to the damage. If the damage is too great to repair, the PKC protein directs the cell to die.

Healthy cells grow and divide in a cell-division cycle. At several checkpoints in this cycle, the cell stops to repair damaged DNA before progressing to the next step in the cycle. The new study found that the PKC gene is responsible for stopping the cell at the checkpoint just before the point when the cell divides. In squamous cell carcinoma, the PKC gene is turned off. The cell proceeds to divide without first stopping to repair its DNA, thus producing daughter tumor1 cells.

Denning said a class of drugs called protein kinase inhibitors potentially could shrink tumors by turning the PKC gene back on. Several such drugs have been approved by the Food and Drug Administration for other cancers. Denning is pursuing grant funding to test such drugs on animal models.



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1 tumor fKxzm     
n.(肿)瘤,肿块(英)tumour
参考例句:
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
2 gene WgKxx     
n.遗传因子,基因
参考例句:
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
3 denning aacb9ba9ad401be7ace6a37a302ef6d0     
vi.穴居(den的现在分词形式)
参考例句:
  • From now on, Dorothy Denning's IDES model was come into being. 在这之后,桃乐茜·顿宁(Dorothy Denning)的IDES(入侵检测专家系统)模型产生了。 来自互联网
4 epidermis AZhzW     
n.表皮
参考例句:
  • The external layer of skin is called the epidermis.皮的外层叫表皮。
  • There is a neoplasm originating in his leg's epidermis.他的腿上有个生长在表皮上的肿瘤。
5 surgical 0hXzV3     
adj.外科的,外科医生的,手术上的
参考例句:
  • He performs the surgical operations at the Red Cross Hospital.他在红十字会医院做外科手术。
  • All surgical instruments must be sterilised before use.所有的外科手术器械在使用之前,必须消毒。
6 excision TnYxU     
n.删掉;除去
参考例句:
  • The excision of the clause has been decided.已经决定删除这个条款。
  • Complete excision is a curative treatment.完全切除是唯一有效的治疗方式。
7 grafts acb4d221b27075a2e8300f0d66dc63f5     
移植( graft的名词复数 ); 行贿; 接穗; 行贿得到的利益
参考例句:
  • He's gone to London for skin grafts on his thighs. 他去伦敦做大腿植皮手术了。
  • Her burns were treated with skin grafts. 她的烧伤是用植皮方法进行治疗的。
8 DNA 4u3z1l     
(缩)deoxyribonucleic acid 脱氧核糖核酸
参考例句:
  • DNA is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
  • Gene mutations are alterations in the DNA code.基因突变是指DNA密码的改变。
9 activated c3905c37f4127686d512a7665206852e     
adj. 激活的 动词activate的过去式和过去分词
参考例句:
  • The canister is filled with activated charcoal.蒸气回收罐中充满了活性炭。
TAG标签: cancer skin cell
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