(PHILADELPHIA) A rapid decline in metabolic¹ activity（新陈代谢活动） on a PET scan（正子扫描） after radiation therapy for non-small cell lung cancer is correlated with（与……相关联） good local tumor² control, according to a study presented by researchers at Thomas Jefferson University Hospital at the 51st ASTRO Annual Meeting. In addition, the researchers also found that the higher the metabolic activity and tumor size on a PET scan before treatment, the more likely a patient is to die from lung cancer.

"PET scanning is an emerging tool of molecular³ imaging in lung cancer, in contrast to CT scans（电脑断层扫描） and MRI scans（核磁共振扫描） which are anatomic（解剖学的） imaging," said Maria Werner-Wasik, associate professor of Radiation Oncology at Jefferson Medical College of Thomas Jefferson University, and the study's lead author. "It has become an important tool in the evaluation⁴ of lung cancer staging and evaluation of treatment response."

Dr. Werner-Wasik and colleagues conducted a retrospective analysis（回顾性分析） of 50 patients with lung cancer who received PET imaging before and after radiation therapy. They analyzed⁵ the prognostic factors（预后因素） for tumor local failure. They measured the metabolic activity using the maximum Standardized⁶ Uptake Value (mSUV). They also measured the tumor size, or the Metabolic Tumor Volume.

The risk of local failure decreased for each unit decline in mSUV by the first post-therapy scan. When compared to the pre-therapy PET scan, the mSUV of the primary tumor declined by 72 percent in the by the first post-therapy scan, 76 percent by the second scan and 77 percent by the third scan. Nineteen patients achieved a metabolic complete response at the median time of 10.6 months. Eight patients suffered local failure. Other factors significantly associated with increased local failure included female gender⁷, stage IV disease and large tumor size.