Individuals who consume a diet high in sodium¹（钠） or artificially sweetened drinks are more likely to experience a decline in kidney function, according to two papers being presented at the American Society of Nephrology's annual meeting in San Diego, California. Julie Lin MD, MPH, FASN and Gary Curhan, MD, ScD, FASN of Brigham and Women's Hospital studied more than 3,000 women participating in the Nurses' Health Study to identify the impact of sodium and sweetened drinks on kidney function.

"There are currently limited data on the role of diet in kidney disease," said Dr. Lin. "While more study is needed, our research suggests that higher sodium and artificially sweetened soda² intake³ are associated with greater rate of decline in kidney function."

The first study, "Associations of Diet with Kidney Function Decline," examined the influence of individual dietary nutrients⁴ on kidney function decline over 11 years in more than 3,000 women participants of the Nurses' Health Study. The authors found that "in women with well-preserved kidney function, higher dietary（饮食的） sodium intake was associated with greater kidney function decline, which is consistent with（一致，符合） experimental animal data that high sodium intake promotes progressive kidney decline（衰微，降低）."

The second study, also conducted by Dr. Lin and Dr. Curhan, "Associations of Sweetened Beverages⁵ with Kidney Function Decline," examined the influence of sugar-sweetened and artificially sweetened beverages（饮料） on kidney function decline in the same group of Nurses' Health Study participants. An analysis of the nationally representative NHANES III participants had previously⁶ reported an association between sugar-sweetened soda and urinary protein（尿蛋白）, but data on kidney function change was not available. This investigation⁷ reported "a significant two-fold increased odds⁸, between two or more servings per day of artificially sweetened soda and faster kidney function decline; no relation between sugar-sweetened beverages and kidney function decline was noted⁹" said Dr. Lin. This association persisted even after the study authors accounted for age, caloric intake（热量摄取）, obesity¹⁰（肥胖）, high blood pressure, diabetes¹¹（糖尿病）, cigarette smoking, physical activity, and cardiovascular disease. The mechanisms¹² for kidney decline in the setting of high intake of artificial sweetenters have not been previously studied and deserve further investigation.