By completing the most comprehensive study of whole cancer genomes to date, an international team of scientists has garnered¹ deeper understanding of cancer, paving the way for more effective treatment, the Wellcome Sanger Institute said on Wednesday.

 

威康桑格学院周三表示，迄今全部癌症基因组的综合研究已完成，来自世界各地的科学家对癌症的研究更加深入，为更有效的治疗铺平了道路。

 

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Project (PCAWG), or the Pan-Cancer Project, is a collaboration² involving more than 1,300 scientists and clinicians from 37 countries. Researchers from the Wellcome Sanger Institute in the UK are part of the team.

 

They analysed more than 2,600 genomes of 38 different tumour³ types, creating a huge resource of primary cancer genomes. This was then the launch-point for 16 working groups studying multiple aspects of cancer's development, causation, progression and classification.

 

In a series of papers published Wednesday in the journal Nature and its affiliated⁴ journals, the Pan-Cancer Project discovers causes of previously⁵ unexplained cancers, pinpoints⁶ cancer-causing events and zeroes in on mechanisms⁷ of development.

 

"The genome of each patient's cancer is unique, but there are a finite set of recurring⁸ patterns, so with large enough studies we can identify all these patterns to optimize⁹ diagnosis¹⁰ and treatment," said Dr. Peter Campbell, member of the Pan-Cancer Project steering¹¹ committee and head of Cancer, Ageing and Somatic Mutation¹² at the Wellcome Sanger Institute.

 

Tumour types can be identified accurately¹³ according to the patterns of genetic¹⁴ changes seen throughout the genome, potentially aiding the diagnosis of a patient's cancer where conventional clinical tests could not identify its type, and knowledge of the exact tumour type could also help tailor treatments, according to the Wellcome Sanger Institute.

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