Memories formed in one part of the brain are replayed and transferred to a different area of the brain during rest, according to a new UCL study in rats. The finding suggests that replay of previous experiences during rest is important for memory consolidation¹, a process whereby the brain stabilises and preserves memories for quick recall in the future. Understanding the physiological² mechanism³ of this is essential for tackling amnesiac⁴ conditions such as Alzheimer's disease, where memory consolidation is affected⁵.

 

Lead researcher, Dr Freyja Ólafsdóttir (UCL Cell & Developmental Biology), said: "We want to understand how a healthy brain stores and accesses memories as this will give us a window into how conditions such as Alzheimer's disease disrupt the process. We know people with Alzheimer's have difficulty recalling the recent past but can often readily remember childhood memories, which seem more resilient. The parts of the brain we studied are some of the first regions affected in Alzheimer's and now we know they are also involved in memory consolidation."

 

The study, published today in Nature Neuroscience and funded by the Wellcome Trust and Royal Society, investigated the role of sleep in memory consolidation by simultaneously⁶ studying two areas of the brain as the rats rested following activity.

 

Six rats each ran for 30 minutes on a six metre long track before resting for 90 minutes. During rest, the team studied the responses of place cells in the hippocampus, where memories are formed, and grid⁷ cells in the entorhinal cortex, where the memories were found to transfer to.

 

The response of the place cells showed that the rats re-ran the track in their minds as they rested but did so at speeds 10-20 times faster than they experienced in reality. The same replay happened almost simultaneously, with a 10 millisecond delay, in grid cells located in a different part of the brain, suggesting that the rats' memories transferred from one part of the brain to another.

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