CRISPR/Cas systems for genome editing have revolutionized biological research over the past three years, and their ability to make targeted changes in DNA¹ sequences in living cells with relative ease and affordability² is now being applied³ to clinical medicine and will have a significant impact on advances in drug and other therapies, agriculture, and food products. The power and promise of this innovation are presented in the Review article "The Bacterial⁴ Origins of the CRISPR Genome-Editing Revolution," published in a special issue of Human Gene⁵ Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Human Gene Therapy website until October 15.2015. Erik Sontheimer, University of Massachusetts Medical School, Worcester, and Rodolphe Barrangou, North Carolina State University, Raleigh, describe the origins of this technology, which were derived⁶ from DNA sequences found in many bacteria known as clustered, regularly interspaced, short palindromic repeats (CRISPR) regions. These are part of bacteria's protective immune system. They have been developed into genome editing tools comprised of a "hardware" component⁷ (an RNA-guided DNA-targeting system that breaks a DNA strand⁸ at a specific site, with the help of the Cas protein), and a "software" component that can be programmed, and re-programmed, to repair or replace a faulty gene.