以色列研究人员研发发现新抗体的新方法
文章来源:未知 文章作者:enread 发布时间:2020-02-12 07:25 字体: [ ]  进入论坛
(单词翻译:双击或拖选)
Israeli researchers have developed a novel method for screening and detecting new efficient antibiotics1, Ben Gurion University (BGU) in southern Israel said Tuesday.
 
以色列本古里安大学周二表示,该校研究人员发现一种筛选发现新型有效抗体的新方法。
 
The method, published in the journal Chemical Science, can help fight antibiotic-resistant bacteria.
 
According to the researchers, the new technology provides an efficient, fast and cost-effective way to identify novel antibiotics that inhibit2 the ribosome, which is the protein-producing machinery3 of all living cells.
 
Inhibition of ribosomal activity in bacterial4 cells, using antibiotics, results in depletion5 of essential proteins and finally in cell death.
 
However, the ribosome is a huge complex containing both RNA molecules6 and several proteins, so identifying drugs that will inhibit its activity is a challenging task.
 
The new method designs antibiotics that target a small RNA region in the ribosome, as focusing on this region allows quick and efficient screening and designing of drugs.
 
The new technology combines empirical screening of small molecular7 fragments that bind8 this RNA region using nuclear magnetic resonance9, with machine learning algorithms that enable the computational design of novel drugs based on the fragments.
 
According to the researchers, their workflow design is applicable not only to antibiotics targeting the ribosome RNA but also for other RNA targets, such as RNA viruses responsible for diseases such as hepatitis or HIV, as well as for other conditions such as cancer.


点击收听单词发音收听单词发音  

1 antibiotics LzgzQT     
n.(用作复数)抗生素;(用作单数)抗生物质的研究;抗生素,抗菌素( antibiotic的名词复数 )
参考例句:
  • the discovery of antibiotics in the 20th century 20世纪抗生素的发现
  • The doctor gave me a prescription for antibiotics. 医生给我开了抗生素。
2 inhibit C7jxT     
vt.阻止,妨碍,抑制
参考例句:
  • Don't let ego and greed inhibit clear thinking and hard work.不要让自我和贪婪妨碍清晰的思维和刻苦的工作。
  • They passed a law to inhibit people from parking in the street.他们通过一项法令以阻止人们在街上停车。
3 machinery CAdxb     
n.(总称)机械,机器;机构
参考例句:
  • Has the machinery been put up ready for the broadcast?广播器材安装完毕了吗?
  • Machinery ought to be well maintained all the time.机器应该随时注意维护。
4 bacterial dy5z8q     
a.细菌的
参考例句:
  • Bacterial reproduction is accelerated in weightless space. 在失重的空间,细菌繁殖加快了。
  • Brain lesions can be caused by bacterial infections. 大脑损伤可能由细菌感染引起。
5 depletion qmcz2     
n.耗尽,枯竭
参考例句:
  • Increased consumption of water has led to rapid depletion of groundwater reserves.用水量的增加导致了地下水贮备迅速枯竭。
  • Farmers should rotate crops every season to prevent depletion of the soil.农夫每季应该要轮耕,以免耗尽土壤。
6 molecules 187c25e49d45ad10b2f266c1fa7a8d49     
分子( molecule的名词复数 )
参考例句:
  • The structure of molecules can be seen under an electron microscope. 分子的结构可在电子显微镜下观察到。
  • Inside the reactor the large molecules are cracked into smaller molecules. 在反应堆里,大分子裂变为小分子。
7 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
8 bind Vt8zi     
vt.捆,包扎;装订;约束;使凝固;vi.变硬
参考例句:
  • I will let the waiter bind up the parcel for you.我让服务生帮你把包裹包起来。
  • He wants a shirt that does not bind him.他要一件不使他觉得过紧的衬衫。
9 resonance hBazC     
n.洪亮;共鸣;共振
参考例句:
  • Playing the piano sets up resonance in those glass ornaments.一弹钢琴那些玻璃饰物就会产生共振。
  • The areas under the two resonance envelopes are unequal.两个共振峰下面的面积是不相等的。
发表评论
请自觉遵守互联网相关的政策法规,严禁发布色情、暴力、反动的言论。
评价:
表情:
验证码:点击我更换图片